Abstract:
INTRODUCTION:Information related to the long-term follow-up of neuropathy in patients with familial amyloid polyneuropathy after liver transplantation is still scarce. METHODS:We describe the neuropathic features of 3 patients with the transthyretin Val30Met mutation. Each patient underwent liver transplantation at an early stage of neuropathy, as indicated by the absence of motor dysfunction and relative preservation of myelinated fibers in sural nerve biopsy specimens. RESULTS:Although the patient with late-onset disease (at age 60 years) presented with the least amount of amyloid deposition, he had neuropathic progression after liver transplantation. An older early-onset (at age 40 years) patient reported a slight exacerbation of both somatic and autonomic neuropathic symptoms 10 years after transplantation. However, the younger early-onset (at age 28 years) patient did not exhibit characteristics suggestive of neuropathy 7 years after transplantation. CONCLUSION:Aging may determine the progression of neuropathy after liver transplantation.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Koike H,Hashimoto R,Tomita M,Kawagashira Y,Iijima M,Nakamura T,Watanabe H,Kamei H,Kiuchi T,Sobue Gdoi
10.1002/mus.23480subject
Has Abstractpub_date
2012-12-01 00:00:00pages
964-70issue
6eissn
0148-639Xissn
1097-4598journal_volume
46pub_type
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