Acute morphologic changes in orbicularis oculi muscle after doxorubicin injection into the eyelid.

Abstract:

:This study attempts to gain a better understanding of the primary cause of doxorubicin myotoxicity to aid in the development of a protocol to increase its effectiveness in treating muscle spasm diseases. The time course of acute injury to the orbicularis oculi muscle after injection of doxorubicin into the eyelids of rabbits was examined. The effects of doxorubicin injection were immediate and dramatic. Within 5 minutes, the muscle cells in the eyelids showed signs of myofibrillar dissolution. This process continued for the first 24 hours, with a marked decrease in the total number of myofibers by 1 hour after drug treatment. By 4 days after doxorubicin injection, most of the treated muscle had a more normal morphology, although some ongoing myofibrillar dissolution was present. There was evidence for a limited amount of muscle regeneration. Three levels of injury were seen: a severe, irreversible injury in the majority of the myofibers; a mild, reversible injury in a subset of the fibers; and a group of myofibers apparently uninjured as a result of doxorubicin treatment. Doxorubicin toxicity in skeletal muscle is of rapid onset. Understanding the primary cause and acute changes in doxorubicin myotoxicity may accelerate the development of improved protocols to increase the effectiveness of doxorubicin in treating muscle spasm diseases.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

McLoon LK,Luo XX,Wirtschafter J

doi

10.1002/mus.880160708

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

737-43

issue

7

eissn

0148-639X

issn

1097-4598

journal_volume

16

pub_type

杂志文章
  • Twice-weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy.

    abstract:INTRODUCTION:Glucocorticosteroids (GC) are effective in slowing weakness in boys with Duchenne muscular dystrophy (DMD). METHODS:This is a multisite, 1-year, open-label trial of twice-weekly prednisolone (5 mg/kg/dose) in infants/young boys (0.4-2.4 years) with DMD. We compared changes in Bayley III Scales of Infant D...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26441

    authors: Connolly AM,Zaidman CM,Golumbek PT,Cradock MM,Flanigan KM,Kuntz NL,Finkel RS,McDonald CM,Iannaccone ST,Anand P,Siener CA,Florence JM,Lowes LP,Alfano LN,Johnson LB,Nicorici A,Nelson LL,Mendell JR,MDA DMD Clinical Resea

    更新日期:2019-06-01 00:00:00

  • Short-term aerobic training response in chronic myopathies.

    abstract::We have previously demonstrated that patients with mitochondrial myopathies can benefit from short-term aerobic exercise training. In this study, we compared the responses to short-term aerobic training of patients with mitochondrial myopathies, patients with nonmetabolic myopathies, and sedentary normal subjects. Tra...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-4598(199909)22:9<1239::aid-mus1

    authors: Taivassalo T,De Stefano N,Chen J,Karpati G,Arnold DL,Argov Z

    更新日期:1999-09-01 00:00:00

  • Somatosensory evoked potentials of the medial and lateral plantar and calcaneal nerves.

    abstract::The ideal electrodiagnostic procedure to assess possible plantar neuropathies continues to elude investigators. Motor studies are rarely abnormal, pure sensory studies may be difficult to obtain, needle electromyography can demonstrate membrane instability in normal feet. Mixed nerve plantar studies may be more diagno...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880140710

    authors: Dumitru D,Kalantri A,Dierschke B

    更新日期:1991-07-01 00:00:00

  • Skeletal muscle cell MHC I expression: implications for statin-induced myopathy.

    abstract::Statins can induce necrotizing or inflammatory myopathies in some patients. Increased major histocompatibility complex class I (MHC I) expression has been shown in muscle biopsies of statin-induced myopathy. Therefore, we investigated the effect of statins on the expression of MHC I in muscle cells. Using flow cytomet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21479

    authors: Singh P,Kohr D,Kaps M,Blaes F

    更新日期:2010-02-01 00:00:00

  • Growth and denervation response of skeletal muscle fibers of newborn rats.

    abstract::The cross-sectional area of the fibers of hindlimb muscles of rats increased 10-40 times during the first 6 weeks after birth. Denervation at birth stopped the growth of the muscle fibers. The number of satellite cells decreased, and eventually all fibers vanished. Reinnervation, if any, was poor. Partial denervation ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880130509

    authors: Schmalbruch H

    更新日期:1990-05-01 00:00:00

  • Classification of peripheral neuropathy: the long and the short of it.

    abstract::Insights into how the nervous system functions have often sprung from knowledge of the localization of nervous system diseases. Indeed, the recent rebirth of behavioral neurology has been sparked by new insights into the topography of higher cortical functions. Yet, the localization of disease affecting the peripheral...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.880090806

    authors: Sabin TD

    更新日期:1986-10-01 00:00:00

  • Phospholipid methylation in skeletal muscle membranes.

    abstract::Phospholipid methylation is thought to modulate such vital cellular processes as calcium transport, receptor function, and membrane microviscosity. As these processes are fundamental to the function of muscle cells and are thought to be altered in disease states, we have characterized several features of phospholipid ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880080513

    authors: Kuncl RW,Drachman DB,Kishimoto Y

    更新日期:1985-06-01 00:00:00

  • Lower limb muscle strength impairment in late-onset and adult myotonic dystrophy type 1 phenotypes.

    abstract:INTRODUCTION:Lower limb strength has never been characterized separately for late-onset and adult myotonic dystrophy type 1 (DM1) phenotypes. METHODS:The purpose of this study was to: (1) describe and compare lower limb strength between the 2 DM1 phenotypes; and (2) compare the impairment profiles obtained from 2 asse...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25451

    authors: Petitclerc É,Hébert LJ,Mathieu J,Desrosiers J,Gagnon C

    更新日期:2017-07-01 00:00:00

  • Comparison of distal sympathetic with vagal function in diabetic neuropathy.

    abstract::We measured distal sympathetic and vagal function in 73 consecutive patients with diabetic neuropathy seen at the Mayo Autonomic Reflex Laboratory. Postganglionic sympathetic failure measured proximally within the foot occurred as commonly as vagal failure (58% and 55%, respectively) and occurred much more frequently ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090703

    authors: Low PA,Zimmerman BR,Dyck PJ

    更新日期:1986-09-01 00:00:00

  • Ulnar neuropathy and dystonic flexion of the fourth and fifth digits: clinical correlation in musicians.

    abstract::Peripheral nerve lesions are sometimes associated with focal dystonia. We diagnosed ulnar neuropathy in 28 of 73 (40%) cases of occupational cramp in musicians. Focal slowing of ulnar conduction across the elbow was identified in 15 of 19 (79%) patients using the near nerve technique and in 5 of 17 (29%) patients usin...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880190403

    authors: Charness ME,Ross MH,Shefner JM

    更新日期:1996-04-01 00:00:00

  • Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy.

    abstract:INTRODUCTION:Livedoid vasculopathy is a rare dermatological condition characterized by painful ulceration, atrophic scarring, and persistent livedo reticularis. The pathogenesis is unclear. METHODS:We report a patient with biopsy-proven livedoid vasculopathy who developed a progressive sensory ganglionopathy with prof...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24452

    authors: Alix JJ,Hadjivassiliou M,Ali R,Slater D,Messenger AG,Rao DG

    更新日期:2015-02-01 00:00:00

  • Statistical motor unit number estimation: reproducibility and sources of error in patients with amyotrophic lateral sclerosis.

    abstract::The reliability of motor unit number estimation (MUNE) for assessment of the long-term course of ALS is dependent on the reproducibility of the technique. We report our results with the statistical method of MUNE on the ulnar nerve/hypothenar muscle in 16 ALS patients who were studied on 52 occasions. On each occasion...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-4598(200002)23:2<193::aid-mus8>

    authors: Olney RK,Yuen EC,Engstrom JW

    更新日期:2000-02-01 00:00:00

  • Pain location and intensity impacts function in persons with myotonic dystrophy type 1 and facioscapulohumeral dystrophy with chronic pain.

    abstract:INTRODUCTION:We examined the effects of pain site and intensity on function in patients with myotonic dystrophy type 1 (DM1) and facioscapulohumeral muscular dystrophy (FSHD) and chronic pain. METHODS:Questionnaires assessing pain sites, pain extent (number of sites), pain intensity, and pain interference were complet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24079

    authors: Miró J,Gertz KJ,Carter GT,Jensen MP

    更新日期:2014-06-01 00:00:00

  • Anconeus motor unit number estimates using decomposition-based quantitative electromyography.

    abstract:INTRODUCTION:Motor unit number estimates (MUNEs) provide important information in health, aging, and disease, and can be determined using decomposition-enhanced spike-triggered averaging (DE-STA). Discrimination of surface-detected motor unit potentials (S-MUPs) has been limited to contractile forces of ∽30% maximum vo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24092

    authors: Stevens DE,Harwood B,Power GA,Doherty TJ,Rice CL

    更新日期:2014-07-01 00:00:00

  • Contrasting echogenicity in flexor digitorum profundus-flexor carpi ulnaris: a diagnostic ultrasound pattern in sporadic inclusion body myositis.

    abstract:INTRODUCTION:In this study we aimed to clarify whether muscle ultrasound (US) of the forearm can be used to differentiate between patients with sporadic inclusion body myositis (s-IBM) and those with s-IBM-mimicking diseases. METHODS:We compared the echo intensity (EI) of the flexor digitorum profundus (FDP) muscle an...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24056

    authors: Noto Y,Shiga K,Tsuji Y,Kondo M,Tokuda T,Mizuno T,Nakagawa M

    更新日期:2014-05-01 00:00:00

  • Reduced DHPRα1S and RyR1 expression levels are associated with diaphragm contractile dysfunction during sepsis.

    abstract:INTRODUCTION:Sepsis often causes diaphragm contractile dysfunction. Dihydropyridine receptors (DHPRα1s and DHPRα1c) and ryanodine receptors (RyR1, RyR2, and RyR3) are essential for excitation-contraction coupling in striated muscles. However, their expression in diaphragm during sepsis have not been explored. METHODS:...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23805

    authors: Jiao GY,Hao LY,Gao CE,Chen L,Sun XF,Yang HL,Li Y,Dai YN

    更新日期:2013-11-01 00:00:00

  • Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.

    abstract:INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24929

    authors: Elsheikh B,Arnold WD,Gharibshahi S,Reynolds J,Freimer M,Kissel JT

    更新日期:2016-01-01 00:00:00

  • Quantitation of central activation failure during maximal voluntary contractions in humans.

    abstract::Muscle fatigue or neuromuscular disease may result in central activation failure during maximal voluntary contractions (MVCs). Superimposition of an electrically stimulated contraction during an MVC has been used to detect central activation failure. To determine the most sensitive means of quantitating central activa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199607)19:7<861::AID-MUS8>

    authors: Kent-Braun JA,Le Blanc R

    更新日期:1996-07-01 00:00:00

  • Glycerophospholipid profile alterations are associated with murine muscle-wasting phenotype.

    abstract:INTRODUCTION:Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear. METHODS:We carried out comprehensive phospholipid analyses using liqu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26993

    authors: Senoo N,Miyoshi N,Kobayashi E,Morita A,Tanihata J,Takeda S,Miura S

    更新日期:2020-09-01 00:00:00

  • Immunohistochemical characterization of human masseter muscle spindles.

    abstract::An enzyme- and immunohistochemical study has been performed on human masseter muscle spindles. Antibodies selective for different myosin heavy chain (MHC) isoforms and M-band proteins (M-protein, myomesin, and MM-CK) were used. The expression of these proteins was determined in the different intrafusal fiber types. Nu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170105

    authors: Eriksson PO,Butler-Browne GS,Thornell LE

    更新日期:1994-01-01 00:00:00

  • What does chronic electrical stimulation teach us about muscle plasticity?

    abstract::The model of chronic low-frequency stimulation for the study of muscle plasticity was developed over 30 years ago. This protocol leads to a transformation of fast, fatigable muscles toward slower, fatigue-resistant ones. It involves qualitative and quantitative changes of all elements of the muscle fiber studied so fa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(199906)22:6<666::aid-mus3>

    authors: Pette D,Vrbová G

    更新日期:1999-06-01 00:00:00

  • Sural nerve biopsy studies in Leigh's subacute necrotizing encephalomyelopathy.

    abstract::Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myel...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090210

    authors: Goebel HH,Bardosi A,Friede RL,Kohlschütter A,Albani M,Siemes H

    更新日期:1986-02-01 00:00:00

  • Yields of muscle from myogenic cells implanted into young and old mdx hosts.

    abstract::Implantation of normal muscle precursor cells (mpc) for treatment for inherited myopathies such as Duchenne muscular dystrophy is in clear need of improvement to become practicable, but few variables have been studied comparatively. Here, we report the first quantitative estimate of the effectiveness of implanting mpc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199602)19:2<132::AID-MUS2>

    authors: Morgan JE,Fletcher RM,Partridge TA

    更新日期:1996-02-01 00:00:00

  • Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes.

    abstract::Skeletal muscle cells are hypertrophied by mechanical stresses, but the underlying molecular mechanisms are not fully understood. Two signaling pathways, phosphatidylinositol 3-kinase (PI3K)/Akt to target of rapamycin (TOR) and extracellular signal-regulated kinase kinase (MEK) to extracellular signal-regulated kinase...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21473

    authors: Sasai N,Agata N,Inoue-Miyazu M,Kawakami K,Kobayashi K,Sokabe M,Hayakawa K

    更新日期:2010-01-01 00:00:00

  • Isometric contractions of normal and spastic human skeletal muscle.

    abstract::Isometric contractile properties of human elbow flexor muscles were examined in 27 normal subjects (7 females and 20 males). Contractions of elbow flexors were elicited by application of electrical pulses to the biceps motor points. The tension development was recorded at the wrist with the elbow angle fixed at 90 deg...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880040307

    authors: Ismail HM,Ranatunga KW

    更新日期:1981-05-01 00:00:00

  • Conduction block in neuralgic amyotrophy.

    abstract::We describe two cases of neuralgic amyotrophy with electrophysiological evidence of conduction block across the lower trunk of the brachial plexus. Low-output impedance stimulation of the cervical spinal roots in combination with collision was used to accurately demonstrate the conduction block. Complete electrophysio...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1041

    authors: Watson BV,Nicolle MW,Brown JD

    更新日期:2001-04-01 00:00:00

  • Heterogeneity of muscle sizes in the lower limbs of children with cerebral palsy.

    abstract:INTRODUCTION:Cerebral palsy (CP) is associated with reduced muscle volumes, but previous studies have reported deficits in only a small number of muscles. The extent of volume deficits across lower limb muscles is not known. This study presents an imaging-based assessment of muscle volume and length deficits in 35 lowe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24972

    authors: Handsfield GG,Meyer CH,Abel MF,Blemker SS

    更新日期:2016-06-01 00:00:00

  • The spread of transgene expression at the site of gene construct injection.

    abstract::Seven 2-day-old golden retriever pups were given focal intramuscular injections of a first generation adenovirus-dystrophin minigene construct and adenovirus-beta-galactosidase construct as a 2:1 mixture into the left anterior tibial muscle. The spread of transgene expression within the anterior tibial muscle was comp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1031

    authors: O'Hara AJ,Howell JM,Taplin RH,Fletcher S,Lloyd F,Kakulas B,Lochmüller H,Karpati G

    更新日期:2001-04-01 00:00:00

  • Inflammatory processes in amyotrophic lateral sclerosis.

    abstract::Neuroinflammation is a characteristic of pathologically affected tissue in several neurodegenerative disorders. These changes can be observed in the brainstem and spinal cord of amyotrophic lateral sclerosis (ALS) cases and in mouse models of the disease. They include an accumulation of large numbers of activated micr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.10191

    authors: McGeer PL,McGeer EG

    更新日期:2002-10-01 00:00:00

  • Dystrophin gene transcripts skipping the mdx mutation.

    abstract::The mdx mouse, an animal model used to study Duchenne muscular dystrophy, has a nonsense mutation in exon 23 of the dystrophin gene which should result in a truncated protein that cannot be correctly localized at the sarcolemma of the muscle fibers. Immunohistochemical staining with antidystrophin antibodies has shown...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199706)20:6<728::aid-mus10

    authors: Wilton SD,Dye DE,Laing NG

    更新日期:1997-06-01 00:00:00