Abstract:
:The reliability of motor unit number estimation (MUNE) for assessment of the long-term course of ALS is dependent on the reproducibility of the technique. We report our results with the statistical method of MUNE on the ulnar nerve/hypothenar muscle in 16 ALS patients who were studied on 52 occasions. On each occasion, MUNE was performed twice with one electrode placement and once with a different placement. For each MUNE, mean surface motor unit potential amplitude was determined within three different recording ranges or windows at different stimulus intensities. The MUNE results had excellent reproducibility with coefficients of variation of 19% and test-retest correlation coefficients from 0.75 to 0.86. With examination of sources for variability, the reproducibility of statistical MUNE is not affected by minor variation in stimulation and recording electrode placement but may be improved by modifying methods for recording window selection. The high reproducibility of statistical MUNE supports its reliability for estimating the rate of motor unit loss in ALS.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Olney RK,Yuen EC,Engstrom JWdoi
10.1002/(sici)1097-4598(200002)23:2<193::aid-mus8>subject
Has Abstractpub_date
2000-02-01 00:00:00pages
193-7issue
2eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(200002)23:2<193::AID-MUS8>journal_volume
23pub_type
临床试验,杂志文章相关文献
MUSCLE & NERVE文献大全abstract:INTRODUCTION:Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are widely used drugs for hyperlipidemia and are generally well-tolerated, but the can produce skeletal muscle toxicity. The molecular mechanisms driving statin myopathy are unknown. We investigated the effects of statin treatment...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22081
更新日期:2011-09-01 00:00:00
abstract::The motor end-plate fine structure and distribution of junctional acetylcholine receptors (AChRs) in patients with amyotrophic lateral sclerosis (ALS) were studied. Morphometric analysis was carried out in 74 end-plates (92 innervated and 47 denuded postsynaptic regions) from 10 patients with ALS. AChR was studied by ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070310
更新日期:1984-03-01 00:00:00
abstract:INTRODUCTION:We evaluated the contribution of denervation-related molecular processes to rotator cuff muscle degeneration after tendon release. METHODS:We assessed the levels of myogenic (myogenin and myogenic differentiation factor [myoD]) and proadipogenic (peroxisome proliferator-activated receptor γ) transcription...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26316
更新日期:2019-01-01 00:00:00
abstract::The intramembrane particle (IMP) profile of control and dystrophic (Bio 14.6) hamster cardiac muscle plasma membrane was assessed in freeze-fracture replicas to determine whether this animal model of muscular dystrophy exhibits the same membrane characteristics found in skeletal muscle from other more thoroughly studi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070702
更新日期:1984-09-01 00:00:00
abstract::A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle ap...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160908
更新日期:1993-09-01 00:00:00
abstract:INTRODUCTION:We report preliminary findings of nerve ultrasound in patients with cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) who have sensory impairment due to dorsal root ganglionopathy. METHODS:The ultrasound cross-sectional area (CSA) of median and ulnar nerves of 7 CANVAS patients was compa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25476
更新日期:2017-07-01 00:00:00
abstract::Mitochondrial crystalline inclusions, frequently found in mitochondrial myopathies, were analyzed by crystallographic techniques and computer-aided image processing. It could be shown that these structures were real crystals. There are two distinct types of crystal, which can be distinguished by shape, size, and patte...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110109
更新日期:1988-01-01 00:00:00
abstract::Bacterial beta-galactosidase cDNA was injected without lipofectin into 41 sites in dog muscle and expression was seen in 22 of them. The cDNA and lipofectin was injected into 35 similar sites and expression was seen in 21. Expression was seen in a maximum of 2.5% of muscle fibers and 23.21% of nonmuscle cells. A total...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199802)21:2<159::aid-mus2>
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. METHOD:Female Sprague-Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26379
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Changes in subsynovial connective tissue (SSCT) in carpal tunnel syndrome (CTS) patients may result in altered dynamics; consequently, quantification of these dynamics might support objective diagnosis of CTS. METHODS:We measured and compared longitudinal excursion of the flexor digitorum superficialis an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23246
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:Contradictory reports of the myosin heavy chain (MHC) composition of adult human suprahyoid muscles leave unresolved the extent to which these muscles express developmental and unconventional MHC. METHODS:By immunohistochemistry, separation sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PA...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23946
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Pes cavus often signals the presence of Charcot-Marie-Tooth (CMT) in adult patients, although its prevalence in the general population makes it a finding of unclear significance. METHODS:We undertook a pilot double cohort study to investigate the feasibility of comparing preselected bedside and radiograph...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26309
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:In mitochondrial disease, it is likely that energy substrate depletion leads to paralysis of ATPase-dependent pumps, resulting in membrane depolarization. Axonal depolarization has been demonstrated in a crisis, but not in the resting state. We, therefore, stressed axons using ischemia to see if this would...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23733
更新日期:2013-05-01 00:00:00
abstract::Implantation of normal muscle precursor cells (mpc) for treatment for inherited myopathies such as Duchenne muscular dystrophy is in clear need of improvement to become practicable, but few variables have been studied comparatively. Here, we report the first quantitative estimate of the effectiveness of implanting mpc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199602)19:2<132::AID-MUS2>
更新日期:1996-02-01 00:00:00
abstract:INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24929
更新日期:2016-01-01 00:00:00
abstract::Immunologic syndromes are associated with hepatitis B viral (HBV) infection. However, mononeuropathy multiplex (MM), a syndrome in which immune factors may play a role, is rare in acute HBV infection. Few cases of MM associated with HBV infection have been reported. We report a case of acute HBV infection in which MM ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880130304
更新日期:1990-03-01 00:00:00
abstract::Masseter (MR) and blink reflexes (BL) were investigated in 51 patients with internuclear ophthalmoplegia (INO) due to multiple sclerosis (28) and lacunar infarction (23). The MR was abnormal in 20 of 23 cases with bilateral INO and in 21 of 28 with unilateral INO. The R1 component of the BL (BL-R1) was abnormal in 7 o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140406
更新日期:1991-04-01 00:00:00
abstract::We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies. Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatm...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.1109
更新日期:2001-08-01 00:00:00
abstract::We investigated 16 patients with Fabry's disease (eight hemizygous men and eight heterozygous women) in one family. We used constant current perception threshold (CPT) testing, which evaluated three major sensory nerve fiber populations, to assess subjective complaints of pain and paresthesias. We also examined clinic...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199911)22:11<1531::aid-mus
更新日期:1999-11-01 00:00:00
abstract::The electrical and mechanical properties of paralyzed human thenar muscles were measured in response to supramaximal stimulation of the median nerve in individuals with chronic cervical spinal cord injury. These data were compared to those recorded from control muscles. Spontaneous motor unit activity was common in pa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199707)20:7<788::aid-mus2>
更新日期:1997-07-01 00:00:00
abstract::A middle-aged male developed a right posterior femoral cutaneous neuralgia that persisted for 10 years without any associated neurologic, electrophysiologic, or radiologic findings. Five years after onset, surgical exploration of the subgluteal area identified a venous malformation surrounding the nerve. The syndrome ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880111106
更新日期:1988-11-01 00:00:00
abstract:INTRODUCTION:An environmental trigger of sporadic amyotrophic lateral sclerosis (ALS) is supported by geographic disparities in ALS incidence and development of the disease in conjugal couples. This study aims to investigate the incidence of ALS in the Northern New England states of New Hampshire (NH), Vermont (VT), an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23761
更新日期:2013-08-01 00:00:00
abstract::Data are scarce relating to the plasticity with strength training of dynamic muscle performance in older humans. Hence, we investigated alterations in the torque-velocity relation with strength training in old age, and their origin. Knee extension and leg-press exercises were performed three times per week for 14 week...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20275
更新日期:2005-03-01 00:00:00
abstract:INTRODUCTION:Premotor potentials (PMPs) precede compound muscle action potentials evoked from the second lumbrical muscle after median nerve stimulation. Although PMP has been identified as a median sensory nerve action potential, few reports have documented the significance of PMP parameters for diagnosing carpal tunn...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23424
更新日期:2012-12-01 00:00:00
abstract::Cardiotrophin-1 (CT-1) has potent survival-promoting effects on motor neurons in vitro and in vivo and may be effective in treating motor neuron diseases (MND). We investigated the effects of CT-1 treatment in wobbler mouse MND. Wobbler mice were randomly assigned to receive subcutaneously injected CT-1 (1 mg/kg, n = ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1068
更新日期:2001-06-01 00:00:00
abstract:INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25058
更新日期:2016-09-01 00:00:00
abstract::The majority of patients with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) have an A-->G mutation at nucleotide 3243 in mitochondrial transfer (t)RNA. To date there have only been 10 reported cases of MELAS syndrome in patients with a T-->C mutation at position 3271...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199801)21:1<25::aid-mus4>3
更新日期:1998-01-01 00:00:00
abstract::To enable the quantitative assessment of peripheral nerve structure and function, we determined the normal values for sural nerve hydration structure as measured by magnetic resonance proton imaging, and for neurological function with scores for neuropathic symptoms, signs, and nerve conduction properties. Normal huma...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160311
更新日期:1993-03-01 00:00:00
abstract::The diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) relies primarily on clinical and electrophysiologic examination, but the nerve biopsy findings may be supportive, especially in atypical cases. In order to define the usefulness of nerve biopsy in this disease, we retrospectively studied 44 cons...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10348
更新日期:2003-04-01 00:00:00
abstract::We measured the peak voltage induced in a sensing loop by a Magstim 200 magnetic stimulator. Coil output varied little for repeated stimulation at the same intensity over a wide range of coil output. In contrast, the first stimulus immediately after a change in intensity was of larger amplitude and showed greater vari...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880161211
更新日期:1993-12-01 00:00:00