Abstract:
:Two sisters with a Charcot-Marie-Tooth disease type 1A (CMT1A) duplication, who had an unusual CMT1A clinical phenotype, are described. The 63-year-old proband presented with dysesthesia on the inner side of the right leg. Neurological examination revealed a localized sensory disturbance in the lower extremities and mild weakness in the feet and left hand. Her 61-year-old sister had experienced several episodes of acute paralysis, and neurological examination showed moderate, sensory-dominant polyneuropathy. A reduction of myelinated fibers with many onion-bulb formations were observed in the sural nerve of the proband, and electrophysiological studies showed reduced motor nerve conduction velocities in both sisters. To diagnose CMT1A, we developed a CMT1A duplication test based on detection of CMT1A-specific junction fragments using the long polymerase chain reaction (PCR) method. A 3.3-kb CMT1A-specific junction fragment was detected in both patients, and their neuropathy may therefore have been associated with CMT1A duplication.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Murakami T,Oomori H,Hara A,Uyama E,Mita S,Uchino Mdoi
10.1002/(sici)1097-4598(199911)22:11<1593::aid-mussubject
Has Abstractpub_date
1999-11-01 00:00:00pages
1593-6issue
11eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199911)22:11<1593::AID-MUSjournal_volume
22pub_type
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