Skeletal muscle response to tenotomy.

Abstract:

:Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central core necrosis, Z-line streaming, fibrosis of fibers and Golgi tendon organs, changes in sarcomere number, and alterations in the number of membrane particles. Molecular changes include transient changes in myosin heavy chain composition and expression of neural cell adhesion molecule (NCAM). Functionally, tenotomized muscle produces decreased maximum tetanic and twitch tension. Alterations in normal skeletal muscle structure and function are clinically applicable to the understanding of pathological states that follow tendon rupture and iatrogenic tenotomy.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Jamali AA,Afshar P,Abrams RA,Lieber RL

doi

10.1002/(sici)1097-4598(200006)23:6<851::aid-mus3>

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

851-62

issue

6

eissn

0148-639X

issn

1097-4598

pii

10.1002/(SICI)1097-4598(200006)23:6<851::AID-MUS3>

journal_volume

23

pub_type

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