Spinal irradiation does not inhibit distal axonal sprouting.

Abstract:

:In an attempt to determine the relative importance of the nerve cell body and of the axon in initiating and controlling axonal regeneration, nerve cell bodies were irradiated and the ability of the distal axon to sprout was examined. Mice were subjected to either 25 or 50 Gray (Gy) of x-irradiation localized to the lumbar spinal cord. After times varying from 1 day to 6 months after irradiation, a sublethal dose of botulinum toxin (BoTx) was injected into the calf muscles of one leg. The soleus muscle was examined histologically after times varying from 1 week to 6 months after injection, and BoTx-induced ultraterminal axonal sprouting was assessed by the number of motor endplates showing sprouts, the length of the sprouts, and the long term endplate morphology. Apart from some irradiated subgroups having slightly shorter sprout lengths, no significant differences were found between irradiated and nonirradiated groups. The results suggest either that the processes in the nerve cell body responsible for initiating and supporting axonal growth are resistant to large doses of irradiation, or that growth regulatory mechanisms in the distal axon are under local control.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Pamphlett RS

doi

10.1002/mus.880110513

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

493-501

issue

5

eissn

0148-639X

issn

1097-4598

journal_volume

11

pub_type

杂志文章
  • Comparing the force- and excursion- frequency relationships in human skeletal muscle.

    abstract::We examined the influence of varying stimulation frequency on muscle output during isometric and dynamic contractions. Our findings demonstrate that the predictability of the force- and excursion-frequency relationships is extremely strong across stimulation intensities. There were no differences in the frequency whic...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21161

    authors: Gregory CM,Bickel CS,Sharma N,Dixon WE

    更新日期:2008-12-01 00:00:00

  • Efficacy of electrical stimulation of denervated muscle: A multicenter, double-blind, randomized clinical trial.

    abstract:BACKGROUND:This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries. METHODS:We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/mus.26880

    authors: Piccinini G,Cuccagna C,Caliandro P,Coraci D,Germanotta M,Pecchioli C,Padua L

    更新日期:2020-06-01 00:00:00

  • A preparation for studying dystrophic avian muscle and neuromuscular junctions.

    abstract::The extensor of the second digit of the chicken wing (EDII) is a small, fast-twitch muscle susceptible to chicken muscular dystrophy and well suited for correlated studies of the morphology and physiology of identified nerve and muscle fibers. In cross section, the dystrophic EDII shows morphological abnormalities com...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880050103

    authors: Gunther JS,Letinsky MS

    更新日期:1982-01-01 00:00:00

  • The effect of temperature on amount and structure of motor variability during 2-minute maximum voluntary contraction.

    abstract:INTRODUCTION:In this study, we questioned whether local cooling of muscle or heating involving core and muscle temperatures are the main indicators for force variability. METHODS:Ten volunteers performed a 2-min maximum voluntary contraction (MVC) of the knee extensors under control (CON) conditions after passive heat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/mus.23397

    authors: Brazaitis M,Skurvydas A,Pukėnas K,Daniuseviciūtė L,Mickevicienė D,Solianik R

    更新日期:2012-11-01 00:00:00

  • Distal excitability properties of median motor axons.

    abstract::Excitability properties were recorded from 14 volunteers following stimulation of the recurrent motor branch of the median nerve in the palm. Distal stimulation resulted in significantly lower strength-duration time constant and lower threshold during prolonged hyperpolarization than did wrist stimulation in the same ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1205

    authors: Walters RJ,Kiernan MC,Murray NM,Bostock H

    更新日期:2001-12-01 00:00:00

  • Microvascular decompression for hemifacial spasm in patients >65 years of age: an analysis of outcomes and complications.

    abstract:INTRODUCTION:Few data are available to quantify the risks and benefits of microvascular decompression (MVD) in elderly patients with hemifacial spasm. METHODS:Twenty-seven patients >65 years of age and 104 younger patients who underwent MVD for hemifacial spasm (HFS) over a 3-year period were analyzed retrospectively ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23800

    authors: Sekula RF Jr,Frederickson AM,Arnone GD,Quigley MR,Hallett M

    更新日期:2013-11-01 00:00:00

  • Association between pulmonary function and left ventricular volume and function in duchenne muscular dystrophy.

    abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is characterized by absence of the subsarcolemmal protein dystrophin, present in skeletal muscles and cardiomyocytes. We hypothesized that progressive respiratory and left ventricular (LV) insufficiencies in DMD could be parallel and interrelated phenomena. METHODS:We con...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26623

    authors: Khokhar A,Nair A,Midya V,Kumar A,Sinharoy A,Ahmad TA,Abu-Hasan M,Mondal P

    更新日期:2019-09-01 00:00:00

  • Beta-chemokine receptor expression in idiopathic inflammatory myopathies.

    abstract::Beta-chemokines attract and activate T cells and monocytes and have a key role in chronic inflammation. Certain beta-chemokines, such as monocyte chemoattractant protein-1 (MCP-1), have been reported to be upregulated in the idiopathic inflammatory myopathies (IIM). We studied the distribution of beta-chemokine recept...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20294

    authors: De Paepe B,De Bleecker JL

    更新日期:2005-05-01 00:00:00

  • Pathophysiology of spastic paresis. I: Paresis and soft tissue changes.

    abstract::Spastic paresis follows chronic disruption of the central execution of volitional command. Motor function in patients with spastic paresis is subjected over time to three fundamental insults, of which the last two are avoidable: (1) the neural insult itself, which causes paresis, i.e., reduced voluntary motor unit rec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20284

    authors: Gracies JM

    更新日期:2005-05-01 00:00:00

  • Single fiber macro versus concentric trigger macro EMG: a comparison of methods.

    abstract::The values obtained from two different macro EMG methods were compared, and found to be different. Normally, macro electromyography (EMG) is performed with a modified single fiber (SF) needle using the SF potential as a trigger; a new method recommends a modified concentric needle and triggers on the concentric EMG si...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880150211

    authors: Nix WA,Scherer A

    更新日期:1992-02-01 00:00:00

  • Electrical stimulation based on chronaxie reduces atrogin-1 and myoD gene expressions in denervated rat muscle.

    abstract::Denervation induces muscle fiber atrophy and changes in the gene expression rates of skeletal muscle. Electrical stimulation (ES) is a procedure generally used to treat denervated muscles in humans. This study evaluated the effect of ES based on chronaxie and rheobase on the expression of the myoD and atrogin-1 genes ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20668

    authors: Russo TL,Peviani SM,Freria CM,Gigo-Benato D,Geuna S,Salvini TF

    更新日期:2007-01-01 00:00:00

  • Quantitation of central activation failure during maximal voluntary contractions in humans.

    abstract::Muscle fatigue or neuromuscular disease may result in central activation failure during maximal voluntary contractions (MVCs). Superimposition of an electrically stimulated contraction during an MVC has been used to detect central activation failure. To determine the most sensitive means of quantitating central activa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199607)19:7<861::AID-MUS8>

    authors: Kent-Braun JA,Le Blanc R

    更新日期:1996-07-01 00:00:00

  • Magnetic resonance imaging of muscle injury and atrophy in glycolytic myopathies.

    abstract::Exertional muscle pain, contractures, recurrent rhabdomyolysis, and pigmenturia are common in certain muscle glycolytic disorders. However, the frequency, distribution, and long-term significance of these findings are poorly understood. First we performed magnetic resonance imaging (MRI) of the extremities as a screen...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880121011

    authors: Fleckenstein JL,Peshock RM,Lewis SF,Haller RG

    更新日期:1989-10-01 00:00:00

  • Neuromyotonia, peripheral neuropathy and myasthenia gravis.

    abstract::A patient with neuromyotonia, peripheral neuropathy and myasthenia gravis (MG) is described. Neurophysiological studies, at rest, showed continuous muscle discharges of motor unit action potentials (MUAPs) in duplets and triplets. Motor (MNCV) and sensory (SNCV) nerve conduction studies revealed mild axonal and demyel...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199604)19:4<505::AID-MUS10

    authors: Martinelli P,Patuelli A,Minardi C,Cau A,Riviera AM,Dal Pozzo F

    更新日期:1996-04-01 00:00:00

  • Ultrasound imaging of the quadriceps muscle in elderly athletes and untrained men.

    abstract::Ultrasound (US) technique was applied to measure the thickness, cross-sectional area (CSA), and internal structure of the quadriceps muscle in 70- to 80-year-old endurance and power athletes and untrained men. Isometric knee extension strength was higher in the power athletes than in the other groups. The mean values ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880140607

    authors: Sipilä S,Suominen H

    更新日期:1991-06-01 00:00:00

  • Motor function-muscle strength relationship in spinal muscular atrophy.

    abstract::The relationship between motor function and muscle strength in patients with spinal muscular atrophy (SMA) is still controversial. In 120 genetically proven SMA patients, aged 5 years or older, we measured muscle strength in the arms and legs by a hand-held dynamometer, forced vital capacity by a spirometer, and the t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20018

    authors: Merlini L,Bertini E,Minetti C,Mongini T,Morandi L,Angelini C,Vita G

    更新日期:2004-04-01 00:00:00

  • Proteasome inhibitors for malignancy-related Lambert-Eaton myasthenic syndrome.

    abstract::Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by autoantibodies against presynaptic voltage-gated calcium channels that impair neuromuscular transmission. Malignancies, especially small cell lung cancer (SCLC), have been associated with LEMS and account for approximately 60% of cases...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24122

    authors: Wang C,Chen S,Feng B,Guan Y

    更新日期:2014-03-01 00:00:00

  • The conventional tuning fork as a quantitative tool for vibration threshold.

    abstract:INTRODUCTION:This study was undertaken to describe a method for quantifying vibration when using a conventional tuning fork (CTF) in comparison to a Rydel-Seiffer tuning fork (RSTF) and to provide reference values. METHODS:Vibration thresholds at index finger and big toe were obtained in 281 participants. Spearman's c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25680

    authors: Alanazy MH,Alfurayh NA,Almweisheer SN,Aljafen BN,Muayqil T

    更新日期:2018-01-01 00:00:00

  • Neurofibromatous neuropathy.

    abstract::Three cases of chronic distal sensorimotor neuropathy are described in patients with neurofibromatosis. One had type 2 or central neurofibromatosis with a chromosome 22 deletion; the precise form of the disease was not established in the other two. A striking clinical feature was a diffuse nodular enlargement of the p...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880130202

    authors: Thomas PK,King RH,Chiang TR,Scaravilli F,Sharma AK,Downie AW

    更新日期:1990-02-01 00:00:00

  • Comparison of electric and magnetic coil stimulation in the supraclavicular region.

    abstract::We compared the compound motor action potentials (CMAPs) evoked in the biceps, triceps, and abductor digiti minimi (ADM) muscles by conventional electrical stimulation at Erb's point (EP), and by magnetic coil stimulation of the supraclavicular region in 11 normal subjects. We found that magnetic coil stimulation was ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880150509

    authors: Cros D,Gominak S,Shahani B,Fang J,Day B

    更新日期:1992-05-01 00:00:00

  • Urinary retention and sympathetic sphincter obstruction in axonal Guillain-Barré syndrome.

    abstract::A 62-year-old woman with axonal Guillain-Barré syndrome developed weakness and urinary retention simultaneously. The retention failed to recover for 10 months even after she regained the ability to walk. The patient exhibited no postural hypotension. Videourodynamics showed that the retention was caused not by the bla...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20639

    authors: Sakakibara R,Uchiyama T,Tamura N,Kuwabara S,Asahina M,Hattori T

    更新日期:2007-01-01 00:00:00

  • Surgery for peripheral nerve and brachial plexus injuries or other nerve lesions.

    abstract::The selection of patients who will benefit from peripheral nerve surgery continues to evolve. The evaluation of patients with peripheral nerve problems, and the indications and timing of surgery are reviewed. This includes patients with transections, lesions in continuity, entrapments, tumors, injection injuries, and ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(200005)23:5<680::aid-mus4>

    authors: Spinner RJ,Kline DG

    更新日期:2000-05-01 00:00:00

  • Helix-loop-helix transcription factors in electrically active and inactive skeletal muscles.

    abstract::The muscle-specific helix-loop-helix (HLH) transcription factors myoD, myogenin, MRF4, and myf-5 are called the muscle regulatory factor family (MRF). Levels of MRFs are strongly regulated by muscle electrical activity and are thought to control downstream genes that are important for muscle phenotype such as the acet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/1097-4598(200009)23:9<1374::aid-mus8>3.0.c

    authors: Carlsen H,Gundersen K

    更新日期:2000-09-01 00:00:00

  • Isolated necrotizing myopathy associated with ANTI-PL12 antibody.

    abstract:INTRODUCTION:Immune-mediated myopathies are a heterogeneous group of chronic autoimmune disorders. Autoantibodies associated with this disease complex are classified into myositis-associated and myositis-specific. Anti-tRNA synthetase antibodies are the most well known of the myositis-specific antibodies. Previous repo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23383

    authors: Mehndiratta P,Mehta S,Manjila SV,Kammer GM,Cohen ML,Preston DC

    更新日期:2012-08-01 00:00:00

  • Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.

    abstract:INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24929

    authors: Elsheikh B,Arnold WD,Gharibshahi S,Reynolds J,Freimer M,Kissel JT

    更新日期:2016-01-01 00:00:00

  • Clinical electrophysiology of infantile botulism.

    abstract::Infantile botulism is a recently recognized cause of acute hypotonic paresis and respiratory failure in young infants. Electrophysiological testing has proven useful in early diagnosis in suspected cases by demonstrating abnormal neuromuscular transmission as is known to occur in botulism. Twenty-five infants with bac...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880060609

    authors: Cornblath DR,Sladky JT,Sumner AJ

    更新日期:1983-07-01 00:00:00

  • Stroke-related effects on maximal dynamic hip flexor fatigability and functional implications.

    abstract:INTRODUCTION:Stroke-related changes in maximal dynamic hip flexor muscle fatigability may be more relevant functionally than isometric hip flexor fatigability. METHODS:Ten chronic stroke survivors performed 5 sets of 30 hip flexion maximal dynamic voluntary contractions (MDVC). A maximal isometric voluntary contractio...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24520

    authors: Kuhnen HR,Rybar MM,Onushko T,Doyel RE,Hunter SK,Schmit BD,Hyngstrom AS

    更新日期:2015-03-01 00:00:00

  • Abductor hallucis false motor points: electrophysiologic mapping and cadaveric dissection.

    abstract::False motor points (FMPs) can occur in intrinsic foot or hand muscles, causing spuriously prolonged distal motor latencies by misrepresenting the compound muscle action potential (CMAP) onset. We investigated the motor point (MP) and possible FMPs in abductor hallucis (AH) by three methods: (1) electrophysiologic mapp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199609)19:9<1138::AID-MUS9

    authors: Del Toro DR,Park TA

    更新日期:1996-09-01 00:00:00

  • Cognitive impairment in neuromuscular disorders.

    abstract::Several studies have suggested the presence of central nervous system involvement manifesting as cognitive impairment in diseases traditionally confined to the peripheral nervous system. The aim of this review is to highlight the character of clinical, genetic, neurofunctional, cognitive, and psychiatric deficits in n...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20535

    authors: D'Angelo MG,Bresolin N

    更新日期:2006-07-01 00:00:00

  • Chronic idiopathic axonal polyneuropathy: Electrophysiological progression and human leukocyte antigen associations.

    abstract:BACKGROUND:We aimed to describe the electrophysiological progression rate of chronic idiopathic axonal polyneuropathy (CIAP) and look into the potential role of human leukocyte antigen (HLA) genetic susceptibility in its development. METHODS:We recruited 57 patients with CIAP (mean age at diagnosis 67, mean follow-up ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.27164

    authors: Zis P,Sarrigiannis PG,Artemiadis A,Skarlatou V,Hadjivassiliou M

    更新日期:2021-01-13 00:00:00