Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies.

Abstract:

:A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decreased F-wave conduction velocities and conduction blocks in motor nerves and decreased or absent sensory action potentials in sensory nerves, with distribution of GD1b in nerve tissues such as dorsal root ganglia and paranodal myelin in the ventral and dorsal roots.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Obi T,Murakami T,Takatsu M,Kusunoki S,Serizawa M,Mizoguchi K,Koike R,Nishimura Y

doi

10.1002/(sici)1097-4598(199910)22:10<1426::aid-mus

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

1426-31

issue

10

eissn

0148-639X

issn

1097-4598

pii

10.1002/(SICI)1097-4598(199910)22:10<1426::AID-MUS

journal_volume

22

pub_type

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