Abstract:
INTRODUCTION:Livedoid vasculopathy is a rare dermatological condition characterized by painful ulceration, atrophic scarring, and persistent livedo reticularis. The pathogenesis is unclear. METHODS:We report a patient with biopsy-proven livedoid vasculopathy who developed a progressive sensory ganglionopathy with profound sensory ataxia. Serial nerve conduction assessments were undertaken. RESULTS:Combined treatment with prednisolone and mycophenolate mofetil failed to control the ganglionopathy. After addition of rituximab, both symptoms and nerve conduction studies showed stabilization. CONCLUSIONS:Sensory ganglionopathies associated with autoimmune and inflammatory conditions may be characterized by a sub-population of "sick" dorsal root ganglia that can be rescued with aggressive immunotherapy.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Alix JJ,Hadjivassiliou M,Ali R,Slater D,Messenger AG,Rao DGdoi
10.1002/mus.24452subject
Has Abstractpub_date
2015-02-01 00:00:00pages
296-301issue
2eissn
0148-639Xissn
1097-4598journal_volume
51pub_type
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