Fatigue trends in and the diagnosis of myasthenia gravis by frequency analysis of EMG interference patterns.


:Twenty patients with myasthenia gravis were studied. Needle interference patterns at maximal isometric contractions were recorded from the biceps brachii muscles. Each recording lasted for 30 seconds and induced some fatigue. The EMG signals were transformed into power spectra and were analyzed for differences between control and myasthenic fatigue trends and were tested for the power of the frequency variables to classify unknown subjects. Both groups showed a similar averaged spectra for the first 5 seconds. Thereafter, the controls manifested continuous increase in power, and a power peak frequency shift, toward low frequencies. The myasthenics showed an initial increase throughout the frequency ranges; however, later, there was a marked decrease in power and their peak frequency shifted toward the lower frequencies. These fatigue trends differed significantly from one another. Discriminant analysis correctly classified 83% of the subjects. This technique may be helpful in the diagnosis of myasthenia gravis.


Muscle Nerve


Muscle & nerve


Yaar I,Mitz AR,Pottala EW




Has Abstract


1985-05-01 00:00:00












  • The familial occurrence of carpal tunnel syndrome.

    abstract::Epidemiological studies of the carpal tunnel syndrome have generally overlooked the possibility of a familial occurrence. A prospective study was undertaken to determine the prevalence and significance of a positive family history of carpal tunnel syndrome. Seventy-five of 253 women and 40 of 168 men with a confirmed ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Radecki P

    更新日期:1994-03-01 00:00:00

  • Do acetylcholine receptor and striated muscle antibodies predict the presence of thymoma in patients with myasthenia gravis?

    abstract:INTRODUCTION:Acetylcholine receptor (AChR) and striated muscle antibodies (StrAbs) are found frequently in myasthenia gravis (MG) patients with thymoma. In this study we aimed to determine the positive predictive value (PPV) and negative predictive value (NPV) of these antibodies for thymoma in patients with MG. METHO...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Choi Decroos E,Hobson-Webb LD,Juel VC,Massey JM,Sanders DB

    更新日期:2014-01-01 00:00:00

  • Did giant mitochondria delay muscle maturation? An uncommon congenital myopathy.

    abstract:INTRODUCTION:Mitochondria are semi-autonomous organelles that are able to change their shape, size, location, and number inside the living cell. Mitochondrial division is an extremely important process, because cell survival depends on there being an adequate number of mitochondria in each cell. The dynamics of these o...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Fidziańska A,Glinka Z

    更新日期:2012-07-01 00:00:00

  • Growth and denervation response of skeletal muscle fibers of newborn rats.

    abstract::The cross-sectional area of the fibers of hindlimb muscles of rats increased 10-40 times during the first 6 weeks after birth. Denervation at birth stopped the growth of the muscle fibers. The number of satellite cells decreased, and eventually all fibers vanished. Reinnervation, if any, was poor. Partial denervation ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Schmalbruch H

    更新日期:1990-05-01 00:00:00

  • Time and frequency domain analysis of acoustic signals from a human muscle.

    abstract::We wished to determine whether evoked force output from a human muscle could be inferred from the amplitude and the frequency of evoked muscular sounds. Sounds from adductor pollicis were recorded with a microphone and compared to evoked force changes produced by varying the intensity of nerve stimulation or of volunt...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Chen D,Durand LG,Bellemare F

    更新日期:1997-08-01 00:00:00

  • Diffuse large B-cell lymphoma presenting as piriformis syndrome.

    abstract::Piriformis syndrome (PS) is a rare condition characterized by pain and paresthesia of the buttock, often radiating to the posterior thigh. A patient with sciatica that was clinically suspicious for PS, underwent diagnostic work-up. A diagnosis of diffuse large B-cell lymphoma with neurolymphomatosis (NL) was made. To ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Ye BS,Sunwoo IN,Suh BC,Park JP,Shim DS,Kim SM

    更新日期:2010-03-01 00:00:00

  • Poisson distribution to analyze near-threshold motor evoked potentials.

    abstract::Motor unit action potentials (MUAPs) evoked by repetitive, low-intensity transcranial magnetic stimulation can be modeled as a Poisson process. A mathematical consequence of such a model is that the ratio of the variance to the mean of the amplitudes of motor evoked potentials (MEPs) should provide an estimate of the ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kaelin-Lang A,Conforto AB,Z'Graggen W,Hess CW

    更新日期:2010-11-01 00:00:00

  • Electromyographic and lower extremity short time to inversion recovery magnetic resonance imaging findings in lumbar radiculopathy.

    abstract::To determine if short TI (time to inversion) recovery (STIR) magnetic resonance imaging (MRI) is useful in assessing lower extremity (LE) denervation in subacute lumbar radiculopathy (LR), 25 subjects underwent lumbar spine MRI, LE STIR MRI and needle electromyography (EMG). In 23 (92%) subjects there was a positive c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Carter GT,Fritz RC

    更新日期:1997-09-01 00:00:00

  • Neural influence on slow muscle properties: inactivity with and without cross-reinnervation.

    abstract::The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Roy RR,Eldridge L,Baldwin KM,Edgerton VR

    更新日期:1996-06-01 00:00:00

  • AAEE minimonograph #25: Single-fiber electromyography in myasthenia gravis.

    abstract::Single-fiber electromyography (SFEMG) demonstrates abnormal jitter in virtually all (99%) patients with myasthenia gravis (MG). One muscle, the extensor digitorum communis, is abnormal in most patients with this disease, but to obtain the maximum diagnostic sensitivity, it may be necessary to examine other muscles, es...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Sanders DB,Howard JF Jr

    更新日期:1986-11-01 00:00:00

  • Clinicopathological and molecular biological studies in a patient with neurolymphomatosis.

    abstract::We describe a patient with a clinical disorder that resembled vasculitic neuropathy in which peripheral nerves were successively affected over several months, but without systemic involvement. An initial muscle biopsy near the involved nerves showed signs of nonspecific inflammation around the muscle and nerve fibers....

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kuntzer T,Lobrinus JA,Janzer RC,Ghika J,Bogousslavsky J

    更新日期:2000-10-01 00:00:00

  • Effects of hemodialysis on intraneural blood flow in end-stage kidney disease.

    abstract:INTRODUCTION:We quantified intraneural blood flow (INBF) in 18 patients with end-stage kidney disease (ESKD) and examined its relationship with nerve size, neuropathy severity, and nerve excitability parameters. METHODS:Sonographic measurements of the median nerve were performed at the same site before and after hemod...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Borire AA,Arnold R,Pussell BA,Kwai NC,Visser LH,Simon NG,Kiernan MC,Krishnan AV

    更新日期:2018-02-01 00:00:00

  • The effect of fatigue on knee position sense is not dependent upon the muscle group fatigued.

    abstract:INTRODUCTION:Muscle fatigue could have a greater impact on position sense when antagonists of the movement are fatigued. Hence, this study aimed to compare the effects of antagonist and agonist exercise-induced muscle fatigue on knee joint position sense. METHODS:This within-subjects repeated-measures study included 4...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Ribeiro F,Venâncio J,Quintas P,Oliveira J

    更新日期:2011-08-01 00:00:00

  • Avoiding false-negative nerve conduction study in ulnar neuropathy at the elbow.

    abstract:INTRODUCTION:Ulnar nerve displacement at the elbow causes overestimation of nerve conduction velocity. We hypothesized that this overestimation may cause false-negative results when the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) diagnostic criteria are used. METHODS:We investigated 9 ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Won SJ,Yoon JS,Kim JY,Kim SJ,Jeong JS

    更新日期:2011-10-01 00:00:00

  • Analysis of histopathologic and molecular pathologic findings in Czech LGMD2A patients.

    abstract::Limb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal-recessive disorder characterized by selective atrophy and progressive weakness of proximal girdle muscles. LGMD2A, the most prevalent form of LGMD, is caused by mutations in the CAPN3 gene that encodes the skeletal muscle-specific member of the calpain fa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Hermanová M,Zapletalová E,Sedlácková J,Chrobáková T,Letocha O,Kroupová I,Zámecník J,Vondrácek P,Mazanec R,Maríková T,Vohánka S,Fajkusová L

    更新日期:2006-03-01 00:00:00

  • Electrodiagnostic reference values for upper and lower limb nerve conduction studies in adult populations.

    abstract:INTRODUCTION:To address the need for greater standardization within the field of electrodiagnostic medicine, the Normative Data Task Force (NDTF) was formed to identify nerve conduction studies (NCS) in the literature, evaluate them using consensus-based methodological criteria derived by the NDTF, and identify those s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Chen S,Andary M,Buschbacher R,Del Toro D,Smith B,So Y,Zimmermann K,Dillingham TR

    更新日期:2016-09-01 00:00:00

  • Fibrillation and accelerated AChR degradation in long-term muscle organ culture.

    abstract::Evaluation of the precise molecular dynamics of endplate maintenance and reorganization has been limited by the lack of available in vitro preparations. We describe an organ culture preparation of mouse diaphragm muscle which permits long-term maintenance of muscle viability. Spontaneous fibrillations, increased level...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Wetzel DM,Salpeter MM

    更新日期:1991-10-01 00:00:00

  • The quality of life in genetic neuromuscular disease questionnaire: Rasch validation of the French version.

    abstract:INTRODUCTION:Slowly progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The Quality of Life in Genetic Neuromuscular Disease Questionnaire (QoL-gNMD) is a new health-related quality-of-life questionnaire developed for these patients. The purpose of ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究


    authors: Dany A,Rapin A,Lavrard B,Saoût V,Réveillère C,Bassez G,Tiffreau V,Péréon Y,Sacconi S,Eymard B,Dramé M,Jolly D,Novella JL,Hardouin JB,Boyer FC

    更新日期:2017-12-01 00:00:00

  • Endurance training improves skeletal muscle electrical activity in active COPD patients.

    abstract::The effect of endurance training on muscle electrical activity during general exercise testing was investigated in physically active patients with chronic obstructive pulmonary disease (COPD). Before and after rehabilitation, patients performed identical incremental exercise tests. Pulmonary gas exchange, venous lacta...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Gosselin N,Lambert K,Poulain M,Martin A,Préfaut C,Varray A

    更新日期:2003-12-01 00:00:00

  • Quantitative ultrasonography of skeletal muscles in children: normal values.

    abstract::The purpose of this study was to establish normal values of muscle thickness, ratio of muscle thickness to subcutaneous fat thickness, and muscle echo intensity in children between 11 weeks and 16 years of age. Transverse scans of four muscles were made by standardized real-time ultrasound examination. The scans were ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Scholten RR,Pillen S,Verrips A,Zwarts MJ

    更新日期:2003-06-01 00:00:00

  • Magnetic resonance imaging of peripheral nerves: differences in magnetization transfer.

    abstract:INTRODUCTION:Magnetic resonance imaging (MRI) is an excellent imaging modality for soft tissues. Magnetization transfer (MT) imaging is an MRI technique that is sensitive to the bound protons of macromolecules and therefore can aid in the assessment of nerve damage. METHODS:Measurements of the MT ratio (MTR), which pr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gambarota G,Krueger G,Theumann N,Mekle R

    更新日期:2012-01-01 00:00:00

  • The utility of a point-of-care sural nerve conduction device for detection of diabetic polyneuropathy: A cross-sectional study.

    abstract:INTRODUCTION:Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. METHODS:The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, po...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kural MA,Andersen ST,Andersen NT,Andersen H,Charles M,Finnerup NB,Jensen TS,Tankisi H

    更新日期:2019-02-01 00:00:00

  • Chronic bilateral T1 denervation in women with macromastia.

    abstract:INTRODUCTION:The objective of this study was to identify the pattern of neurological deficits and document electrophysiological changes in women with macromastia. METHODS:Patients with macromastia and neurological complaints underwent clinical evaluation and electrodiagnostic (EDx) studies of the upper limbs. RESULTS...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Ansell JR,Buchholz MC

    更新日期:2013-02-01 00:00:00

  • A new mutation in the regulatory domain of the myophosphorylase gene affecting protein dimer contact.

    abstract::We have identified a novel missense mutation in the myophosphorylase gene in a Spanish patient with McArdle's disease. The patient was homozygous for a T-to-C transition at codon 115 (L115P) in exon 3, which changed an encoded leucine (CUG) to a proline (CCG). This is the first mutation to be described in exon 3 and i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro S

    更新日期:1999-08-01 00:00:00

  • Glycerophospholipid profile alterations are associated with murine muscle-wasting phenotype.

    abstract:INTRODUCTION:Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear. METHODS:We carried out comprehensive phospholipid analyses using liqu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Senoo N,Miyoshi N,Kobayashi E,Morita A,Tanihata J,Takeda S,Miura S

    更新日期:2020-09-01 00:00:00

  • Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.

    abstract:BACKGROUND:To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double-blind randomized controlled trial. METHODS:Twenty ALS subjects were randomized to placebo and mexiletine 300 or 600 mg daily for 4 wk and asse...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Weiss MD,Macklin EA,McIlduff CE,Vucic S,Wainger BJ,Kiernan MC,Goutman SA,Goyal NA,Rutkove SB,Ladha SS,Chen IA,Harms MB,Brannagan TH,Lacomis D,Zivkovic S,Ma M,Wang LH,Simmons Z,Rivner MH,Shefner JM,Cudkowicz ME,A

    更新日期:2020-12-19 00:00:00

  • Electrophysiological studies in a mouse model of Schwartz-Jampel syndrome demonstrate muscle fiber hyperactivity of peripheral nerve origin.

    abstract::Schwartz-Jampel syndrome (SJS) is an autosomal-recessive condition characterized by muscle stiffness and chondrodysplasia. It is due to loss-of-function hypomorphic mutations in the HSPG2 gene that encodes for perlecan, a proteoglycan secreted into the basement membrane. The origin of muscle stiffness in SJS is debate...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Echaniz-Laguna A,Rene F,Marcel C,Bangratz M,Fontaine B,Loeffler JP,Nicole S

    更新日期:2009-07-01 00:00:00

  • Confocal analysis of the dystrophin protein complex in muscular dystrophy.

    abstract::The dystrophin protein complex (DPC), composed of at least 10 proteins that associate with dystrophin, is critical for the maintenance of normal muscle fiber structure and physiology. In this study, we used immunohistochemistry and confocal microscopy to examine the relative abundance and distribution of several of th...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Draviam R,Billington L,Senchak A,Hoffman EP,Watkins SC

    更新日期:2001-02-01 00:00:00

  • Translation and validation of the arabic version of the revised 15-item myasthenia gravis quality-of-life questionnaire.

    abstract:INTRODUCTION:We sought to translate, culturally adapt, and assess the Arabic version of the 15-item myasthenia gravis quality-of-life revised scale (MGQOL15R). METHODS:We assessed reliability with Cronbach α; reproducibility with intraclass correlation coefficient (ICC); validity with Spearman correlations for myasthe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Alanazy MH,Abuzinadah AR,Muayqil T

    更新日期:2018-04-01 00:00:00

  • The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study.

    abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren. Placebo arm data (N = 57) provided insight into the natural history of the 6-minute walk test (6MWT) and other endpoints. ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: McDonald CM,Henricson EK,Abresch RT,Florence JM,Eagle M,Gappmaier E,Glanzman AM,PTC124-GD-007-DMD Study Group.,Spiegel R,Barth J,Elfring G,Reha A,Peltz S

    更新日期:2013-09-01 00:00:00