A comprehensive model of spastic hypertonia derived from the pendulum test of the leg.

Abstract:

:We propose a comprehensive model of spastic hypertonia based on clinical neurophysiology and validated using experimental data obtained from the pendulum test of the leg in 8 healthy volunteers and 15 spastic patients. This nonlinear computational model includes mechanical parameters and a stretch reflex representation involving three neural parameters: a threshold coefficient, the gain of the stretch reflex, and a time lag accounting for the reflex loop latency and the electromechanical coupling delay. Variation of the threshold coefficient alone allowed an overall reproduction of experimental data obtained from spastic and healthy subjects. We propose that this parameter could represent the supraspinal drive, supposed to be preserved in control subjects and decreased in spastic patients. No subsequent variation of the reflex gain was required to simulate spastic traces. Adjustment of the time lag influenced the duration of the swinging phase and oscillatory phenomena possibly occurring during the pendulum test. It could be related to the involvement of either short- or long-latency stretch reflex loops. With respect to current neurophysiological concepts of motor control, this modeling approach may help in understanding mechanisms underlying spastic hypertonia, and in predicting the clinical effect of antispasticity agents.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Le Cavorzin P,Poudens SA,Chagneau F,Carrault G,Allain H,Rochcongar P

doi

10.1002/mus.1196

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1612-21

issue

12

eissn

0148-639X

issn

1097-4598

pii

10.1002/mus.1196

journal_volume

24

pub_type

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