Abstract:
:We studied membrane ultrastructural localization of anionic phospholipids (AP) and sialic acid (SA) calcium binding sites in muscle biopsies from Duchenne muscular dystrophy (DMD) and 3 Becker's muscular dystrophy (BMD) patients using polymyxin B (PXB) and limulus polyphemus (LP) as cytochemical markers. We found that AP calcium binding sites are lacking at muscle cell surface in all DMD muscle tissues, in both intact and degenerating muscle fibers. In BMD, AP have an unusual distribution along plasma membrane. Sialic acid calcium binding sites have the same localization along plasma membrane and basal lamina in DMD, BMD, and control muscles. The absence or alterations of structures involved in calcium binding in DMD and BMD may alter membrane calcium permeability, leading to abnormal Ca2+ influx into cells causing muscle necrosis.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Moggio M,Fagiolari G,Prelle A,Gallanti A,Sciacco M,Scarlato Gdoi
10.1002/mus.880150311subject
Has Abstractpub_date
1992-03-01 00:00:00pages
325-31issue
3eissn
0148-639Xissn
1097-4598journal_volume
15pub_type
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