Abstract:
:The clinical effect of carbamazepine (CBZ) on neuromuscular transmission is described in two children who presented in coma with diffuse hypotonia and areflexia following CBZ overdose. Repetitive nerve stimulation (RNS) showed a decremental response only at high-frequency stimulation. With supportive care, the patients made an uneventful recovery. Follow-up RNS was normal. This is the first report of a clinically evident neuromuscular transmission defect produced by CBZ. We postulate that CBZ's known effect on decreasing sodium channel depolarization produced a defect in neuromuscular transmission. The report emphasizes the contribution of RNS in the evaluation of coma of uncertain etiology, particularly in cases of possible intoxication, and the potential for CBZ to compromise neuromuscular transmission in normal individuals or in patients with a decreased neuromuscular transmission safety factor.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Zaidat OO,Kaminski HJ,Berenson F,Katirji Bdoi
10.1002/(sici)1097-4598(199909)22:9<1293::aid-mus2subject
Has Abstractpub_date
1999-09-01 00:00:00pages
1293-6issue
9eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199909)22:9<1293::AID-MUS2journal_volume
22pub_type
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