Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block?

Abstract:

INTRODUCTION:Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? METHODS:We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was measured at weeks 2 and 18 using the Appel Amyotrophic Lateral Sclerosis (AALS) score (includes grip and pincer strength measures), ALS Functional Rating Scale (ALSFRS), and electrophysiological measures, including motor unit estimates (MUNEs). RESULTS:No change occurred in AALS or ALSFRS scores posttreatment. Grip/pincer strength increased in 7 patients (P = 0.028) after initial treatment (responders); 2 showed no improvement (non-responders). No electrophysiological measure changed after treatment in either group but MUNEs trended higher (P = 0.055). "Abnormal A-waves" (complex, repetitive biphasic, or present in multiple nerves) occurred in pretreatment studies more often in responders (P = 0.028). DISCUSSION:"Abnormal A-waves" may signal IVIg-responsive LMN syndromes even if conduction block is absent.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Lange DJ,Nijjar R,Voustianiouk A,Seidel G,Panchal J,Wang AK

doi

10.1002/mus.21914

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

537-42

issue

4

eissn

0148-639X

issn

1097-4598

journal_volume

43

pub_type

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