Efficacy of electrical stimulation of denervated muscle: A multicenter, double-blind, randomized clinical trial.

Abstract:

BACKGROUND:This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries. METHODS:We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical impairment of two muscles, who were randomly treated with real or sham electrical stimulation (ES). Clinical and neurophysiological examinations were performed before treatment, at the end of treatment, and 3 mo posttreatment, by the same physician who was blinded to the ES allocation. RESULTS:All patients improved but there was no significant beneficial effect of ESDM compared with sham treatment. CONCLUSIONS:This study failed to demonstrate the efficacy of ESDM for peripheral nerve injuries. However, given the large number of variables related to ES and the heterogeneity in disease etiologies and clinical manifestations, future studies on homogeneous populations using different stimulation protocols may be useful.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Piccinini G,Cuccagna C,Caliandro P,Coraci D,Germanotta M,Pecchioli C,Padua L

doi

10.1002/mus.26880

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

773-778

issue

6

eissn

0148-639X

issn

1097-4598

journal_volume

61

pub_type

杂志文章,多中心研究,随机对照试验
  • Reduced oxidative muscle metabolism in chronic fatigue syndrome.

    abstract::The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10

    authors: McCully KK,Natelson BH,Iotti S,Sisto S,Leigh JS Jr

    更新日期:1996-05-01 00:00:00

  • Differences in both inositol 1,4,5-trisphosphate mass and inositol 1,4,5-trisphosphate receptors between normal and dystrophic skeletal muscle cell lines.

    abstract::Human normal (RCMH) and Duchenne muscular dystrophy (RCDMD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5-trisphosphate (IP3) mass and IP3 binding to receptors. Basal levels of IP3 were increased two- to threefold in dystrophic...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199807)21:7<902::aid-mus8>

    authors: Liberona JL,Powell JA,Shenoi S,Petherbridge L,Caviedes R,Jaimovich E

    更新日期:1998-07-01 00:00:00

  • Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HAART).

    abstract::Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20338

    authors: Authier FJ,Chariot P,Gherardi RK

    更新日期:2005-09-01 00:00:00

  • Mitochondrial capacity, muscle endurance, and low energy in friedreich ataxia.

    abstract:INTRODUCTION:In this study we noninvasively evaluated skeletal muscle mitochondrial capacity, muscle-specific endurance, and energy/fatigue feelings in persons with Friedreich ataxia (FRDA) and able-bodied controls (AB). METHODS:Forearm mitochondrial capacity was measured in FRDA (n = 16) and AB (n = 10) study partici...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25524

    authors: Bossie HM,Willingham TB,Schoick RAV,O'Connor PJ,McCully KK

    更新日期:2017-10-01 00:00:00

  • Consideration of repetitive nerve stimulation of the median nerve in patients being evaluated for myasthenia gravis.

    abstract::Repetitive nerve stimulation (RNS) of the median nerve is rarely studied in myasthenia gravis (MG). We performed a retrospective analysis of RNS studies performed on 448 patients at our center between 2010 and 2016. Among 95 patients with MG, an abnormal decrement of the compound muscle action potential amplitude was ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26713

    authors: Lee TH,Li Y

    更新日期:2019-12-01 00:00:00

  • Effects of imagery motor training on torque production of ankle plantar flexor muscles.

    abstract::The aim of this study was to investigate in control subjects the effect of imagery training on the torque of plantar-flexor muscles of the ankle. Twenty-nine subjects were allocated to one of three groups that performed either imagery training, low-intensity strength training, or no training (only measurements). The l...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/mus.10406

    authors: Zijdewind I,Toering ST,Bessem B,Van Der Laan O,Diercks RL

    更新日期:2003-08-01 00:00:00

  • Myosin light chain components in single muscle fibers of Duchenne muscular dystrophy.

    abstract::Single muscle fibers were prepared from biopsy specimens of Duchenne muscular dystrophy (DMD), normal, and neuromuscular disease controls. Single muscle cells were classified as type 1, type 2, or intermediate by the skinned fiber method. The intermediate fiber was most abundant in DMD, comprising 29% of fibers examin...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880050511

    authors: Takagi A,Ishiura S,Nonaka I,Sugita H

    更新日期:1982-05-01 00:00:00

  • Continuous motor unit activity confined to the upper extremities.

    abstract::We report a patient with clinical vermiform motor activity, muscle cramps, delayed relaxation of grip, and continuous motor unit discharges who developed mild symmetric symptoms in the upper extremities following a viral infection. Treatment with carbamazepine produced considerable symptomatic improvement. Needle elec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880110310

    authors: Tandan R,Fries TJ

    更新日期:1988-03-01 00:00:00

  • Amyotrophic lateral sclerosis-Evolutionary and other perspectives.

    abstract::In this study some particular and puzzling aspects of amyotrophic lateral sclerosis (ALS) are discussed, with an emphasis on the role of neocortical evolution. Other issues explored include the nature of the clinical deficit in ALS; anatomical and evolutionary aspects of the neocortex, motor cortex, and corpus callosu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21404

    authors: Eisen A

    更新日期:2009-08-01 00:00:00

  • Association between muscle architecture and quadriceps femoris H-reflex.

    abstract::The purpose of the present study was to establish the relationship between muscle architecture and H-reflex recordings in quadriceps femoris muscle. H-reflexes were elicited in human quadriceps femoris muscle over a broad area of skin to document the shape and amplitude of the H-potentials. This, in combination with r...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170604

    authors: Garland SJ,Gerilovsky L,Enoka RM

    更新日期:1994-06-01 00:00:00

  • Defective oxidative metabolism of myodystrophic skeletal muscle mitochondria.

    abstract::A small-scale procedure for preparing tightly coupled intact skeletal muscle mitochondria from myodystrophic (myd/myd) mice is described. Mitochondrial preparations derived from heart, liver, and skeletal muscle of myd/myd and their littermate (+/?) controls are characterized with respect to their cytochrome content a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880020504

    authors: Lee CP,Martens ME,Jankulovska L,Neymark MA

    更新日期:1979-09-01 00:00:00

  • Role of MyoD in denervated, disused, and exercised muscle.

    abstract::The myogenic regulatory factor MyoD plays an important role in embryonic and adult skeletal muscle growth. Even though it is best known as a marker for activated satellite cells, it is also expressed in myonuclei, and its expression can be induced by a variety of different conditions. Several model systems have been u...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.21087

    authors: Legerlotz K,Smith HK

    更新日期:2008-09-01 00:00:00

  • Multifocal motor neuropathy: electrodiagnostic features.

    abstract::Diagnosis of multifocal motor neuropathy (MMN), a syndrome characterized by progressive asymmetric weakness with intact sensation, is important because the disorder often responds to treatment. Multifocal partial motor conduction block (PMCB) has been emphasized as a cardinal feature in the diagnosis of this syndrome,...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170211

    authors: Chaudhry V,Corse AM,Cornblath DR,Kuncl RW,Freimer ML,Griffin JW

    更新日期:1994-02-01 00:00:00

  • Slow-type C-protein in dystrophic chicken fast pectoralis muscle.

    abstract::C-protein isoform expression in hereditary dystrophic chicken skeletal muscle was compared with that in normal chicken muscle during postnatal development by immunocytochemical and immunoblot methods. In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100412

    authors: Obinata T,Shinbo K

    更新日期:1987-05-01 00:00:00

  • Changes in joint angle, muscle-tendon complex length, muscle contractile tissue displacement, and modulation of EMG activity during acute whole-body vibration.

    abstract::It has been suggested that vibration causes small changes in muscle length, but to the best of our knowledge, these have yet to be demonstrated during whole-body vibration (WBV). This was an observational study to determine whether acute WBV would result in muscle lengthening. We hypothesized that acute WBV would incr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21330

    authors: Cochrane DJ,Loram ID,Stannard SR,Rittweger J

    更新日期:2009-09-01 00:00:00

  • Risk of thrombotic events after inpatient intravenous immunoglobulin or plasma exchange for neurologic disease: A case-crossover study.

    abstract:INTRODUCTION:Our aim in this study was to determine whether intravenous immunoglobulin (IVIg) or plasma exchange (PLEx) for treatment of neurologic disease is a trigger for thrombotic events. METHODS:Using administrative data from 2005 to 2014, we identified index admissions for thrombotic events. We performed case-cr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26884

    authors: Jin PH,Shin SC,Dhamoon MS

    更新日期:2020-09-01 00:00:00

  • Biochemical functioning of mitochondria in normal and denervated mammalian skeletal muscle.

    abstract::Mitochondrial preparations derived from denervated rat skeletal muscle and paired control muscle are characterized with respect to their oxidative and phosphorylative capacities. Our data indicate that there is an impairment within the first 2 energy coupling regions of the respiratory chain and within the ATPase comp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880040608

    authors: Joffe M,Savage N,Isaacs H

    更新日期:1981-11-01 00:00:00

  • Nuclear accumulation of expanded PABP2 gene product in oculopharyngeal muscular dystrophy.

    abstract::Autosomal dominant oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disease caused by (GCG) repeat expansions in exon 1 of the poly(A) binding protein 2 gene (PABP2). To elucidate the molecular mechanism underlying the disease, we raised an antiserum against a synthetic peptide fragment predicted from PABP2...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/1097-4598(200010)23:10<1549::aid-mus11>3.0

    authors: Uyama E,Tsukahara T,Goto K,Kurano Y,Ogawa M,Kim YJ,Uchino M,Arahata K

    更新日期:2000-10-01 00:00:00

  • A new mutation in the regulatory domain of the myophosphorylase gene affecting protein dimer contact.

    abstract::We have identified a novel missense mutation in the myophosphorylase gene in a Spanish patient with McArdle's disease. The patient was homozygous for a T-to-C transition at codon 115 (L115P) in exon 3, which changed an encoded leucine (CUG) to a proline (CCG). This is the first mutation to be described in exon 3 and i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199908)22:8<1136::aid-mus2

    authors: Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro S

    更新日期:1999-08-01 00:00:00

  • F- and M-wave conduction velocity in amyotrophic lateral sclerosis.

    abstract::The F-wave was used to estimate motor nerve conduction velocity (MNCV) along the proximal segment of the fastest axons of the deep peroneal nerve (anterior-horn cells to knee) in 13 patients with amyotrophic lateral sclerosis (ALS) and in 21 age- and sex-matched control subjects. Measurements were based on the shortes...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880010607

    authors: Argyropoulos CJ,Panayiotopoulos CP,Scarpalezos S

    更新日期:1978-11-01 00:00:00

  • Recombinant growth hormone treatment of amyotrophic lateral sclerosis.

    abstract::Based on the known trophic effects of growth hormone (GH) on nerve and muscle 75 patients with ALS were treated for up to 18 months with synthetic human growth hormone (Protropin) or a placebo. The course of ALS was assessed serially using a quantitative (TQNE) neuromuscular and manual exam (MRC) and laboratory chemis...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/mus.880160608

    authors: Smith RA,Melmed S,Sherman B,Frane J,Munsat TL,Festoff BW

    更新日期:1993-06-01 00:00:00

  • Paradoxical effect of isoproterenol on hamster hereditary polymyopathy.

    abstract::Isoproterenol (ISO), a potent beta-adrenoreceptor agonist, was found to interfere with the development and progression of hamster hereditary polymyopathy. Cytoprotection involved both skeletal and heart muscles with reduced myofibrillar degeneration, phagocytosis, and an unusual scarring process rarely seen at this st...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880060603

    authors: Jasmin G,Proschek L

    更新日期:1983-07-01 00:00:00

  • A new stain for quantitative measurement of sprouting at neuromuscular junctions.

    abstract::A new combined stain for the simultaneous demonstration of motor nerve terminals and cholinesterase at neuromuscular junctions is described. It employs bromoindoxyl acetate dye-staining for cholinesterase and silver-gold impregnation for nerve terminals. The clarity and reliability of the stain permit quantitative mea...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880010110

    authors: Pestronk A,Drachman DB

    更新日期:1978-01-01 00:00:00

  • Severe childhood muscular dystrophy affecting both sexes and frequent in Tunisia.

    abstract::The authors reported a large study of 93 children presenting a severe form of progressive muscular dystrophy. The first clinical symptoms were noticed between 3 to 12 years. The atrophy affects, predominantly, the girdle and truncal muscles. The hypertrophy of the calves is almost consistent. The progression of the di...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880060702

    authors: Ben Hamida M,Fardeau M,Attia N

    更新日期:1983-09-01 00:00:00

  • Nerve conduction abnormalities in aging mice deficient for myelin-associated glycoprotein.

    abstract::Ultrastructural, biochemical, and electrophysiological analyses were done on 12-14-month-old mice deficient for myelin-associated glycoprotein (MAG) to further characterize the neuropathy that develops as they age. Electron microscopy demonstrated normal myelin compaction and axonal degeneration in a large number of m...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1159

    authors: Weiss MD,Luciano CA,Quarles RH

    更新日期:2001-10-01 00:00:00

  • A freeze-fracture analysis of intramembrane particle densities on dystrophic hamster heart sarcolemma.

    abstract::The intramembrane particle (IMP) profile of control and dystrophic (Bio 14.6) hamster cardiac muscle plasma membrane was assessed in freeze-fracture replicas to determine whether this animal model of muscular dystrophy exhibits the same membrane characteristics found in skeletal muscle from other more thoroughly studi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880070702

    authors: Graham KA,Shivers RR,Atkinson BG

    更新日期:1984-09-01 00:00:00

  • Muscular dystrophy in a litter of golden retriever dogs.

    abstract::Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degenerative muscle disease that were studied until 27 and 40 months of age are described. Initial clinical signs included stilted gait and simultaneous advancement of their pelvic limbs. Further gait restriction and muscle hyper...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880111008

    authors: Kornegay JN,Tuler SM,Miller DM,Levesque DC

    更新日期:1988-10-01 00:00:00

  • PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection.

    abstract:INTRODUCTION:Skeletal muscle oxidative capacity decreases and fatigability increases after spinal cord injury. Transcription factor peroxisome proliferator-activated receptor δ (PPARδ) promotes a more oxidative phenotype. METHODS:We asked whether PPARδ overexpression could ameliorate these deficits in the medial gastr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24723

    authors: Kim JA,Roy RR,Zhong H,Alaynick WA,Embler E,Jang C,Gomez G,Sonoda T,Evans RM,Edgerton VR

    更新日期:2016-02-01 00:00:00

  • Clinical and molecular aspects of the myotonic dystrophies: a review.

    abstract::Type 1 myotonic dystrophy or DM1 (Steinert's disease), which is the commonest muscular dystrophy in adults, has intrigued physicians for over a century. Unusual features, compared with other dystrophies, include myotonia, anticipation, and involvement of other organs, notably the brain, eyes, smooth muscle, cardiac co...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20301

    authors: Machuca-Tzili L,Brook D,Hilton-Jones D

    更新日期:2005-07-01 00:00:00

  • The dropped head syndrome with chronic inflammatory demyelinating polyneuropathy.

    abstract::The dropped head syndrome occurs in a variety of neuromuscular disorders. We present a woman with chronic inflammatory demyelinating polyneuropathy who developed this syndrome, likely reflecting severe demyelination of nerves to cervical paraspinal muscles. ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170717

    authors: Hoffman D,Gutmann L

    更新日期:1994-07-01 00:00:00