Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy.

abstract：:Calpains are Ca2+ -dependent cytosolic cysteine proteases that participate in the pathology of Duchenne muscular dystrophy (DMD). Utrophin is a functional homolog of dystrophin that partially compensates for dystrophin deficiency in myofibers of mdx mice. In this study, we investigated the susceptibility of utrophin t...

journal_title：Muscle & nerve

authors： Courdier-Fruh I,Briguet A

更新日期：2006-06-01 00:00:00

abstract：:We have identified a novel missense mutation in the myophosphorylase gene in a Spanish patient with McArdle's disease. The patient was homozygous for a T-to-C transition at codon 115 (L115P) in exon 3, which changed an encoded leucine (CUG) to a proline (CCG). This is the first mutation to be described in exon 3 and i...

journal_title：Muscle & nerve

authors： Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro S

更新日期：1999-08-01 00:00:00

abstract：:In spite of extensive studies it is unclear whether impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), i.e., impaired glucose metabolism (IGM), causes diabetic sensorimotor polyneuropathy (DSPN) or chronic idiopathic axonal polyneuropathy (CIAP); the results and conclusions vary considerably in differ...

journal_title：Muscle & nerve

authors： Dyck PJ,Dyck PJ,Klein CJ,Weigand SD

更新日期：2007-10-01 00:00:00

abstract：:Twenty-four adult albino rats were injected with tetanus toxin into the right gastrocnemius muscle and then subjected to sustained dorsiflexion of the right ankle joint for 2 to 14 days. Histologic examinations of the soleus after this procedure showed myopathic changes, characterized by variations in fiber diameters,...

journal_title：Muscle & nerve

authors： Mizuno Y,Chou SM

更新日期：1990-10-01 00:00:00

abstract：:To evaluate the effect of SMN2 copy number on disease severity in spinal muscular atrophy (SMA), we stratified 45 adult SMA patients based on SMN2 copy number (3 vs. 4 copies). Patients with 3 copies had an earlier age of onset and lower spinal muscular atrophy functional rating scale (SMAFRS) scores and were more lik...

journal_title：Muscle & nerve

authors： Elsheikh B,Prior T,Zhang X,Miller R,Kolb SJ,Moore D,Bradley W,Barohn R,Bryan W,Gelinas D,Iannaccone S,Leshner R,Mendell JR,Mendoza M,Russman B,Smith S,King W,Kissel JT

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Muscle force generation involves recruitment and firing rate modulation of motor units (MUs). The control of MUs in producing multidirectional forces remains unclear. METHODS:We studied MU recruitment and firing properties, recorded from the first dorsal interosseous muscle, for 3 different directions of ...

journal_title：Muscle & nerve

authors： Lei Y,Suresh NL,Rymer WZ,Hu X

更新日期：2018-01-01 00:00:00

abstract：:Immersion of rat hemidiaphragms in Ca2+-free Krebs solution (KS) containing Ca2+ chelator in vitro leads to separation of basal lamina from the plasma membrane, as well as transient contracture and rapid loss of twitch response [calcium paradox (CP) phase 1]. Subsequent immersion in regular KS results in necrosis of m...

journal_title：Muscle & nerve

authors： Soza M,Karpati G,Carpenter S

更新日期：1986-03-01 00:00:00

abstract：:Diseases involving chronic inflammation can lead to prolonged exposure of skeletal muscle to inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), which may contribute to the skeletal muscle weakness seen in these conditions. In this study we examined the effect of a prolonged exposure to TNFalpha on ...

journal_title：Muscle & nerve

authors： van Kann LN,Bakker AJ

更新日期：2007-02-01 00:00:00

abstract：:A new approach to the quantification of fiber type grouping is presented, in which the distribution of histochemical type in a muscle cross section is regarded as a realization of a binary Markov random field (BMRF). Methods for the estimation of the parameters of this model are discussed. The first order BMRF, which ...

journal_title：Muscle & nerve

authors： Venema HW

更新日期：1992-06-01 00:00:00

abstract：:The aim of this investigation was to define the boundaries of compound motor action potential (CMAP) dispersion, amplitude decay, and area decay in a control population and determine their dependence on external variables such as age and interelectrode distance. Measurements were made from median, ulnar, and common pe...

journal_title：Muscle & nerve

authors： Taylor PK

更新日期：1993-11-01 00:00:00

abstract：:The purpose of the present study was to establish the relationship between muscle architecture and H-reflex recordings in quadriceps femoris muscle. H-reflexes were elicited in human quadriceps femoris muscle over a broad area of skin to document the shape and amplitude of the H-potentials. This, in combination with r...

journal_title：Muscle & nerve

authors： Garland SJ,Gerilovsky L,Enoka RM

更新日期：1994-06-01 00:00:00

abstract：:We have developed an algorithm, called multi-motor unit action potential analysis (MMA), to aid quantification in routine needle EMG examination. In only 5-8 min, it was possible to extract, analyze, and validate 20 motor unit action potentials (MUAPs). In the biceps muscle of normal subjects, the MUAP measurements ar...

journal_title：Muscle & nerve

authors： Nandedkar SD,Barkhaus PE,Charles A

更新日期：1995-10-01 00:00:00

abstract：:Variable-frequency stimulation trains (VFTs) that take advantage of the catchlike property of skeletal muscle have been shown to augment the force production of fatigued muscles compared with constant-frequency trains (CFTs). The present study is the first to report the force augmentation produced by VFTs after fatigu...

journal_title：Muscle & nerve

authors： Binder-Macleod SA,Lee SC,Russ DW,Kucharski LJ

更新日期：1998-09-01 00:00:00

abstract：:Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine recept...

journal_title：Muscle & nerve

authors： De Paepe B,De Bleecker JL

更新日期：2005-05-01 00:00:00

abstract：:Normal motor units (MUs) were simulated and their architecture altered to simulate the changes produced by myopathy. The concentric needle electromyographic recordings of motor unit action potentials (MUAPs) from the MUs were then also simulated. These simulated MUAPs showed features that are seen in myopathy: normal ...

journal_title：Muscle & nerve

authors： Nandedkar SD,Sanders DB

更新日期：1989-03-01 00:00:00

abstract：:The lack of effective therapy for many of the chronic neuromuscular diseases such as amyotrophic lateral sclerosis, hereditary motor sensory neuropathy (Charcot-Marie-Tooth disease), spinocerebellar degenerations and idiopathic polyneuropathy has led to a search for substances that may stimulate peripheral nerve regen...

journal_title：Muscle & nerve

authors： Bradley WG

更新日期：1990-09-01 00:00:00

abstract：:The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III ...

journal_title：Muscle & nerve

authors： Salonen V,Lehto M,Kalimo M,Penttinen R,Aro H

更新日期：1985-02-01 00:00:00

abstract：:To identify the underlying physiological mechanisms for the difference in the time to failure for two types of fatiguing contractions, 20 subjects performed force and position tasks with the elbow flexor muscles at a comparable net muscle torque for a similar duration. Prior to terminating each task, blood flow was oc...

journal_title：Muscle & nerve

authors： Rudroff T,Poston B,Shin IS,Bojsen-Møller J,Enoka RM

更新日期：2005-01-01 00:00:00

abstract：:Dystrophic changes of Schwann cells and demyelination occurred in rats with chronic nerve edema induced by feeding a galactose-rich diet for two years. The mechanism for edema is the sorbitol pathway which generates osmotically active polyols from galactose or glucose. The blood-nerve barrier impedes diffusion of macr...

journal_title：Muscle & nerve

authors： Powell HC,Myers RR

更新日期：1983-03-01 00:00:00

abstract：:As caveolin-3 deficiencies may explain persistent hyper-CK-emia, we performed CAV3 gene mutation analysis and immunohistochemistry for caveolin-3 in 31 patients with idiopathic hyper-CK-emia. In 2 of 29 patients who donated blood, variants in the CAV3 gene were detected. Although immunohistochemical analysis strongly ...

journal_title：Muscle & nerve

authors： Reijneveld JC,Ginjaar IB,Frankhuizen WS,Notermans NC

更新日期：2006-11-01 00:00:00

abstract：:Direct infection of muscle fibers by human T-lymphotropic virus type I (HTLV-I) has recently been reported in a patient with polymyositis infected with both HTLV-I and human immunodeficiency virus (HIV). Coinfections of these viruses are frequently found in the United States. In Kagoshima, Japan, patients with polymyo...

journal_title：Muscle & nerve

authors： Higuchi I,Nerenberg M,Yoshimine K,Yoshida M,Fukunaga H,Tajima K,Osame M

更新日期：1992-01-01 00:00:00

abstract：:The influence of the recording site on the motor unit potentials (MUPs) was investigated in the brachial biceps muscle of 8 healthy subjects. The MUPs were recorded with a concentric needle electrode and analyzed with a new decomposition EMG program we call multi-MUP analysis. MUPs had shorter durations and smaller am...

journal_title：Muscle & nerve

authors： Falck B,Stålberg E,Bischoff C

更新日期：1995-12-01 00:00:00

abstract：:Prolonged exposure to hand-transmitted vibration can cause debilitating neural and vascular dysfunction in humans. It is unclear whether the pathophysiology involves simultaneous or sequential injury of arteries and nerves. The mechanism of vibration injury was investigated in a rat tail model, containing arteries and...

journal_title：Muscle & nerve

authors： Curry BD,Bain JL,Yan JG,Zhang LL,Yamaguchi M,Matloub HS,Riley DA

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:Pneumothorax is a potentially serious complication of electromyography (EMG). Data on the frequency of pneumothorax after EMG are lacking. The purpose of this study was to determine the frequency, timing, and risk factors for iatrogenic pneumothorax after EMG. METHODS:Cases of pneumothorax after EMG were ...

journal_title：Muscle & nerve

authors： Kassardjian CD,O'gorman CM,Sorenson EJ

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. METHOD:Female Sprague-Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimu...

journal_title：Muscle & nerve

authors： Kissane RWP,Wright O,Al'Joboori YD,Marczak P,Ichiyama RM,Egginton S

更新日期：2019-03-01 00:00:00

abstract：:A case study of a 50-year-old man who awakened from aortobifemoral bypass graft surgery with painful burning and numbness of the left foot is reported. Angiography showed embolic occlusion of the left popliteal artery proximal to the knee. Nerve conduction studies performed 1 year after occlusion showed loss or severe...

journal_title：Muscle & nerve

authors： Levin KH

更新日期：1989-10-01 00:00:00

abstract：:Electromyographic examination of the deeper external anal sphincter (EAS) muscle is far more uncomfortable than of the subcutaneous muscle, so we tested the need for its examination. We compared the findings in 85 paired examinations of ipsilateral subcutaneous and deeper EAS muscles in 67 patients with a cauda equina...

journal_title：Muscle & nerve

authors： Podnar S

更新日期：2003-09-01 00:00:00

abstract：:To elucidate whether the frontal components of scalp somatosensory evoked potentials (SEPs) depend on the type of peripheral input, we compared scalp SEPs in response to electrical stimuli applied to: (i) the proximal phalanx of the thumb, involving both deep and cutaneous afferents; and (ii) the distal phalanx of the...

journal_title：Muscle & nerve

authors： Restuccia D,Valeriani M,Barba C,Le Pera D,Tonali P,Mauguière F

更新日期：1999-07-01 00:00:00

abstract：:The F-wave was used to estimate the fastest motor nerve conduction velocity (MNCV) along the proximal segment (spinal cord to knee) of the axons of the tibial nerve in 65 control subjects, 8 patients with diabetic polyneuropathy, and 4 patients with Charcot-Marie-Tooth disease. Terminal latencies and MNCV along the di...

journal_title：Muscle & nerve

authors： Panayiotopoulos CP,Scarpalezos S,Nastas PE

更新日期：1978-05-01 00:00:00

abstract：:Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the el...

journal_title：Muscle & nerve

authors： Wee TC,Simon NG

更新日期：2019-11-01 00:00:00