Stem cell route to neuromuscular therapies.

abstract：INTRODUCTION:The aim of this study was to describe the therapeutic effects of immunomodulatory therapy in 3 patients with childhood autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (SRP-ANM). METHODS:Before treatment, data on clinical features, muscle pathology, and thigh MRIs were obta...

journal_title：Muscle & nerve

authors： Zhao Y,Liu X,Zhang W,Yuan Y

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:In this study we evaluated the characteristics of the tibialis anterior muscle after sciatic nerve crush and treatment with low-level laser therapy (LLLT) or the protein from natural latex (P1). METHODS:We studied the following 6 groups of male Wistar rats: control (CG); exposed nerve (EG); injured nerve ...

journal_title：Muscle & nerve

authors： Muniz KL,Dias FJ,Coutinho-Netto J,Calzzani RA,Iyomasa MM,Sousa LG,Santos TT,Teles Vde O,Watanabe IS,Fazan VP,Issa JP

更新日期：2015-11-01 00:00:00

abstract：:Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...

journal_title：Muscle & nerve

authors： Authier FJ,Chariot P,Gherardi RK

更新日期：2005-09-01 00:00:00

abstract：:We applied the singular value decomposition (SVD) method to study single motor unit firing patterns. Two projects were carried out: (1) a computer simulation study to confirm the meanings of two SVD parameters, the eigenvalue corresponding to the positive-slope eigenvector (PEV) and that corresponding to the negative-...

journal_title：Muscle & nerve

authors： Sun TY,Chen JJ,Lin TS

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:The Accurate Test of Limb Isometric Strength (ATLIS) device can reliably measure the strength of 12 muscle groups using a fixed load cell. The purpose of this study was to analyze ATLIS data from healthy adults to calculate an individual's predicted strength scores. METHODS:ATLIS data were collected from ...

journal_title：Muscle & nerve

authors： Andres PL,English R,Mendoza M,Florence J,Malkus E,Schierbecker J,Siener C,Malspeis S,Schoenfeld DA,Munsat TL,Cudkowicz ME

更新日期：2013-02-01 00:00:00

abstract：:Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine recept...

journal_title：Muscle & nerve

authors： De Paepe B,De Bleecker JL

更新日期：2005-05-01 00:00:00

abstract：:The aim of this work was to determine the role of peripheral facial muscle reinnervation in the central reorganization of the blink reflex (BR) after hypoglossal-facial anastomosis (HFA). An electrophysiological study was performed on seven patients who underwent HFA after facial nerve transection during surgery for a...

journal_title：Muscle & nerve

authors： Bernat I,Vitte E,Lamas G,Soudant J,Willer JC,Tankéré F

更新日期：2006-03-01 00:00:00

abstract：:Patients with acute motor axonal neuropathy (AMAN) generally recover well. We reviewed clinical and electrophysiologic recovery in 13 patients for up to 5 years. Twelve patients showed rapid recovery over 12 months, whereas in the remaining one the recovery was slow and incomplete at 5 years. In AMAN, axonal degenerat...

journal_title：Muscle & nerve

authors： Tamura N,Kuwabara S,Misawa S,Kanai K,Nakata M,Sawai S,Mori M,Hattori T

更新日期：2007-06-01 00:00:00

abstract：:Electrophysiological studies were performed on the ventral tail nerve of adult rats following intraperitoneal injection of a crude extract of ciguatoxin from known toxic fish flesh. Ciguatoxin induced significant slowing of both mixed and motor nerve conduction velocities and also significant reductions in both motor ...

journal_title：Muscle & nerve

authors： Cameron J,Flowers AE,Capra MF

更新日期：1993-07-01 00:00:00

abstract：:We report the case of a 27-year-old man treated for bilateral optic neuritis 5 and 3 years before who within a few months developed sensorimotor disorders of the arms and legs characterized by asymmetric distribution and distal prominence. In addition to sensorimotor defects, which were particularly marked in the left...

journal_title：Muscle & nerve

authors： Péréon Y,Jardel J,Guillon B,Guihéneuc P

更新日期：1994-11-01 00:00:00

abstract：:The loss of muscle strength with aging appears to be greater in the lower than upper limbs, but strength and its neural control have never been compared in the same population of individuals in both upper and lower limbs. The aim of this study was to investigate differences between eight young (20-31 years) and eight ...

journal_title：Muscle & nerve

authors： Bazzucchi I,Felici F,Macaluso A,De Vito G

更新日期：2004-11-01 00:00:00

abstract：:Force fluctuations in leg muscles increase after bedrest, perhaps due to modulation of the neural strategy that is specific to a muscle or common to agonist muscles. The purpose of this study was to examine the modulation of muscle activity and force fluctuations during steady contractions with variable involvement of...

journal_title：Muscle & nerve

authors： Yoshitake Y,Kouzaki M,Fukuoka H,Fukunaga T,Shinohara M

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population. METHODS:Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Canc...

journal_title：Muscle & nerve

authors： Abbott D,Johnson NE,Cannon-Albright LA

更新日期：2016-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of spinal cord injury (SCI) and functional electrical stimulation (FES) of paralyzed muscles on type IV collagen content and proteins involving its degradation, which is initiated by matrix metalloproteinase (MMP)-2 and -9 and regulated by their tissue inhibitors (...

journal_title：Muscle & nerve

authors： Koskinen SO,Kjaer M,Mohr T,Sørensen FB,Suuronen T,Takala TE

更新日期：2000-04-01 00:00:00

abstract：INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...

journal_title：Muscle & nerve

authors： Stevenson DA,Allen S,Tidyman WE,Carey JC,Viskochil DH,Stevens A,Hanson H,Sheng X,Thompson BA,Okumura MJ,Reinker K,Johnson B,Rauen KA

更新日期：2012-09-01 00:00:00

abstract：:Masseter (MR) and blink reflexes (BL) were investigated in 51 patients with internuclear ophthalmoplegia (INO) due to multiple sclerosis (28) and lacunar infarction (23). The MR was abnormal in 20 of 23 cases with bilateral INO and in 21 of 28 with unilateral INO. The R1 component of the BL (BL-R1) was abnormal in 7 o...

journal_title：Muscle & nerve

authors： Hopf HC,Thömke F,Gutmann L

更新日期：1991-04-01 00:00:00

abstract：:Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were studied in the diaphragm of early postnatal rats, using radiometric determination of enzyme activities, velocity sedimentation for separation of molecular forms, and electron microscopic cytochemistry to localize enzymes. AChE activity did not change s...

journal_title：Muscle & nerve

authors： Brzin M,Sketelj J,Tennyson VM,Kiauta T,Budininkas-Schoenebeck M

更新日期：1981-11-01 00:00:00

abstract：:Mitochondrial preparations derived from denervated rat skeletal muscle and paired control muscle are characterized with respect to their oxidative and phosphorylative capacities. Our data indicate that there is an impairment within the first 2 energy coupling regions of the respiratory chain and within the ATPase comp...

journal_title：Muscle & nerve

authors： Joffe M,Savage N,Isaacs H

更新日期：1981-11-01 00:00:00

abstract：:An appreciation of the comparative functions of the corticospinal tract is of direct relevance to the understanding of how results from animal models can advance knowledge of the human motor system and its disorders. Two critical functions of the corticospinal tract are discussed: first, the role of descending project...

journal_title：Muscle & nerve

authors： Lemon RN,Griffiths J

更新日期：2005-09-01 00:00:00

abstract：:Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a r...

journal_title：Muscle & nerve

authors： Glover EI,Martin J,Maher A,Thornhill RE,Moran GR,Tarnopolsky MA

更新日期：2010-11-01 00:00:00

abstract：:High-density multichannel electromyography (EMG) recordings add spatial information to the temporal information content of the surface EMG (sEMG) signal. This study explores the potential value of such multichannel information at a single motor unit level, in particular for the improvement of motor unit number estimat...

journal_title：Muscle & nerve

authors： Blok JH,Van Dijk JP,Zwarts MJ,Stegeman DF

更新日期：2005-09-01 00:00:00

abstract：:The physiological and phenotypic properties of motor units in the cat soleus muscle were studied after 4 months of inactivity induced by spinal cord isolation (SI). The soleus of some SI cats were stimulated for 30 min/day during an isometric (SI-I), shortening (SI-S), or lengthening (SI-L) phase of a simulated step c...

journal_title：Muscle & nerve

authors： Zhong H,Roy RR,Hodgson JA,Talmadge RJ,Grossman EJ,Edgerton VR

更新日期：2002-08-01 00:00:00

abstract：:The lack of effective therapy for many of the chronic neuromuscular diseases such as amyotrophic lateral sclerosis, hereditary motor sensory neuropathy (Charcot-Marie-Tooth disease), spinocerebellar degenerations and idiopathic polyneuropathy has led to a search for substances that may stimulate peripheral nerve regen...

journal_title：Muscle & nerve

authors： Bradley WG

更新日期：1990-09-01 00:00:00

abstract：:Frog muscles bathed in solutions equilibrated with 0.5%-2.0% halothane develop large contractures when cooled to 2-4 degrees C. These halothane-cooling contractures (HCC) are dose dependent and reproducible; they are potentiated by lidocaine (5 mM), abolished by procaine (5 mM), and partially inhibited by procainamide...

journal_title：Muscle & nerve

authors： Suarez-Kurtz G,Sudo RT

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Polyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic tests (m+7Ionis ), disability, and health scores were assessed in baseline evaluations of 100 patients entered into an oligonucleotide familial amyloidotic polyneuropathy (FAP) trial. METHODS:We assessed: (1) Proficiency of grading ...

journal_title：Muscle & nerve

authors： Dyck PJ,Kincaid JC,Dyck PJB,Chaudhry V,Goyal NA,Alves C,Salhi H,Wiesman JF,Labeyrie C,Robinson-Papp J,Cardoso M,Laura M,Ruzhansky K,Cortese A,Brannagan TH 3rd,Khoury J,Khella S,Waddington-Cruz M,Ferreira J,Wang AK,

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Factors determining response to intravenous immunoglobulin (IVIg) and plasmapheresis in myasthenia gravis (MG) have not been evaluated systematically. METHODS:This study included patients treated with IVIg (n = 63) or plasmapheresis (n = 42) from two trials evaluating IVIg vs. placebo or plasmapheresis in...

journal_title：Muscle & nerve

authors： Katzberg HD,Barnett C,Bril V

更新日期：2012-05-01 00:00:00

abstract：:Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting musc...

journal_title：Muscle & nerve

authors： Pino LJ,Stashuk DW,Boe SG,Doherty TJ

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to investigate different methods of estimating muscle inactivation, derived from single and multiple voluntary contractions. Ten subjects performed maximal and submaximal leg extensor contractions to determine an interpolation (IT) or central activation ratio (CAR). A superimposed evoke...

journal_title：Muscle & nerve

authors： Behm D,Power K,Drinkwater E

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:Sepsis often causes diaphragm contractile dysfunction. Dihydropyridine receptors (DHPRα1s and DHPRα1c) and ryanodine receptors (RyR1, RyR2, and RyR3) are essential for excitation-contraction coupling in striated muscles. However, their expression in diaphragm during sepsis have not been explored. METHODS:...

journal_title：Muscle & nerve

authors： Jiao GY,Hao LY,Gao CE,Chen L,Sun XF,Yang HL,Li Y,Dai YN

更新日期：2013-11-01 00:00:00

abstract：:Bacterial beta-galactosidase cDNA was injected without lipofectin into 41 sites in dog muscle and expression was seen in 22 of them. The cDNA and lipofectin was injected into 35 similar sites and expression was seen in 21. Expression was seen in a maximum of 2.5% of muscle fibers and 23.21% of nonmuscle cells. A total...

journal_title：Muscle & nerve

authors： Howell JM,Fletcher S,O'Hara A,Johnsen RD,Lloyd F,Kakulas BA

更新日期：1998-02-01 00:00:00