Abstract:
:Influenza vaccination has been associated with adverse events including Guillain-Barré syndrome. Because the safety of influenza vaccination in patients with myasthenia gravis (MG) has not been established, some clinicians discourage vaccination for these patients. We explored whether the administration of influenza vaccine to patients with MG might increase the risk of myasthenic crisis. Using population-based healthcare data from Ontario, Canada, from 1992 to 2007, we utilized the self-matched, case-series method of detecting adverse events following vaccination. We studied patients with established myasthenia who were hospitalized for MG within 42 weeks of influenza vaccination. We defined the primary risk interval as the 6 weeks following vaccination. Between January 1, 1992 and March 31, 2006, we identified 3667 hospital admissions for MG. No seasonal trend in MG admissions was evident. In 513 instances, hospitalization occurred within 42 weeks following vaccination in patients previously diagnosed with MG. Among these patients, 266 (52%) were men, the median age was 74 years, and 86 (17%) had previously undergone thymectomy. The estimated relative incidence of admission for MG in the primary risk interval compared with the control interval was 0.84 (95% confidence interval 0.65-1.09). We found similar results in stratified analyses according to gender, age, and thymectomy status. Vaccination of patients with MG against influenza was not found to be associated with exacerbations of the disease. Our findings do not support the practice of withholding influenza vaccination in patients with MG.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Zinman L,Thoma J,Kwong JC,Kopp A,Stukel TA,Juurlink DNdoi
10.1002/mus.21440subject
Has Abstractpub_date
2009-12-01 00:00:00pages
947-51issue
6eissn
0148-639Xissn
1097-4598journal_volume
40pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a r...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.21758
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:Voltage-gated Kv1 potassium channel complex (VGKC) autoantibodies subtyped for leucine-rich glioma-inactivated 1 (LGI1), contactin-associated-proteinlike 2 (CASPR2), and Kv IgGs have a spectrum of neurological presentations. Painful polyneuropathy is seen in some patients, but nerve pathology descriptions ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25371
更新日期:2017-04-01 00:00:00
abstract::Left spinal accessory nerve palsy occurred in a young man when he quickly turned his head to the right while his shoulders were pulled down by heavy hand-held objects. Electrophysiologic studies demonstrated partial axonotmesis of the spinal accessory nerve branches innervating the sternocleidomastoid and upper and mi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110210
更新日期:1988-02-01 00:00:00
abstract:INTRODUCTION:In preparation for clinical trials we examine the validity, reliability, and patient understanding of the Myotonic Dystrophy Health Index (MDHI). METHODS:Initially we partnered with 278 myotonic dystrophy type-1 (DM1) patients and identified the most relevant questions for the MDHI. Next, we used factor a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24097
更新日期:2014-06-01 00:00:00
abstract::This article describes nerve conduction studies of the deep temporal nerve (DTN) and the mylohyoid nerve (MHN) motor branches of the trigeminal nerve. These nerves were stimulated intraorally with a pediatric surface stimulator. Compound muscle action potentials were recorded over the temporalis and mylohyoid muscles ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880190302
更新日期:1996-03-01 00:00:00
abstract::We have developed an algorithm, called multi-motor unit action potential analysis (MMA), to aid quantification in routine needle EMG examination. In only 5-8 min, it was possible to extract, analyze, and validate 20 motor unit action potentials (MUAPs). In the biceps muscle of normal subjects, the MUAP measurements ar...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880181012
更新日期:1995-10-01 00:00:00
abstract::Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100607
更新日期:1987-07-01 00:00:00
abstract::Single-fiber electromyography (SFEMG) demonstrates abnormal jitter in virtually all (99%) patients with myasthenia gravis (MG). One muscle, the extensor digitorum communis, is abnormal in most patients with this disease, but to obtain the maximum diagnostic sensitivity, it may be necessary to examine other muscles, es...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090904
更新日期:1986-11-01 00:00:00
abstract:INTRODUCTION:In this study we assessed the effect of paired stimuli on the latencies and amplitudes of the blink reflex. METHODS:Blink reflexes were performed with single and paired (5-ms interstimulus interval) stimuli in 47 patients. The changes in latencies between paired and single stimuli were calculated. RESULT...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22034
更新日期:2011-08-01 00:00:00
abstract::Genetic testing is rapidly becoming an increasingly significant part of the diagnostic armamentarium of neuromuscular clinicians. Although technically easy to order, the results of such testing, whether positive or negative, have potentially enormous consequences for the individual tested and for family members. As a ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.25400
更新日期:2016-12-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) generally presents sporadically. Epidemics of GBS are unusual. We reviewed the medical records of 26 patients hospitalized for GBS during the 2007 GBS epidemic in northeast China. The objective was to determine whether there were clinical and electrophysiological characteristics. All pati...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21701
更新日期:2010-09-01 00:00:00
abstract::This study aimed to clarify the morphologic variations of the Martin-Gruber anastomosis (MGA) by tracing the anastomotic fascicles. We used 102 upper limbs, and MGA was found in 39.2%. Among 12 instances of MGA between the branches innervating the flexor digitorum profundus muscle, eight anastomotic branches solely in...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20141
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Accuracy of needle electromyography is typically ensured by use of anatomical landmarks and auditory feedback related to voluntary activation of the targeted muscle; however, in certain clinical situations, landmarks may not be palpable, auditory feedback may be limited or not present, and targeting a spec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22008
更新日期:2011-07-01 00:00:00
abstract::Neuroinflammation is a characteristic of pathologically affected tissue in several neurodegenerative disorders. These changes can be observed in the brainstem and spinal cord of amyotrophic lateral sclerosis (ALS) cases and in mouse models of the disease. They include an accumulation of large numbers of activated micr...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.10191
更新日期:2002-10-01 00:00:00
abstract::Ultrasound has been used for visualizing peripheral nerve pathology. Our goal was to use ultrasound to quantitate the sizes of upper extremity nerves along their length in control subjects and patients with neuropathy. We measured median and ulnar nerve cross-sectional areas (NCSA) in the arms of 190 subjects, includi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21431
更新日期:2009-12-01 00:00:00
abstract:INTRODUCTION:Duration of training to reliably measure nerve cross-sectional area with ultrasound is unknown. METHODS:A retrospective review was performed of ultrasound data, acquired and recorded by 2 examiners-an expert and either a trainee with 2 months (novice) or a trainee with 12 months (experienced) of experienc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25980
更新日期:2018-02-01 00:00:00
abstract::We have assessed the reliability of hand-held myometry in 33 patients with spinal muscular atrophy (SMA), testing elbow flexion, handgrip, three-point pinch, knee flexion, knee extension, and foot dorsiflexion, and determining intraclass correlation coefficients (ICC). Interrater reliability was high for upper limbs, ...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.10166
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:Pompe disease is a progressive and debilitating neuromuscular disorder that presents with a heterogeneous array of signs and symptoms including proximal muscle weakness, respiratory insufficiency, and/or elevated creatine kinase levels. It mimics other neuromuscular disorders, making its diagnosis challeng...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23643
更新日期:2013-04-01 00:00:00
abstract::An adult male with C-7 quadriplegia developed neck pain. Axillary F central latencies were prolonged, and MRI showed a syrinx extending to C-1. After shunting, F latencies normalized. At subsequent follow-up, a rostral syrinx persisted by magnetic resonance imaging (MRI); motor evoked potential (MEP) latencies were pr...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880150702
更新日期:1992-07-01 00:00:00
abstract::Ventricular repolarization dysfunction has recently been reported in multiple sclerosis (MS). We evaluated ventricular repolarization dysfunction in 52 MS patients and looked for a relationship between corrected QT (QTc) abnormalities (i.e., abnormalities of QT intervals corrected for rate) and spinal cord magnetic re...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200008)23:8<1284::aid-mus21>3.0.
更新日期:2000-08-01 00:00:00
abstract:INTRODUCTION:Patients with DMD have low bone mineral density (BMD) and are at high risk for fractures. We examined changes in BMD and the effects of alendronate in DMD patients treated at our institution in the last decade. METHODS:Retrospective cohort study of 39 DMD patients. RESULTS:Patients had screening dual ene...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23948
更新日期:2014-04-01 00:00:00
abstract::The superficial peroneal nerve subserves sensation on the entire surface of the dorsum of the foot, except in small areas. All previously reported techniques for evaluating nerve conduction along this nerve tested a proximal portion of the nerve. We report a new method for evaluating sensory nerve conduction of the fo...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.1056
更新日期:2001-05-01 00:00:00
abstract::Earlier studies have shown that prior denervation of muscle prevents myotonia induced by 2,4-dichlorophenoxy acetic acid (2,4-D) both in vivo and in vitro. This work studied the effect of reinnervation on 2,4-D myotonia. Twenty Sprague-Dawley rats were injected with 2,4-D at specific intervals following unilateral sci...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090414
更新日期:1986-05-01 00:00:00
abstract::Motoneurons can be activated both reflexly and antidromically following electrical stimulation of peripheral nerves. These H reflexes and F waves are clinically useful responses which interface at the level of the peripheral nerves and the spinal cord. Because these responses are commonly employed in the electrodiagno...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880151102
更新日期:1992-11-01 00:00:00
abstract:INTRODUCTION:In Duchenne muscular dystrophy (DMD), fat replacement of muscle may be a useful endpoint in trials of therapy, although progression in different muscle groups is uneven. In this study we assessed the progression of fat replacement with T(1) -weighted imaging over 2 9-month periods. METHODS:Eight ambulant,...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23879
更新日期:2013-10-01 00:00:00
abstract:INTRODUCTION:Despite structural distinction between the transverse and oblique heads of the adductor pollicis, in vivo testing continues to consider the adductor pollicis as functionally simplistic. As a muscle's architecture is a strong indicator of function, in this study we aimed to determine whether the physiologic...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23933
更新日期:2014-03-01 00:00:00
abstract::Forty patients with polymyositis or dermatomyositis underwent detailed electromyographic evaluation. The paraspinal muscles of all patients were examined, as were several extremity muscles. The distribution of fibrillation potentials (FPs) in different muscles is discussed. FPs were most frequent in paraspinal muscles...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880020103
更新日期:1979-01-01 00:00:00
abstract::Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by autoantibodies against presynaptic voltage-gated calcium channels that impair neuromuscular transmission. Malignancies, especially small cell lung cancer (SCLC), have been associated with LEMS and account for approximately 60% of cases...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24122
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Evaluation of nerve mechanical properties has the potential to improve assessment of nerve impairment. Shear wave velocity, as measured by using shear wave (SW) ultrasound elastography, is a promising indicator of nerve mechanical properties such as stiffness. However, elucidation of external factors that ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26842
更新日期:2020-05-01 00:00:00
abstract::Large muscle genes are often sequenced using complementary DNA (cDNA) made from muscle messenger RNA (mRNA) to reduce the cost and workload associated with sequencing from genomic DNA. Two potential barriers are the availability of a frozen muscle biopsy, and difficulties in detecting nonsense mutations due to nonsens...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22118
更新日期:2011-08-01 00:00:00