Abstract:
:Muscle of donor origin was formed after implantation of H-2Kb-tsA58 muscle precursor cells (mpc) into irradiated mdx nu/nu mouse muscles. A series of injections of the myotoxin, notexin, which destroys mature muscle fibers but spares muscle precursor cells and other tissues, was made into the mpc-injected muscles, leaving time for regeneration to occur between each injection. New muscle fibers of donor origin were formed after up to four notexin treatments, providing evidence that some of the implanted mpc reentered an undifferentiated, quiescent, stem cell-like state and were capable of myogenesis after further injuries to the muscle. A similar model could be used to assay whether preparations of human mpc contain long-lasting precursor cells, prior to their implantation into patients. In control mdx muscles, which had been irradiated, injected with tissue culture medium, and given three notexin injections, regeneration also occurred, indicating that radiation-resistant mpc were present, presumably within the treated muscle.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Gross JG,Morgan JEdoi
10.1002/(sici)1097-4598(199902)22:2<174::aid-mus5>subject
Has Abstractpub_date
1999-02-01 00:00:00pages
174-85issue
2eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199902)22:2<174::AID-MUS5>journal_volume
22pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100607
更新日期:1987-07-01 00:00:00
abstract::The findings in two cases of congenital myasthenia investigated by intercostal muscle biopsy are presented. The first case, a 16-year-old boy, showed reduced miniature endplate potential amplitude and normal 125I-alpha-bungarotoxin binding to postsynaptic acetylcholine receptors. Muscle biopsy and endplate ultrastruct...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090307
更新日期:1986-03-01 00:00:00
abstract::Twenty patients with neurogenic disorders, polymyositis, or muscular dystrophies were assessed clinically and by CT imaging of limb, limb girdle, and trunk muscles, using a standard protocol. On each side of these patients 26 movements were graded by the MRC scale, and 20 muscles were assessed by CT imaging. The clini...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880180706
更新日期:1995-07-01 00:00:00
abstract::We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies. Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatm...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.1109
更新日期:2001-08-01 00:00:00
abstract::During postnatal development of extensor digitorum longus (EDL) muscle, sodium withdrawal contractures were observed during the first 6 days after birth, and not after this time. In regenerating EDL muscles, zero-Na contractures were demonstrated: (1) 7 days after bupivacaine injection, but not 14 or 90 days after thi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199811)21:11<1530::aid-mus
更新日期:1998-11-01 00:00:00
abstract::To study noninvasively multiple descending volleys on alpha motoneurons, we used a 30-50% maximum H-reflex in the wrist flexor muscle conditioned by a subthreshold magnetic stimulus of the contralateral motor cortex as a parameter of motoneuronal excitability in seven neurologically healthy subjects. The time interval...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160406
更新日期:1993-04-01 00:00:00
abstract::There is a paucity of validated tests to quantify hand function impairment due to carpal tunnel syndrome (CTS). The aim of this study was to test the validity and reliability of the Purdue Pegboard Test (PPT) in CTS patients. We compared 190 CTS patients with 122 healthy, age-matched controls. CTS severity was determi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21856
更新日期:2011-02-01 00:00:00
abstract::Loss of skeletal muscle mass (sarcopenia) is a major contributor to disability in old age. We used two-dimensional gel electrophoresis and mass spectrometry to screen for changes in proteins, and cDNA profiling to assess transcriptional regulations in the gastrocnemius muscle of adult (4 months) and aged (30 months) m...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20808
更新日期:2007-08-01 00:00:00
abstract::Platelet-derived microparticle (PDMP) levels were measured using an enzyme-linked immunosorbent assay (ELISA) to elucidate the role of platelet activation in patients with polymyositis or dermatomyositis (PM/DM). PDMP levels in active PM/DM patients (median 13.3 U/ml, interquartile range 9.9-20.7 U/ml, n = 16) and tho...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21311
更新日期:2009-05-01 00:00:00
abstract::Two sisters presented with distal weakness and their muscle biopsy was dystrophic. This distal muscular dystrophy has an autosomal recessive inheritance and its features are somewhat different from the more common autosomal dominant distal muscular dystrophy and include: a) onset in early adult life; b) involvement of...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070610
更新日期:1984-07-01 00:00:00
abstract::Calpains are Ca2+ -dependent cytosolic cysteine proteases that participate in the pathology of Duchenne muscular dystrophy (DMD). Utrophin is a functional homolog of dystrophin that partially compensates for dystrophin deficiency in myofibers of mdx mice. In this study, we investigated the susceptibility of utrophin t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20549
更新日期:2006-06-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to determine factors affecting health-related quality of life (HRQOL) and to propose appropriate treatment targets for patients with myasthenia gravis (MG). METHODS:We evaluated 640 consecutive patients with MG seen at 11 neurological centers. Two-year follow-up data were obtaine...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.24213
更新日期:2014-10-01 00:00:00
abstract::We investigated the possible role of extracellular matrix in specifying the expression of superfast myosin during cat jaw muscle regeneration. Equal proportions of muscle tissue from jaw and limb were minced together after killing cellular elements from one source. We allowed the mince to regenerate in the bed of a fa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140503
更新日期:1991-05-01 00:00:00
abstract:INTRODUCTION:We investigated the possible role of intercostal surgical neurolysis in relieving chronic neuropathic pain refractory to other nonsurgical treatments in patients with postsurgical thoracic pain. METHODS:We retrospectively collected clinical data on patients referred to the Neurosurgery Unit of Policlinic ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26298
更新日期:2018-11-01 00:00:00
abstract::The presence of differences in motor unit activity across contraction types and between hands suggests that the magnitude of fluctuations in motor output is only weakly related when these conditions are compared. Twenty right-handed young (24.1 +/- 5.3 years) and old (72.5 +/- 4.9 years) adults performed three levels ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20326
更新日期:2005-06-01 00:00:00
abstract:INTRODUCTION:This study sought to estimate the global prevalence of transthyretin familial amyloid polyneuropathy (ATTR-FAP). METHODS:Prevalence estimates and information supporting prevalence calculations was extracted from records yielded by reference-database searches (2005-2016), conference proceedings, and nonpee...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26034
更新日期:2018-05-01 00:00:00
abstract::Motor involvement in acute herpes zoster is considered rare, but its incidence is unknown. In a sample of 40 patients with acute herpes zoster of varying severity, an abnormal electromyogram (EMG) (fibrillation, positive waves, high-frequency discharges) was found in 21 (53%), suggesting extension of inflammation to t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199711)20:11<1433::aid-mus
更新日期:1997-11-01 00:00:00
abstract::The intramembrane particle (IMP) profile of control and dystrophic (Bio 14.6) hamster cardiac muscle plasma membrane was assessed in freeze-fracture replicas to determine whether this animal model of muscular dystrophy exhibits the same membrane characteristics found in skeletal muscle from other more thoroughly studi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070702
更新日期:1984-09-01 00:00:00
abstract:INTRODUCTION:Pneumothorax is a potentially serious complication of electromyography (EMG). Data on the frequency of pneumothorax after EMG are lacking. The purpose of this study was to determine the frequency, timing, and risk factors for iatrogenic pneumothorax after EMG. METHODS:Cases of pneumothorax after EMG were ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24883
更新日期:2016-04-01 00:00:00
abstract::Bacterial beta-galactosidase cDNA was injected without lipofectin into 41 sites in dog muscle and expression was seen in 22 of them. The cDNA and lipofectin was injected into 35 similar sites and expression was seen in 21. Expression was seen in a maximum of 2.5% of muscle fibers and 23.21% of nonmuscle cells. A total...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199802)21:2<159::aid-mus2>
更新日期:1998-02-01 00:00:00
abstract::Conduction velocity of A delta fibers of the human peripheral nerves was measured by using pain-related somatosensory evoked potentials following CO2 laser stimulation. It was found to be approximately 9 m/s in the forearm as well as in the lower leg. Because conventional conduction study using electric stimulation re...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880141209
更新日期:1991-12-01 00:00:00
abstract:INTRODUCTION:The neuropathy in patients with neurofibromatosis type 2 (NF2) is difficult to quantify and follow up. In this study we compared 3 methods that may help assess motor axon pathology in NF2 patients. METHODS:Nerve conduction studies in median nerves were supplemented by deriving motor unit number estimates ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25256
更新日期:2017-03-01 00:00:00
abstract::Mitochondrial trifunctional protein (TFP) deficiency is a rare disorder of the fatty acid beta-oxidation cycle with heterogeneous phenotypes and occurs secondary to either alpha- or beta-subunit mutations. We characterized the neuromyopathic phenotype of TFP deficiency through adolescence or adulthood in 11 patients, ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10500
更新日期:2004-01-01 00:00:00
abstract::Although conduction block indicates dysfunction of peripheral nerve, it may occur in patients with clinically typical motor neuron disease. There are no universally accepted criteria to identify conduction block, so diagnosis may be difficult. In some peripheral neuropathies, conduction block persists over long period...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160903
更新日期:1993-09-01 00:00:00
abstract::In acquired polyneuropathies, symptoms and signs are typically distal and symmetrical, more prominent in the lower limbs than the upper limbs. This study was undertaken to measure the extent of the decrease in excitability produced by single impulses and by impulse trains in cutaneous afferents in the median and sural...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200005)23:5<763::aid-mus14
更新日期:2000-05-01 00:00:00
abstract:INTRODUCTION:We performed a retrospective analysis of the clinical, pathological, and electrophysiological features of 21 cases of Asymptomatic vasculitic neuropathy (AsVN). METHODS:Among 270 patients with biopsy-proven vasculitic neuropathy, we identified 21 (7.8%) who had asymptomatic neuropathy. RESULTS:Of the 21 ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24494
更新日期:2015-07-01 00:00:00
abstract::Voluntary and stimulation single-fiber electromyography were performed in the extensor digitorum communis muscle of 15 myasthenic patients. The increase in mean and individual mean consecutive difference as well as the proportion of blocking in the volitional activation were greater than in the stimulation method. The...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199808)21:8<1081::aid-mus1
更新日期:1998-08-01 00:00:00
abstract:INTRODUCTION:Surface electromyography (SEMG) allows objective assessment and guides selection of appropriate treatment in focal hand dystonia (FHD). METHODS:Sixteen-channel SEMG obtained during different phases of a writing task was used to study timing, activation patterns, and spread of muscle contractions in FHD co...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23762
更新日期:2013-09-01 00:00:00
abstract::Morvan's syndrome is a rare disorder characterized by neuromyotonia, hyperhidrosis, and central nervous system dysfunction. We report a patient with features of this syndrome, but who initially presented with breathing difficulties. Concentric needle electromyography showed an abundance of myokymic and neuromyotonic d...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20081
更新日期:2004-08-01 00:00:00
abstract::Neuromuscular recovery after peripheral nerve lesion depends on the regeneration of severed axons that re-establish their functional connection with the denervated muscle. The aim of this study was to determine the effects of electrical stimulation (ES) on the neuromuscular recovery after nerve crush injury in rats. E...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21549
更新日期:2010-05-01 00:00:00