Abstract:
INTRODUCTION:Cerebral palsy (CP) is associated with reduced muscle volumes, but previous studies have reported deficits in only a small number of muscles. The extent of volume deficits across lower limb muscles is not known. This study presents an imaging-based assessment of muscle volume and length deficits in 35 lower limb muscles. METHODS:We imaged and segmented 35 muscles in 10 subjects with CP and 8 typically developing (TD) controls using MRI. Muscle volumes were normalized, and Z-scores were computed using TD data. Volume Z-scores and percent deficits in volume, length, and cross-sectional area are reported. RESULTS:Muscle volumes are 20% lower, on average, for subjects with CP. Volume deficits differ significantly between muscles (12%-43%) and display significant heterogeneity across subjects. Distal muscles, especially the soleus, are commonly and severely small. CONCLUSIONS:Heterogeneity across muscles and across subjects reinforces the subject specificity of CP and the need for individualized treatment planning. Muscle Nerve 53: 933-945, 2016.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Handsfield GG,Meyer CH,Abel MF,Blemker SSdoi
10.1002/mus.24972subject
Has Abstractpub_date
2016-06-01 00:00:00pages
933-45issue
6eissn
0148-639Xissn
1097-4598journal_volume
53pub_type
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