Abstract:
:The first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles are innervated by the same ulnar nerve, but studies have shown that the former is much more severely affected in amyotrophic lateral sclerosis. In this study, threshold tracking was used to investigate whether membrane properties differ between FDI and ADM motor axons. In 12 normal subjects, compound muscle action potentials were recorded from FDI and ADM after ulnar nerve stimulation at the wrist. The strength-duration time constant was significantly longer in the FDI axons than in the ADM axons, and latent addition studies showed greater threshold changes at the conditioning-test stimulus of 0.2 ms in FDI than in ADM axons. These findings suggest that nodal persistent sodium conductances are more prominent in FDI axons than in ADM axons, and therefore excitability is physiologically higher in FDI axons. Even in the same nerve at the same sites, membrane properties of FDI and ADM motor axons differ significantly, and thus their axonal/neuronal responses to disease may also differ.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Bae JS,Sawai S,Misawa S,Kanai K,Isose S,Kuwabara Sdoi
10.1002/mus.21107subject
Has Abstractpub_date
2009-03-01 00:00:00pages
350-4issue
3eissn
0148-639Xissn
1097-4598journal_volume
39pub_type
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