Contribution of the Na(+)-K+ pump to membrane potential in familial periodic paralysis.


:The possibility has been raised that in familial periodic paralysis, the relatively large depolarization of the muscle fiber membrane seen during periods of paralysis might be attributable to a reduction in activity of the electrogenic Na(+)-K+ pump. The theoretical analysis presented here shows that although such hypotheses are qualitatively correct, the quantitative contribution of the electrogenic pump is too small to account entirely for the changes in membrane potential observed between the paralytic and interictal states.


Muscle Nerve


Muscle & nerve


Martin AR,Levinson SR




Has Abstract


1985-06-01 00:00:00












  • Dietary treatment of gluten neuropathy.

    abstract::We studied the effect of a gluten-free diet in patients with idiopathic sensorimotor axonal neuropathy and circulating antigliadin antibodies. Consecutive patients underwent baseline neurophysiological assessment and were offered a gluten-free diet. Those who went on the diet formed the intention-to-treat group and th...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Hadjivassiliou M,Kandler RH,Chattopadhyay AK,Davies-Jones AG,Jarratt JA,Sanders DS,Sharrack B,Grünewald RA

    更新日期:2006-12-01 00:00:00

  • Spontaneous electromyographic activity of the tongue in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:Detection of denervation in muscles in the craniobulbar area is important to assure widespread lower motor neuron involvement in the diagnosis of amyotrophic lateral sclerosis (ALS). The value of spontaneous activity analysis in needle electromyography (EMG) of the tongue has been questioned in the recent ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Tankisi H,Otto M,Pugdahl K,Fuglsang-Frederiksen A

    更新日期:2013-08-01 00:00:00

  • Clinical and molecular aspects of the myotonic dystrophies: a review.

    abstract::Type 1 myotonic dystrophy or DM1 (Steinert's disease), which is the commonest muscular dystrophy in adults, has intrigued physicians for over a century. Unusual features, compared with other dystrophies, include myotonia, anticipation, and involvement of other organs, notably the brain, eyes, smooth muscle, cardiac co...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Machuca-Tzili L,Brook D,Hilton-Jones D

    更新日期:2005-07-01 00:00:00

  • Utility of whole exome sequencing in evaluation of juvenile motor neuron disease.

    abstract:INTRODUCTION:This case report focuses on identifying novel mutations in juvenile motor neuron disease and emphasizes the significance of whole exome sequencing (WES). METHODS:We report a 13-year-old Hispanic boy with rapidly progressive weakness, muscle atrophy, tremor, and tongue fasciculation, along with upper motor...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Agarwal S,Potocki L,Collier TR,Woodbury SL,Adesina AM,Jones J,Lotze TE

    更新日期:2016-04-01 00:00:00

  • Macroglossia in advanced amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Matsuda C,Shimizu T,Nakayama Y,Haraguchi M,Hakuta C,Itagaki Y,Ogura A,Murata K,Taira M,Numayama T,Kinoshita M

    更新日期:2016-09-01 00:00:00

  • Peripheral muscle weakness in RASopathies.

    abstract:INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Stevenson DA,Allen S,Tidyman WE,Carey JC,Viskochil DH,Stevens A,Hanson H,Sheng X,Thompson BA,Okumura MJ,Reinker K,Johnson B,Rauen KA

    更新日期:2012-09-01 00:00:00

  • Assessment of variability in the shape of the motor unit action potential, the "jiggle," at consecutive discharges.

    abstract::A method for quantifying shape variability, the jiggle, or motor unit potentials (MUPs) recorded with conventional EMG electrodes is presented. Amplitude variability at each point of time of the MUP was analyzed. Two new parameters are proposed: the normalized value of the consecutive amplitude differences (CAD), and ...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Stålberg EV,Sonoo M

    更新日期:1994-10-01 00:00:00

  • Lack of cold sensitivity in hyperkalemic periodic paralysis.

    abstract::The nosologic distinction between paramyotonia congenita and hyperkalemic periodic paralysis is somewhat blurred. Muscle membrane inexcitability induced by cooling seems to be characteristic of paramyotonia congenita. The effect of cooling on the maximal compound muscle action potential (CMAP) in patients with paramyo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Subramony SH,Wee AS,Mishra SK

    更新日期:1986-10-01 00:00:00

  • Muscle action potential scans and ultrasound imaging in neurofibromatosis type 2.

    abstract:INTRODUCTION:The neuropathy in patients with neurofibromatosis type 2 (NF2) is difficult to quantify and follow up. In this study we compared 3 methods that may help assess motor axon pathology in NF2 patients. METHODS:Nerve conduction studies in median nerves were supplemented by deriving motor unit number estimates ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Farschtschi S,Gelderblom M,Buschbaum S,Bostock H,Grafe P,Mautner VF

    更新日期:2017-03-01 00:00:00

  • Needle electromyography of the frontalis muscle in patients with amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:We sought to determine which muscles to choose for better assessment of the craniobulbar region in establishing the diagnosis of amyotrophic lateral sclerosis (ALS). METHODS:We studied the frontalis muscle in 83 controls and compared it with the tongue, sternocleidomastoid (SCM), and trapezius muscles in ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Pan H,Jian F,Lin J,Chen N,Zhang Z,Wang Y,Cui L,Kimura J

    更新日期:2016-12-01 00:00:00

  • Factors relating to gender specificity of unloading-induced declines in strength.

    abstract:INTRODUCTION:This investigation aimed to: (1) confirm whether women were more vulnerable to the negative neuromuscular adaptations elicited by muscle unloading and if so, (2) determine which physiological mechanism(s) explain those gender-related differences. METHODS:Healthy young men (20.7 ± 0.3 years) and women (20....

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Deschenes MR,McCoy RW,Mangis KA

    更新日期:2012-08-01 00:00:00

  • Confocal analysis of the dystrophin protein complex in muscular dystrophy.

    abstract::The dystrophin protein complex (DPC), composed of at least 10 proteins that associate with dystrophin, is critical for the maintenance of normal muscle fiber structure and physiology. In this study, we used immunohistochemistry and confocal microscopy to examine the relative abundance and distribution of several of th...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Draviam R,Billington L,Senchak A,Hoffman EP,Watkins SC

    更新日期:2001-02-01 00:00:00

  • Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy.

    abstract:INTRODUCTION:Patients with self-limited statin-related myopathy improve spontaneously when statins are stopped. In contrast, patients with statin-associated autoimmune myopathy have autoantibodies recognizing 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and usually require immunosuppressive therapy to contr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Floyd JS,Brody JA,Tiniakou E,Psaty BM,Mammen A

    更新日期:2016-06-01 00:00:00

  • Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS:We included 55 ALS pat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Schreiber S,Debska-Vielhaber G,Abdulla S,Machts J,Schreiber F,Kropf S,KÖrtvelyessy P,KÖrner S,Kollewe K,Petri S,Dengler R,Kunz WS,Nestor PJ,Vielhaber S

    更新日期:2018-02-01 00:00:00

  • Bone density and alendronate effects in Duchenne muscular dystrophy patients.

    abstract:INTRODUCTION:Patients with DMD have low bone mineral density (BMD) and are at high risk for fractures. We examined changes in BMD and the effects of alendronate in DMD patients treated at our institution in the last decade. METHODS:Retrospective cohort study of 39 DMD patients. RESULTS:Patients had screening dual ene...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Houston C,Mathews K,Shibli-Rahhal A

    更新日期:2014-04-01 00:00:00

  • AAEE case report #18: Ulnar neuropathy in the distal forearm.

    abstract::A 66-year-old professional golf instructor developed pain, numbness, and weakness in an ulnar distribution, but the lesion could not be localized to either elbow or wrist by routine nerve conduction techniques. Stimulation along serial 1-cm increments in the distal forearm disclosed a point of focal conduction block a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Campbell WW

    更新日期:1989-05-01 00:00:00

  • Giant nerves in chronic inflammatory polyradiculoneuropathy.

    abstract:INTRODUCTION:Nerve enlargement (NE) is described in inflammatory and inherited neuropathies. It is commonly multifocal and moderate in the former and homogeneous and generalized in the latter. We describe 4 cases of massive NE in inflammatory neuropathies. METHODS:Patients presented with symptoms of polyneuropathy tha...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Grimm A,Schubert V,Axer H,Ziemann U

    更新日期:2017-02-01 00:00:00

  • Defective oxidative metabolism of myodystrophic skeletal muscle mitochondria.

    abstract::A small-scale procedure for preparing tightly coupled intact skeletal muscle mitochondria from myodystrophic (myd/myd) mice is described. Mitochondrial preparations derived from heart, liver, and skeletal muscle of myd/myd and their littermate (+/?) controls are characterized with respect to their cytochrome content a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Lee CP,Martens ME,Jankulovska L,Neymark MA

    更新日期:1979-09-01 00:00:00

  • Skeletal muscle involvement in tropical spastic paraparesis/HTLV-1-associated myelopathy.

    abstract::The frequency of muscle involvement in TSP/HAM is not known, nor is the precise role that HTLV-1 and the diverse cytokines play in the genesis of HTLV-1-associated diseases. In order to better define the frequency and characteristics of the skeletal muscle involvement in TSP/HAM, we studied 11 affected patients. EMG w...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gabbai AA,Wiley CA,Oliveira AS,Smith R,Schmidt B,Nóbrega JA,Bordin JO,Román GC

    更新日期:1994-08-01 00:00:00

  • M wave changes with temperature in amyotrophic lateral sclerosis and disorders of neuromuscular transmission.

    abstract::Local cooling of the muscle resulted in significant increases in M wave surface areas in patients with ALS, myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and also in controls. The most striking increases were seen in patients with early ALS who had minimal lower motor neuron involvement and/or little defec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Denys EH

    更新日期:1990-07-01 00:00:00

  • Effect of gender and obesity on electrical current thresholds.

    abstract:INTRODUCTION:In this study we investigated the influence of gender and obesity on electrical current thresholds in an attempt to optimize the application of skeletal muscle electrical stimulation (ES) in clinical practice. METHODS:Thirty-two obese and 35 age-matched, non-obese men and women received graded ES to the q...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Maffiuletti NA,Morelli A,Martin A,Duclay J,Billot M,Jubeau M,Agosti F,Sartorio A

    更新日期:2011-08-01 00:00:00

  • Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.

    abstract:INTRODUCTION:Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA. METHODS:We measured th...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Mano T,Katsuno M,Banno H,Suzuki K,Suga N,Hashizume A,Tanaka F,Sobue G

    更新日期:2012-11-01 00:00:00

  • Randomized, double-blind trial of mazindol in Duchenne dystrophy.

    abstract::There is evidence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with Duchenne dystrophy. Muscle strength, contractures, functional ability and pulmonary function we...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Griggs RC,Moxley RT 3rd,Mendell JR,Fenichel GM,Brooke MH,Miller PJ,Mandel S,Florence J,Schierbecker J,Kaiser KK

    更新日期:1990-12-01 00:00:00

  • Variable presentation of nemaline myopathy: novel mutation of alpha actin gene.

    abstract::Nemaline myopathy is a rare disorder of varying severity and genetic etiology. We present two cases, a father and son, with a novel missense mutation in the alpha actin gene. Both have a history of early motor impairment, with the son's course being considerably more severe. This pair illustrates the clinical variabil...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Bouldin AA,Parisi MA,Laing N,Patterson K,Gospe SM Jr

    更新日期:2007-02-01 00:00:00

  • Failure to detect HTLV-I by in situ hybridization in the biopsied muscles of viral carriers with polymyositis.

    abstract::Direct infection of muscle fibers by human T-lymphotropic virus type I (HTLV-I) has recently been reported in a patient with polymyositis infected with both HTLV-I and human immunodeficiency virus (HIV). Coinfections of these viruses are frequently found in the United States. In Kagoshima, Japan, patients with polymyo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Higuchi I,Nerenberg M,Yoshimine K,Yoshida M,Fukunaga H,Tajima K,Osame M

    更新日期:1992-01-01 00:00:00

  • Age-related differences in absolute numbers of skeletal muscle satellite cells.

    abstract::The absolute number of satellite cells (SC) in young and adult rat skeletal muscle was estimated by correlating data from light and electron microscopic quantitation of myofiber nuclei (myonuclei and satellite cell nuclei) with biochemical assays for determining total muscle DNA content. Expressed both as a proportion...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gibson MC,Schultz E

    更新日期:1983-10-01 00:00:00

  • Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury.

    abstract::Muscle of donor origin was formed after implantation of H-2Kb-tsA58 muscle precursor cells (mpc) into irradiated mdx nu/nu mouse muscles. A series of injections of the myotoxin, notexin, which destroys mature muscle fibers but spares muscle precursor cells and other tissues, was made into the mpc-injected muscles, lea...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gross JG,Morgan JE

    更新日期:1999-02-01 00:00:00

  • Ophthalmoplegia, demyelinating neuropathy, leukoencephalopathy, myopathy, and gastrointestinal dysfunction with multiple deletions of mitochondrial DNA: a mitochondrial multisystem disorder in search of a name.

    abstract::This article describes a 37-year-old woman with progressive external ophthalmoplegia, peripheral neuropathy, and chronic intractable diarrhea. Laboratory studies disclosed lactic acidosis, ragged red fibers lacking cytochrome c oxidase, high-normal muscular mitochondrial enzymes, demyelinating neuropathy, leukoencepha...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Uncini A,Servidei S,Silvestri G,Manfredi G,Sabatelli M,Di Muzio A,Ricci E,Mirabella M,Di Mauro S,Tonali P

    更新日期:1994-06-01 00:00:00

  • Basal lamina and superfast myosin expression in regenerating cat jaw muscle.

    abstract::We investigated the possible role of extracellular matrix in specifying the expression of superfast myosin during cat jaw muscle regeneration. Equal proportions of muscle tissue from jaw and limb were minced together after killing cellular elements from one source. We allowed the mince to regenerate in the bed of a fa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Hoh JF,Hughes S

    更新日期:1991-05-01 00:00:00

  • Velocity recovery function of the compound muscle action potential assessed with doublet and triplet stimulation.

    abstract::Normative values of muscle fiber conduction velocity depend on the conditions in which conduction velocity is measured due to the velocity recovery function (VRF) of muscle fibers. In this study the VRF of the compound muscle action potential (CMAP) was assessed following doublet and triplet stimulation in order to in...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kamavuako EN,Hennings K,Farina D

    更新日期:2007-08-01 00:00:00