Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy.

Abstract:

INTRODUCTION:Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles. METHODS:Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient. RESULTS:A 48-year-old woman with a 5-year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial M2 antibodies were detected, and PBC was diagnosed. A biceps brachii biopsy specimen showed mild, non-specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial M2 antibodies was confirmed. CONCLUSIONS:In myositis patients with antimitochondrial M2 antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Uenaka T,Kowa H,Sekiguchi K,Nagata K,Ohtsuka Y,Kanda F,Toda T

doi

10.1002/mus.23730

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

766-8

issue

5

eissn

0148-639X

issn

1097-4598

journal_volume

47

pub_type

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