Inaccurate projection of rat soleus motoneurons: a comparison of nerve repair techniques.

Abstract:

:The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transection injuries to the sciatic nerve, and 2) to determine whether repair of a transected nerve with a silicone tube leads to greater specificity of reinnervation and recovery of muscle function than the standard epineurial suture repair method. Sixty adult female Sprague-Dawley rats were randomly assigned to one of three sciatic nerve injury groups: crush injury, transection with epineurial suture repair, or transection with a silicone tube repair. The degree to which soleus motoneurons were able to find their appropriate target following a sciatic nerve injury was examined using a double labeling dye technique in which the original soleus motor pool was labeled with fast blue and reinnervating motoneurons were labeled with Dil. Soleus motoneurons were able to find their appropriate target following a crush injury. The accuracy of reinnervation following a transection injury and repair, however, was relatively poor. Only 14% of the original soleus motoneurons found the correct target following a transection injury. Repair of a lesioned nerve with a silicone tube and a 5-mm gap as opposed to epineurial sutures did not increase the specificity of reinnervation or the degree of muscle recovery.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Bodine-Fowler SC,Meyer RS,Moskovitz A,Abrams R,Botte MJ

doi

10.1002/(sici)1097-4598(199701)20:1<29::aid-mus4>3

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

29-37

issue

1

eissn

0148-639X

issn

1097-4598

pii

10.1002/(SICI)1097-4598(199701)20:1<29::AID-MUS4>3

journal_volume

20

pub_type

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