Abstract:
INTRODUCTION:Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats. METHODS:Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. RESULTS:PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. CONCLUSION:PSD induces hormonal alterations that may mediate muscle atrophy.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Dattilo M,Antunes HK,Medeiros A,Mônico-Neto M,Souza Hde S,Lee KS,Tufik S,de Mello MTdoi
10.1002/mus.22322subject
Has Abstractpub_date
2012-03-01 00:00:00pages
431-3issue
3eissn
0148-639Xissn
1097-4598journal_volume
45pub_type
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