Fatigue trends in and the diagnosis of myasthenia gravis by frequency analysis of EMG interference patterns.


:Twenty patients with myasthenia gravis were studied. Needle interference patterns at maximal isometric contractions were recorded from the biceps brachii muscles. Each recording lasted for 30 seconds and induced some fatigue. The EMG signals were transformed into power spectra and were analyzed for differences between control and myasthenic fatigue trends and were tested for the power of the frequency variables to classify unknown subjects. Both groups showed a similar averaged spectra for the first 5 seconds. Thereafter, the controls manifested continuous increase in power, and a power peak frequency shift, toward low frequencies. The myasthenics showed an initial increase throughout the frequency ranges; however, later, there was a marked decrease in power and their peak frequency shifted toward the lower frequencies. These fatigue trends differed significantly from one another. Discriminant analysis correctly classified 83% of the subjects. This technique may be helpful in the diagnosis of myasthenia gravis.


Muscle Nerve


Muscle & nerve


Yaar I,Mitz AR,Pottala EW




Has Abstract


1985-05-01 00:00:00












  • Impact of expiratory strength training in amyotrophic lateral sclerosis: Results of a randomized, sham-controlled trial.

    abstract:INTRODUCTION:The purpose of this study was to determine the impact of an in-home expiratory muscle strength training (EMST) program on pulmonary, swallow, and cough function in individuals with amyotrophic lateral sclerosis (ALS). METHODS:EMST was tested in a prospective, single-center, double-blind, randomized, contr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验


    authors: Plowman EK,Tabor-Gray L,Rosado KM,Vasilopoulos T,Robison R,Chapin JL,Gaziano J,Vu T,Gooch C

    更新日期:2019-01-01 00:00:00

  • Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy.

    abstract::We used Southern blot analysis and the polymerase chain reaction to analyze the tissue distribution of multiple mitochondrial DNA (mtDNA) deletions in a 45-year-old man with familial mitochondrial myopathy-Southern blots showed two major types of abnormal mtDNA with approximately 4- and 8-kilobase deletions in the ske...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kawashima S,Ohta S,Kagawa Y,Yoshida M,Nishizawa M

    更新日期:1994-07-01 00:00:00

  • Developing normalized strength scores for neuromuscular research.

    abstract:INTRODUCTION:The Accurate Test of Limb Isometric Strength (ATLIS) device can reliably measure the strength of 12 muscle groups using a fixed load cell. The purpose of this study was to analyze ATLIS data from healthy adults to calculate an individual's predicted strength scores. METHODS:ATLIS data were collected from ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Andres PL,English R,Mendoza M,Florence J,Malkus E,Schierbecker J,Siener C,Malspeis S,Schoenfeld DA,Munsat TL,Cudkowicz ME

    更新日期:2013-02-01 00:00:00

  • Coincident membranous glomerulonephritis and chronic inflammatory demyelinating polyradiculoneuropathy: questioning the autoimmunity hypothesis.

    abstract::Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and membranous glomerulonephritis (MGN) are both autoimmune disorders that are rarely observed concurrently. We describe a patient who developed MGN nearly 20 years after the onset of CIDP, resulting in a secondary progression of his neuropathy. He respo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Smyth S,Menkes DL

    更新日期:2008-01-01 00:00:00

  • Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia.

    abstract::We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Siebner HR,Dressnandt J,Auer C,Conrad B

    更新日期:1998-09-01 00:00:00

  • Recurrent idiopathic lumbosacral plexopathy.

    abstract::Recurrent idiopathic lumbosacral plexopathy has rarely been reported in the literature. The present report describes a 59-year-old man presenting with recurrent episodes of acute leg pain, followed by weakness. After each episode, symptoms progressed for several months before peaking. Thereafter, gradual recovery ensu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Yee T

    更新日期:2000-09-01 00:00:00

  • Failure to detect HTLV-I by in situ hybridization in the biopsied muscles of viral carriers with polymyositis.

    abstract::Direct infection of muscle fibers by human T-lymphotropic virus type I (HTLV-I) has recently been reported in a patient with polymyositis infected with both HTLV-I and human immunodeficiency virus (HIV). Coinfections of these viruses are frequently found in the United States. In Kagoshima, Japan, patients with polymyo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Higuchi I,Nerenberg M,Yoshimine K,Yoshida M,Fukunaga H,Tajima K,Osame M

    更新日期:1992-01-01 00:00:00

  • Neural influence on slow muscle properties: inactivity with and without cross-reinnervation.

    abstract::The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Roy RR,Eldridge L,Baldwin KM,Edgerton VR

    更新日期:1996-06-01 00:00:00

  • Modeling functional decline over time in sporadic inclusion body myositis.

    abstract:INTRODUCTION:The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). METHODS:Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. The...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Alfano LN,Yin H,Dvorchik I,Maus EG,Flanigan KM,Mendell JR,Lowes LP

    更新日期:2017-04-01 00:00:00

  • Electrophysiologic investigation of thallium poisoning.

    abstract::Electrophysiologic findings in thallium intoxication are usually untimely, limited in extent, and often uninformative. This report documents serial conduction and electromyographic findings in a case of thallium poisoning, beginning 10 days after symptom onset and ending 24 months later. Initially, the plantar nerves ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Dumitru D,Kalantri A

    更新日期:1990-05-01 00:00:00

  • Repeatability, consistency, and accuracy of hand-held dynamometry with and without fixation for measuring ankle plantarflexion strength in healthy adolescents and adults.

    abstract:INTRODUCTION:Hand-held dynamometry (HHD) is commonly used to measure ankle plantarflexion strength but has variable reliability measuring higher forces. Fixed HHD is suggested to improve reliability. We, therefore, compared the reliability, consistency, and accuracy of measuring plantarflexion strength. METHODS:Planta...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Davis PR,McKay MJ,Baldwin JN,Burns J,Pareyson D,Rose KJ

    更新日期:2017-11-01 00:00:00

  • F- and M-wave conduction velocity in amyotrophic lateral sclerosis.

    abstract::The F-wave was used to estimate motor nerve conduction velocity (MNCV) along the proximal segment of the fastest axons of the deep peroneal nerve (anterior-horn cells to knee) in 13 patients with amyotrophic lateral sclerosis (ALS) and in 21 age- and sex-matched control subjects. Measurements were based on the shortes...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Argyropoulos CJ,Panayiotopoulos CP,Scarpalezos S

    更新日期:1978-11-01 00:00:00

  • Biochemical functioning of mitochondria in normal and denervated mammalian skeletal muscle.

    abstract::Mitochondrial preparations derived from denervated rat skeletal muscle and paired control muscle are characterized with respect to their oxidative and phosphorylative capacities. Our data indicate that there is an impairment within the first 2 energy coupling regions of the respiratory chain and within the ATPase comp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Joffe M,Savage N,Isaacs H

    更新日期:1981-11-01 00:00:00

  • Myasthenia gravis: a personal view of pathogenesis and mechanism, part 2.

    abstract::A review of our current knowledge of the etiology and pathogenesis of myasthenia gravis is presented, with particular emphasis on the immunological aspects of the disease. Part 1, published in the January/February issue of MUSCLE & NERVE, dealt with the clinical and genetic features of myasthenia gravis which led to t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Simpson JA

    更新日期:1978-03-01 00:00:00

  • Interaction of thyroid state and denervation on skeletal myosin heavy chain expression.

    abstract::The goal of this study was to examine the effects of altered thyroid state and denervation (Den) on skeletal myosin heavy chain (MHC) expression in the plantaris and soleus muscles. Rats were subjected to unilateral denervation (Den) and randomly assigned to one of three groups: (1) euthyroid; (2) hyperthyroid; (3) an...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Haddad F,Arnold C,Zeng M,Baldwin K

    更新日期:1997-12-01 00:00:00

  • Parenteral branched-chain amino acid treatment and avian dystrophy.

    abstract::Genetically homozygous line 413 dystrophic chickens were given twice-daily intraperitoneal injections of solutions containing branched-chain amino acids (BCCA-leucine, valine, isoleucine) either alone or in combination; and their alpha-ketoacid analogs (alpha-ketoisocaproic and alpha-ketoisovaleric acids). Another tri...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Hudecki MS,Pollina CM,Heffner RR

    更新日期:1982-07-01 00:00:00

  • Nemaline body myopathy caused by a novel mutation in troponin T1 (TNNT1).

    abstract:INTRODUCTION:Nemaline myopathy is a rare disorder characterized by skeletal muscle weakness of varying severity and onset, with the presence of nemaline rods on muscle biopsy. Congenital nemaline body myopathy due to mutations in TNNT1 has hitherto only been described as a result of a single founder mutation in patient...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Abdulhaq UN,Daana M,Dor T,Fellig Y,Eylon S,Schuelke M,Shaag A,Elpeleg O,Edvardson S

    更新日期:2016-04-01 00:00:00

  • Multiple descending corticospinal volleys demonstrated by changes of the wrist flexor H-reflex to magnetic motor cortex stimulation in intact human subjects.

    abstract::To study noninvasively multiple descending volleys on alpha motoneurons, we used a 30-50% maximum H-reflex in the wrist flexor muscle conditioned by a subthreshold magnetic stimulus of the contralateral motor cortex as a parameter of motoneuronal excitability in seven neurologically healthy subjects. The time interval...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: van der Linden C,Bruggeman R

    更新日期:1993-04-01 00:00:00

  • Inhibition of dynamic thigh muscle contraction by electrical stimulation of the posterior cruciate ligament in humans.

    abstract::We investigated the influence of electrical stimulation of the posterior cruciate ligament (PCL) on the motoneuron pool of the thigh muscle during voluntary static and dynamic muscle contraction. The study group comprised nine young men with no history of injury to the knee joints. Multistranded Teflon-insulated stain...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Fischer-Rasmussen T,Krogsgaard M,Jensen DB,Dyhre-Poulsen P

    更新日期:2001-11-01 00:00:00

  • Recommendations for myasthenia gravis clinical trials.

    abstract::The recommendations for clinical research standards published in 2000 by a task force of the Medical Scientific Advisory Board (MSAB) of the Myasthenia Gravis Foundation of America (MGFA) were largely successful in introducing greater uniformity in the recording and reporting of MG clinical trials. Recognizing that ch...

    journal_title:Muscle & nerve

    pub_type: 共识发展会议,杂志文章


    authors: Benatar M,Sanders DB,Burns TM,Cutter GR,Guptill JT,Baggi F,Kaminski HJ,Mantegazza R,Meriggioli MN,Quan J,Wolfe GI,Task Force on MG Study Design of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America

    更新日期:2012-06-01 00:00:00

  • Myasthenia gravis associated with HTLV-I infection and atypical brain lesions.

    abstract::We report a patient who experienced progressive diplopia and distal weakness of the upper limbs. Magnetic resonance imaging of the brain showed extensive white matter lesions and analysis of cerebrospinal fluid revealed acute human T-lymphotropic virus type I (HTLV-I) infection. Myasthenia gravis (MG) was evidenced by...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Lalive PH,Allali G,Truffert A

    更新日期:2007-04-01 00:00:00

  • Distal sensory nerve conduction of the superficial peroneal nerve: new method and its clinical application.

    abstract::The superficial peroneal nerve subserves sensation on the entire surface of the dorsum of the foot, except in small areas. All previously reported techniques for evaluating nerve conduction along this nerve tested a proximal portion of the nerve. We report a new method for evaluating sensory nerve conduction of the fo...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Oh SJ,Demirci M,Dajani B,Melo AC,Claussen GC

    更新日期:2001-05-01 00:00:00

  • Probabilistic muscle characterization using QEMG: application to neuropathic muscle.

    abstract::Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting musc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Pino LJ,Stashuk DW,Boe SG,Doherty TJ

    更新日期:2010-01-01 00:00:00

  • Persistent multifocal conduction block in vasculitic neuropathy with IgM anti-gangliosides.

    abstract::A 30-year-old man with essential cryoglobulinemia presented with an axonal neuropathy and was found to have vasculitis at nerve biopsy. After 44 months, in accord with clinical deterioration, motor conduction studies showed excessive temporal dispersion multifocally, with partial conduction block persisting for 3 year...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Notturno F,Caporale CM,Di Muzio A,Uncini A

    更新日期:2007-10-01 00:00:00

  • Ultrasound elastography assessment of the median nerve in leprosy patients.

    abstract:INTRODUCTION:We sought to compare median nerve elasticity between leprosy patients (LPs) and healthy volunteers (HVs) using ultrasound elastography (UE). METHODS:Two radiologists independently measured the strain ratio of the median nerve/flexor digitorum superficialis muscle (MN/FDSM) of 18 LP and 18 HV using real-ti...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Nogueira-Barbosa MH,Lugão HB,Gregio-Júnior E,Crema MD,Kobayashi MTT,Frade MAC,Pavan TZ,Carneiro AAO

    更新日期:2017-09-01 00:00:00

  • Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis.

    abstract::To determine whether skeletal muscle oxidative metabolism is impaired in multiple sclerosis (MS), phosphorus magnetic resonance spectroscopy was used to measure the rate of intramuscular phosphocreatine (PCr) resynthesis following exercise in MS and controls. Thirteen MS patients underwent intermittent isometric tetan...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kent-Braun JA,Sharma KR,Miller RG,Weiner MW

    更新日期:1994-08-01 00:00:00

  • Effects of treadmill training on microvascular remodeling in the rat after spinal cord injury.

    abstract:INTRODUCTION:The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. METHOD:Female Sprague-Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kissane RWP,Wright O,Al'Joboori YD,Marczak P,Ichiyama RM,Egginton S

    更新日期:2019-03-01 00:00:00

  • Focal myositis presenting with radial nerve palsy.

    abstract::Focal myositis is a rare inflammatory pseudotumor of skeletal muscle which usually has a benign course. We report a 56-year-old woman with a painful mass in the left arm with a radial nerve palsy. Magnetic resonance imaging (MRI) of the left arm showed a mass in the triceps muscle that was suggestive of a soft-tissue ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Alzagatiti BI,Bertorini TE,Horner LH,Maccarino VS,O'Brien T

    更新日期:1999-07-01 00:00:00

  • Inaccurate projection of rat soleus motoneurons: a comparison of nerve repair techniques.

    abstract::The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transection injuries to the sciatic nerve, and 2) to determine whether repair of a transected nerve with a silicone tube leads to greater specificity of reinnervation and recovery ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Bodine-Fowler SC,Meyer RS,Moskovitz A,Abrams R,Botte MJ

    更新日期:1997-01-01 00:00:00

  • Spinal irradiation does not inhibit distal axonal sprouting.

    abstract::In an attempt to determine the relative importance of the nerve cell body and of the axon in initiating and controlling axonal regeneration, nerve cell bodies were irradiated and the ability of the distal axon to sprout was examined. Mice were subjected to either 25 or 50 Gray (Gy) of x-irradiation localized to the lu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Pamphlett RS

    更新日期:1988-05-01 00:00:00