Abstract:
:Two brothers with the childhood variant of type II glycogenosis (GSD-IIb) treated with nutrition and exercise therapy (NET) from a young age showed an unusually benign course. Muscle biopsy from the older brother, which showed characteristic vacuolar glycogen accumulation at age 2, had reverted to normal by age 16. A muscle biopsy from the younger brother was normal at 5 years. It is uncertain whether this anomalous evolution was spontaneous (nature) or due to the symptomatic therapy (nurture), but NET should be considered in patients with GSD-IIb until enzyme replacement or gene therapy become generally available.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Slonim AE,Bulone L,Minikes J,Hays AP,Shanske S,Tsujino S,DiMauro Sdoi
10.1002/mus.20473subject
Has Abstractpub_date
2006-04-01 00:00:00pages
571-4issue
4eissn
0148-639Xissn
1097-4598journal_volume
33pub_type
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