Abstract:
:Normal motor units (MUs) were simulated and their architecture altered to simulate the changes produced by myopathy. The concentric needle electromyographic recordings of motor unit action potentials (MUAPs) from the MUs were then also simulated. These simulated MUAPs showed features that are seen in myopathy: normal amplitude and slightly reduced area, MUAPs with simple waveform and reduced duration, and complex MUAPs with normal or increased duration. The MUAP waveforms were complex because of increased variability of fiber diameter and not because of loss of muscle fibers. The MUAP duration increased when the variability of fiber diameter increased. Finally, MUAPs similar to those seen in neurogenic diseases were produced from MUs in which the only abnormality was increased variability of fiber diameter.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Nandedkar SD,Sanders DBdoi
10.1002/mus.880120306subject
Has Abstractpub_date
1989-03-01 00:00:00pages
197-202issue
3eissn
0148-639Xissn
1097-4598journal_volume
12pub_type
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