Ischemic injury and repair process after transection in hypothyroid rat muscles.

Abstract:

:Hindlimb ischemia for 4 h, followed by reperfusion, resulted in necrosis of most soleus muscle in euthyroid rats, whereas only slight damage occurred in hypothyroid rats. Muscle repair after transection of the tibialis anterior muscle of hypothyroid rats showed delayed debris removal, initial retardation of myotube formation, and a higher incidence of aberrant sarcomeres in newly formed muscle fibers by electron microscopy. The protective mechanism against ischemia in hypothyroid muscles can probably be attributed to decreased degradation of high-energy phosphates, reduced formation of substrates for xanthine oxidase during ischemia, and attenuated generation of harmful oxygen free radicals during reperfusion. Initial delay of myotube formation seems to reflect retarded proliferation of muscle precursor cells. Prolonged occurrence of aberrant sarcomeres in hypothyroidism is perhaps due to a delay or imbalance in the synthesis of proteins that assemble sarcomeres. These findings demonstrate the significant roles of thyroid hormones in ischemic injury and muscle repair.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Ozawa J,Kawamata S,Kurosaki T,Iwamizu Y,Matsuura N,Abiko S,Kai S

doi

10.1002/mus.10364

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

595-603

issue

5

eissn

0148-639X

issn

1097-4598

journal_volume

27

pub_type

杂志文章
  • Needlestick injuries among electromyographers.

    abstract::The objective of this study was to determine the self-reported prevalence of needlestick injuries among practicing electromyographers. In January 2008, an anonymous electronic survey was sent to all active members of the American Association for Neuromuscular and Electrodiagnostic Medicine (AANEM) who provided e-mail ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21118

    authors: Mateen FJ,Grant IA,Sorenson EJ

    更新日期:2008-12-01 00:00:00

  • Intranervous immunoglobulin deposits: an underestimated mechanism of neuropathy.

    abstract::There are several pathogenic mechanisms of peripheral nerve involvement in patients with monoclonal dysglobulinemia. Intranervous proliferation of malignant cells, immunoglobulin, or amyloid deposits in the endoneurial space can only be determined by examination of nerve biopsy specimens. We present clinical, electrop...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21057

    authors: Vallat JM,Magy L,Richard L,Piaser M,Sindou P,Calvo J,Ghorab K,Cros D

    更新日期:2008-07-01 00:00:00

  • Red blood cell alterations in muscular dystrophy: the role of lipids.

    abstract::Biochemical, morphologic, and biophysical studies support the concept that the red blood cell (RBC) membrane is altered in both myotonic muscular dystrophy (MyD) and Duchenne muscular dystrophy (DMD). These studies have not identified a primary metabolic defect that would explain the various alterations of membrane pr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.880030108

    authors: Plishker GA,Appel SH

    更新日期:1980-01-01 00:00:00

  • AAEM minimonograph #34: polyneuropathy: classification by nerve conduction studies and electromyography.

    abstract::Electrodiagnostic evaluation of patients with suspected polyneuropathy is useful for detecting and documenting peripheral abnormalities, identifying the predominant pathophysiology, and determining the prognosis for certain disorders. The electrodiagnostic classification of polyneuropathy is associated with morphologi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.880131002

    authors: Donofrio PD,Albers JW

    更新日期:1990-10-01 00:00:00

  • Topical naphazoline in the treatment of myasthenic blepharoptosis.

    abstract:INTRODUCTION:When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. METHODS:Sixty MG patients with blepharoptosis (32 ...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/mus.22002

    authors: Nagane Y,Utsugisawa K,Suzuki S,Masuda M,Shimizu Y,Utsumi H,Uchiyama S,Suzuki N

    更新日期:2011-07-01 00:00:00

  • Conduction and excitability properties of peripheral nerves in end-stage liver disease.

    abstract::The pathophysiology of hepatic neuropathy is poorly understood, but membrane depolarization due to a toxic inhibition of oxidative metabolism has been proposed. We investigated the relationship between nerve excitability properties, nerve dysfunction, and liver function in 11 pretransplant patients, the majority of wh...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20765

    authors: Ng K,Lin CS,Murray NM,Burroughs AK,Bostock H

    更新日期:2007-06-01 00:00:00

  • Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HAART).

    abstract::Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20338

    authors: Authier FJ,Chariot P,Gherardi RK

    更新日期:2005-09-01 00:00:00

  • Bifacial weakness with paresthesias: Serial nerve conduction studies indicate diffuse demyelinating neuropathy.

    abstract:INTRODUCTION:Bifacial weakness with paresthesias is a rare subtype of Guillain-Barré syndrome (GBS), characterized by facial diplegia in the absence of any other cranial neuropathies, limb weakness, or ataxia. Frequently, patients also complain of distal limb paresthesias before or at the time they develop facial weakn...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25028

    authors: Morgan C,Fuller G,Wakerley BR

    更新日期:2016-05-01 00:00:00

  • Adenosine inhibits depolarization-induced Ca(2+) release in mammalian skeletal muscle.

    abstract::In normal skeletal muscle, prolonged stimulation results in some cellular adenosine triphosphate (ATP) being converted to adenosine monophosphate (AMP) and then deaminated to inosine monophosphate (IMP). Here, we investigate whether the build-up of IMP contributes to muscle fatigue and also determine what happens if A...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199912)22:12<1674::aid-mus

    authors: Blazev R,Lamb GD

    更新日期:1999-12-01 00:00:00

  • Myonuclear domains in muscle adaptation and disease.

    abstract::Adult skeletal muscle fibers are among the few cell types that are truly multinucleated. Recently, evidence has accumulated supporting a role for the modulation of myonuclear number during muscle remodeling in response to injury, adaptation, and disease. These studies have demonstrated that muscle hypertrophy is assoc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(199910)22:10<1350::aid-mus

    authors: Allen DL,Roy RR,Edgerton VR

    更新日期:1999-10-01 00:00:00

  • Early diagnosis of n-hexane-caused neuropathy.

    abstract::n-Hexane neuropathy was studied in 20 workers exposed for prolonged periods to this solvent, and with urinary 2,5-hexanedione concentrations exceeding the biological exposure index recommended by the American Conference of Governmental Industrial Hygienists (5 mg/L) with a mean of 11.02 mg/L (range 5.3-24.2 mg/L). Alt...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170904

    authors: Pastore C,Marhuenda D,Marti J,Cardona A

    更新日期:1994-09-01 00:00:00

  • Molecular indicators of denervation in aging human skeletal muscle.

    abstract:INTRODUCTION:Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation. METHODS:Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Mess...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26638

    authors: Soendenbroe C,Heisterberg MF,Schjerling P,Karlsen A,Kjaer M,Andersen JL,Mackey AL

    更新日期:2019-10-01 00:00:00

  • Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice.

    abstract::Muscle fatigue occurs in many neuromuscular diseases, including the muscular dystrophies, and it contributes to a loss of functional capacity and reduced quality of life for affected patients. An improvement in fatigue resistance has been observed in diaphragm muscles of mdx mice following insulin-like growth factor-I...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20082

    authors: Gregorevic P,Plant DR,Lynch GS

    更新日期:2004-09-01 00:00:00

  • Two-dimensional and shear wave elastography ultrasound: A reliable method to analyse spastic muscles?

    abstract:INTRODUCTION:Few data exist on the feasibility and reliability of measuring muscular atrophy in 2 dimensions (2D) by ultrasonography (US) and elasticity with shear wave elastography (SWE) in spastic muscles. METHODS:Fourteen patients with chronic stroke took part in 2 intersession reliability experiments performed wit...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25716

    authors: Mathevon L,Michel F,Aubry S,Testa R,Lapole T,Arnaudeau LF,Fernandez B,Parratte B,Calmels P

    更新日期:2018-02-01 00:00:00

  • Emetine myopathy: two case reports with pathobiochemical analysis.

    abstract::We report two female patients with a history of alcohol abuse presenting with proximal painful muscle weakness following aversion therapy with emetine hydrochloride. Muscle biopsy of Case 1 showed a reversible floccular-shaped loss of myosin ATPase and dehydrogenase, an accumulation of PAS positive material, and a nor...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880070109

    authors: Sugie H,Russin R,Verity MA

    更新日期:1984-01-01 00:00:00

  • Location-dependent change of median nerve mobility in the carpal tunnel of patients with carpal tunnel syndrome.

    abstract:INTRODUCTION:The purpose of this study was to investigate in vivo median nerve longitudinal mobility in different segments of the carpal tunnel associated with active finger motion in carpal tunnel syndrome (CTS) patients in a comparison with healthy controls. METHODS:Eleven healthy volunteers and 11 CTS patients part...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.27017

    authors: Yao Y,Grandy E,Evans PJ,Seitz WH Jr,Li ZM

    更新日期:2020-10-01 00:00:00

  • KANDID--an EMG decision support system--evaluated in a European multicenter trial.

    abstract::KANDID is an advanced EMG decision support system dedicated to the support of the clinical neurophysiologist during EMG examinations. It has facilities for test planning, automatized and structured data interpretation, EMG diagnosis, explanation, and reporting. In a prospective European multicenter field trial, the ag...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/mus.880160514

    authors: Vingtoft S,Fuglsang-Frederiksen A,Rønager J,Petrera J,Stigsby B,Willison RG,Jarratt JA,Fawcett PR,Schofield IS,Otte G

    更新日期:1993-05-01 00:00:00

  • Origin of surface motor unit potentials in hypothenar motor unit number estimation.

    abstract:INTRODUCTION:Far-field potentials (FFPs) from muscles other than the abductor digiti minimi (ADM) may interfere with motor unit number estimation (MUNE) from that muscle. METHODS:We identified the origin of each surface motor unit potential (SMUP) during hypothenar MUNE using the multiple point stimulation method in 2...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23746

    authors: Kawamura Y,Sonoo M,Higashihara M,Chiba T,Hatanaka Y

    更新日期:2013-08-01 00:00:00

  • Effects of superimposed electrical stimulation on perceived discomfort and torque increment size and variability.

    abstract::Superimposed electrical stimulation techniques can be used to detect central activation failure (CAF), that is, incomplete central nervous system recruitment or suboptimal activation of motor units. The purpose of this study was to evaluate the effects of two stimulation parameters on perceived discomfort and torque i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10289

    authors: Miller M,Downham D,Lexell J

    更新日期:2003-01-01 00:00:00

  • Turns-amplitude analysis in normal and myopathic facial muscles.

    abstract::The purpose of this study was to assess turns/amplitude analysis (TAA) as an objective alternative to conventional qualitative electromyography (EMG) for detection of myopathy in facial muscles. Normal values of TAA parameters were calculated in the frontalis and mentalis muscles of 26 control subjects. We estimated t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21876

    authors: Karandreas N,Kararizou E,Papagianni A,Zambelis T,Kokotis P

    更新日期:2011-03-01 00:00:00

  • Comparison of distal sympathetic with vagal function in diabetic neuropathy.

    abstract::We measured distal sympathetic and vagal function in 73 consecutive patients with diabetic neuropathy seen at the Mayo Autonomic Reflex Laboratory. Postganglionic sympathetic failure measured proximally within the foot occurred as commonly as vagal failure (58% and 55%, respectively) and occurred much more frequently ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090703

    authors: Low PA,Zimmerman BR,Dyck PJ

    更新日期:1986-09-01 00:00:00

  • Changes in intramuscular collagen and fibronectin in denervation atrophy.

    abstract::The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880080208

    authors: Salonen V,Lehto M,Kalimo M,Penttinen R,Aro H

    更新日期:1985-02-01 00:00:00

  • Contribution of the Na(+)-K+ pump to membrane potential in familial periodic paralysis.

    abstract::The possibility has been raised that in familial periodic paralysis, the relatively large depolarization of the muscle fiber membrane seen during periods of paralysis might be attributable to a reduction in activity of the electrogenic Na(+)-K+ pump. The theoretical analysis presented here shows that although such hyp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880080503

    authors: Martin AR,Levinson SR

    更新日期:1985-06-01 00:00:00

  • Myasthenia gravis and premature ovarian failure.

    abstract::We describe a patient who developed seropositive myasthenia gravis 16 years after she was diagnosed with autoimmune premature ovarian failure with antibodies to the receptor for follicle-stimulating hormone (FSH). Although thymectomy led to improvement of her myasthenic symptoms, menses did not resume. Such combined s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20067

    authors: Ryan MM,Jones HR Jr

    更新日期:2004-08-01 00:00:00

  • Elucidation of muscle-binding peptides by phage display screening.

    abstract::Muscle makes up the largest tissue volume of the body, yet its size makes muscle-specific therapy difficult. This becomes particularly relevant when approaches to gene therapy for inherited myopathies are evaluated. Thus, a mechanism to target constructs or pharmaceuticals to muscle following intravenous injection wou...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199904)22:4<460::aid-mus6>

    authors: Samoylova TI,Smith BF

    更新日期:1999-04-01 00:00:00

  • Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability.

    abstract:INTRODUCTION:Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings. METHODS:We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24957

    authors: Leote J,Pereira P,Cabib C,Cipullo F,Valls-Sole J

    更新日期:2016-06-01 00:00:00

  • Myotonic Dystrophy Health Index: initial evaluation of a disease-specific outcome measure.

    abstract:INTRODUCTION:In preparation for clinical trials we examine the validity, reliability, and patient understanding of the Myotonic Dystrophy Health Index (MDHI). METHODS:Initially we partnered with 278 myotonic dystrophy type-1 (DM1) patients and identified the most relevant questions for the MDHI. Next, we used factor a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24097

    authors: Heatwole C,Bode R,Johnson N,Dekdebrun J,Dilek N,Heatwole M,Hilbert JE,Luebbe E,Martens W,Mcdermott MP,Rothrock N,Thornton C,Vickrey BG,Victorson D,Moxley R 3rd

    更新日期:2014-06-01 00:00:00

  • Activity of 2'3'-cyclic-nucleotide 3'-phosphodiesterase and content of PO protein in the peripheral nervous system of the dystrophic mouse and chicken.

    abstract::To investigate whether various myelin markers could detect pathological changes in myelination, the activity of 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and the level of PO protein were compared in the peripheral nervous system (PNS) of the dystrophic mouse and chicken and their phenotypically normal sibling...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880080207

    authors: Lewis LN,Mezei C

    更新日期:1985-02-01 00:00:00

  • Perioral reflexes in orofacial dyskinesia and spasmodic dysphonia.

    abstract::In order to assess the clinical utility of trigemino-facial reflexes in lower facial muscles, we studied perioral reflexes to mechanical and electrical stimulation in 13 patients with spasmodic dysphonia and orofacial dyskinesia and in 7 healthy subjects. Mechanical stimulation of the upper lip of all patients and ele...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880150906

    authors: Topka H,Hallett M

    更新日期:1992-09-01 00:00:00

  • Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS:We included 55 ALS pat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25682

    authors: Schreiber S,Debska-Vielhaber G,Abdulla S,Machts J,Schreiber F,Kropf S,KÖrtvelyessy P,KÖrner S,Kollewe K,Petri S,Dengler R,Kunz WS,Nestor PJ,Vielhaber S

    更新日期:2018-02-01 00:00:00