Fatigue trends in and the diagnosis of myasthenia gravis by frequency analysis of EMG interference patterns.

abstract：:In this study we present 3 families with malignant hyperthermia (MH), all of Indian subcontinent descent. One individual from each of these families was fully sequenced for RYR1 and presented with the non-synonymous change c.11315G>A/p.R3772Q. When present in the homozygous state c.11315*A is associated with myopathic...

journal_title：Muscle & nerve

authors： Carpenter D,Ismail A,Robinson RL,Ringrose C,Booms P,Iles DE,Halsall PJ,Steele D,Shaw MA,Hopkins PM

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:In this study we assessed the effect of paired stimuli on the latencies and amplitudes of the blink reflex. METHODS:Blink reflexes were performed with single and paired (5-ms interstimulus interval) stimuli in 47 patients. The changes in latencies between paired and single stimuli were calculated. RESULT...

journal_title：Muscle & nerve

authors： Rubin DI,Dimberg EL,Kennelly KD

更新日期：2011-08-01 00:00:00

abstract：:We measured the peak voltage induced in a sensing loop by a Magstim 200 magnetic stimulator. Coil output varied little for repeated stimulation at the same intensity over a wide range of coil output. In contrast, the first stimulus immediately after a change in intensity was of larger amplitude and showed greater vari...

journal_title：Muscle & nerve

authors： Reutens DC,MacDonell RA,Berkovic SF

更新日期：1993-12-01 00:00:00

abstract：:When an active muscle is stretched, the force increases due to strain of contractile and noncontractile proteins. We examined this force enhancement in rat extensor digitorum longus (EDL) and soleus muscles, which differ in their composition of these proteins, and their susceptibility to damage. Small stretches were a...

journal_title：Muscle & nerve

authors： Ramsey KA,Bakker AJ,Pinniger GJ

更新日期：2010-11-01 00:00:00

abstract：:This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...

journal_title：Muscle & nerve

authors： Schotland DL,Fieles W,Barchi RL

更新日期：1991-02-01 00:00:00

abstract：:The clinical effect of carbamazepine (CBZ) on neuromuscular transmission is described in two children who presented in coma with diffuse hypotonia and areflexia following CBZ overdose. Repetitive nerve stimulation (RNS) showed a decremental response only at high-frequency stimulation. With supportive care, the patient...

journal_title：Muscle & nerve

authors： Zaidat OO,Kaminski HJ,Berenson F,Katirji B

更新日期：1999-09-01 00:00:00

abstract：:The diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) relies primarily on clinical and electrophysiologic examination, but the nerve biopsy findings may be supportive, especially in atypical cases. In order to define the usefulness of nerve biopsy in this disease, we retrospectively studied 44 cons...

journal_title：Muscle & nerve

authors： Vallat JM,Tabaraud F,Magy L,Torny F,Bernet-Bernady P,Macian F,Couratier P

更新日期：2003-04-01 00:00:00

abstract：:Mutations of the valosin-containing protein gene (VCP) are responsible for autosomal-dominant hereditary inclusion-body myopathy associated with frontotemporal dementia and Paget's disease of bone. We identified the p.R155C missense mutation in the VCP gene segregating in an Italian family with three affected siblings...

journal_title：Muscle & nerve

authors： Gidaro T,Modoni A,Sabatelli M,Tasca G,Broccolini A,Mirabella M

更新日期：2008-01-01 00:00:00

abstract：:The mutual links between muscle pain and resting electromyographic (EMG) activity are still controversial. This study described effects of experimental muscle pain on resting EMG activity in a jaw-closing muscle and a leg muscle. Pain was induced by injections of hypertonic saline into the muscles in 10 subjects. Inje...

journal_title：Muscle & nerve

authors： Svensson P,Graven-Nielsen T,Matre D,Arendt-Nielsen L

更新日期：1998-11-01 00:00:00

abstract：:The aim of this study was to investigate the fasciculation potentials (FPs) in the small-peripheral muscles of the foot and hand and the possible associated factors, in a healthy population. One hundred-twenty-two normal individuals (65 men and 57 women), aged 17-67 years (mean 39.96, SD=12.76) participated in the stu...

journal_title：Muscle & nerve

authors： Mitsikostas DD,Karandreas N,Coutsopetras P,Piperos P,Lygidakis C,Papageorgiou C

更新日期：1998-04-01 00:00:00

abstract：:The first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles are innervated by the same ulnar nerve, but studies have shown that the former is much more severely affected in amyotrophic lateral sclerosis. In this study, threshold tracking was used to investigate whether membrane properties differ betwe...

journal_title：Muscle & nerve

authors： Bae JS,Sawai S,Misawa S,Kanai K,Isose S,Kuwabara S

更新日期：2009-03-01 00:00:00

abstract：:Three well-characterized antimyosin heavy chain monoclonal antibodies (McAbs) were used as immunocytochemical reagents to study myosin isoform expression in relationship to adenosine triphosphatase (ATPase) defined fiber types in human muscle. The biopsy specimens were from patients with neurogenic muscle disease whos...

journal_title：Muscle & nerve

authors： Sawchak JA,Lewis S,Shafiq SA

更新日期：1989-08-01 00:00:00

abstract：INTRODUCTION:Venous access for therapeutic plasma exchange (TPE) in myasthenia gravis (MG) can be achieved by central venous catheters (CVC) or peripheral veins (PV), and the preferred method varies among providers. We evaluated our institutional experience with TPE venous access method and complications. METHODS:We r...

journal_title：Muscle & nerve

authors： Guptill JT,Oakley D,Kuchibhatla M,Guidon AC,Hobson-Webb LD,Massey JM,Sanders DB,Juel VC

更新日期：2013-02-01 00:00:00

abstract：:Evaluation of the precise molecular dynamics of endplate maintenance and reorganization has been limited by the lack of available in vitro preparations. We describe an organ culture preparation of mouse diaphragm muscle which permits long-term maintenance of muscle viability. Spontaneous fibrillations, increased level...

journal_title：Muscle & nerve

authors： Wetzel DM,Salpeter MM

更新日期：1991-10-01 00:00:00

abstract：:It is important to know the effects of prolonged repetitive nerve stimulation (RNS) when it is used in neurophysiological studies. RNS with up to 100 supramaximal stimuli was given to the median, ulnar, and peroneal nerves of normal subjects and the ulnar nerves of subjects with early amyotrophic lateral sclerosis (AL...

journal_title：Muscle & nerve

authors： Baumann F,Henderson RD,Tremayne F,Hutchinson N,McCombe PA

更新日期：2010-06-01 00:00:00

abstract：:The reliability of motor unit number estimation (MUNE) for assessment of the long-term course of ALS is dependent on the reproducibility of the technique. We report our results with the statistical method of MUNE on the ulnar nerve/hypothenar muscle in 16 ALS patients who were studied on 52 occasions. On each occasion...

journal_title：Muscle & nerve

authors： Olney RK,Yuen EC,Engstrom JW

更新日期：2000-02-01 00:00:00

abstract：:The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barré syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also detectable in CSF from patients with other neurological diseases but were...

journal_title：Muscle & nerve

authors： Brinkmeier H,Seewald MJ,Wollinsky KH,Rüdel R

更新日期：1996-01-01 00:00:00

abstract：:Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central c...

journal_title：Muscle & nerve

authors： Jamali AA,Afshar P,Abrams RA,Lieber RL

更新日期：2000-06-01 00:00:00

abstract：:The goal of this study was to examine the effects of altered thyroid state and denervation (Den) on skeletal myosin heavy chain (MHC) expression in the plantaris and soleus muscles. Rats were subjected to unilateral denervation (Den) and randomly assigned to one of three groups: (1) euthyroid; (2) hyperthyroid; (3) an...

journal_title：Muscle & nerve

authors： Haddad F,Arnold C,Zeng M,Baldwin K

更新日期：1997-12-01 00:00:00

abstract：:Inflammatory myopathies (IMs) occur relatively frequently in dogs, and, with the exception of masticatory muscle myositis (MMM), have not been characterized. This study analyzed the distribution and types of cellular infiltrates in 21 cases of generalized IM, 3 cases of focal IM (MMM), and 1 case with features of both...

journal_title：Muscle & nerve

authors： Pumarola M,Moore PF,Shelton GD

更新日期：2004-06-01 00:00:00

abstract：:Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells. Emerging investiga...

journal_title：Muscle & nerve

authors： Zhang GX,Navikas V,Link H

更新日期：1997-05-01 00:00:00

abstract：UNLABELLED:Contemporary natural history data in Duchenne muscular dystrophy (DMD) is needed to assess care recommendations and aid in planning future trials. METHODS:The Cooperative International Neuromuscular Research Group (CINRG) DMD Natural History Study (DMD-NHS) enrolled 340 individuals, aged 2-28 years, with DM...

journal_title：Muscle & nerve

authors： McDonald CM,Henricson EK,Abresch RT,Han JJ,Escolar DM,Florence JM,Duong T,Arrieta A,Clemens PR,Hoffman EP,Cnaan A,Cinrg Investigators.

更新日期：2013-07-01 00:00:00

abstract：:Masseter muscle biopsies were obtained from nine patients undergoing orthognatic surgery or surgery for parotid tumors. A detailed enzyme-histochemical and immunocytochemical study of these muscles was performed using antibodies specific to the various isozymes of the myosin heavy chain (MHC) in order to identify the ...

journal_title：Muscle & nerve

authors： Butler-Browne GS,Eriksson PO,Laurent C,Thornell LE

更新日期：1988-06-01 00:00:00

abstract：:The goal of this study was to estimate the accuracy of concentric-needle single-fiber electromyography (CN-SFEMG) for the diagnosis of myasthenia gravis (MG). A consecutive series of patients referred for CN-SFEMG was evaluated by an investigator blinded to the results of CN-SFEMG in order to determine the presence or...

journal_title：Muscle & nerve

authors： Benatar M,Hammad M,Doss-Riney H

更新日期：2006-08-01 00:00:00

abstract：:To better define electrophysiological abnormalities in myasthenia gravis (MG) patients with muscle-specific tyrosine kinase (MuSK) antibodies (Ab), we compared electrophysiological features of 14 MuSK Ab-positive, 73 acetylcholine receptor antibody (AChR Ab)-positive, and 22 MuSK and AChR Ab-negative (seronegative) pa...

journal_title：Muscle & nerve

authors： Oh SJ,Hatanaka Y,Hemmi S,Young AM,Scheufele ML,Nations SP,Lu L,Claussen GC,Wolfe GI

更新日期：2006-04-01 00:00:00

abstract：:Ultrastructural, biochemical, and electrophysiological analyses were done on 12-14-month-old mice deficient for myelin-associated glycoprotein (MAG) to further characterize the neuropathy that develops as they age. Electron microscopy demonstrated normal myelin compaction and axonal degeneration in a large number of m...

journal_title：Muscle & nerve

authors： Weiss MD,Luciano CA,Quarles RH

更新日期：2001-10-01 00:00:00

abstract：:Since peripheral nerve has a large ischemic safety factor, hypothermia, by reducing metabolic demands, is potentially an efficacious technique to rescue nerve from ischemic fiber degeneration (IFD). We therefore evaluated the influence of temperature on the severity of IFD resulting from a standard ischemic stress. Is...

journal_title：Muscle & nerve

authors： Kihara M,Schmelzer JD,Kihara Y,Smithson IL,Low PA

更新日期：1996-02-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease is a heterogeneous group of inherited sensory and motor neuropathies. Mutations in the gene that encodes for myelin protein zero (MPZ) can produce different phenotypes: CMT1 (with low conduction velocities), CMT2 (less frequent and with unaffected conduction velocities), and CMTID (wi...

journal_title：Muscle & nerve

authors： Banchs I,Casasnovas C,Montero J,Volpini V,Martínez-Matos JA

更新日期：2010-08-01 00:00:00

abstract：:Some have suggested that nonfamilial motor neuron disease (MND) may be autoimmune, and the neurological disorder may benefit from immunotherapy. There have been reports of over 30 cases of lymphoproliferative disease (lymphoma, multiple myeloma, Waldenström's macroglobulinemia) with MND, and these patients might he of...

journal_title：Muscle & nerve

authors： Louis ED,Hanley AE,Brannagan TH,Sherman W,Murphy P,Lange DJ,Trojaborg W,Younger DS,Lovelace RE,Latov N,Rowland LP

更新日期：1996-10-01 00:00:00

abstract：:We describe a consanguineous family that had progressive myopathy with rimmed vacuole (RV) formation and amyloid deposition. Patient 1 is a 71-year-old woman with muscle atrophy in the lumbar girdle and lower extremities. Patient 2 is a 40-year-old man (the son of Patient 1) with fatty changes in the biceps femoris mu...

journal_title：Muscle & nerve

authors： Kojima Y,Sakai K,Ishida C,Asaka T,Hamaguchi T,Nozaki I,Fukushima K,Tsuchiya A,Kametani F,Yazaki M,Okino S,Yamada M

更新日期：2009-09-01 00:00:00