Abstract:
INTRODUCTION:The aim of this study was to determine factors affecting health-related quality of life (HRQOL) and to propose appropriate treatment targets for patients with myasthenia gravis (MG). METHODS:We evaluated 640 consecutive patients with MG seen at 11 neurological centers. Two-year follow-up data were obtained for 282 patients. Correlations between detailed clinical factors and the Japanese version of the 15-item MG-specific QOL scale score were analyzed. RESULTS:In a cross-sectional analysis of 640 MG patients, multivariate regression revealed that disease severity, as evaluated by the MG Composite (P<0.0001), total dose of oral prednisolone during the last year (P=0.002), and Cushingoid appearance index (P=0.0004), showed significant negative effects on HRQOL, but the quantitative MG score and current prednisolone dose did not. CONCLUSIONS:Achieving minimal manifestations (MM) status or better with prednisolone ≤ 5 mg/day was found to exert a major positive impact on HRQOL in both the cross-sectional and 2-year follow-up patient samples and can be recommended as a treatment target.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Utsugisawa K,Suzuki S,Nagane Y,Masuda M,Murai H,Imai T,Tsuda E,Konno S,Nakane S,Suzuki Y,Fujihara K,Suzuki Ndoi
10.1002/mus.24213subject
Has Abstractpub_date
2014-10-01 00:00:00pages
493-500issue
4eissn
0148-639Xissn
1097-4598journal_volume
50pub_type
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