Abstract:
:A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decreased F-wave conduction velocities and conduction blocks in motor nerves and decreased or absent sensory action potentials in sensory nerves, with distribution of GD1b in nerve tissues such as dorsal root ganglia and paranodal myelin in the ventral and dorsal roots.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Obi T,Murakami T,Takatsu M,Kusunoki S,Serizawa M,Mizoguchi K,Koike R,Nishimura Ydoi
10.1002/(sici)1097-4598(199910)22:10<1426::aid-mussubject
Has Abstractpub_date
1999-10-01 00:00:00pages
1426-31issue
10eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199910)22:10<1426::AID-MUSjournal_volume
22pub_type
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