Abstract:
:Muscle makes up the largest tissue volume of the body, yet its size makes muscle-specific therapy difficult. This becomes particularly relevant when approaches to gene therapy for inherited myopathies are evaluated. Thus, a mechanism to target constructs or pharmaceuticals to muscle following intravenous injection would be advantageous. By screening a random phage display library we have identified a heptapeptide sequence, ASSLNIA, with enhanced in vivo skeletal and cardiac muscle binding. Phage carrying this peptide showed a 9- to 20-fold (depending on control tissue) increase in muscle selectivity compared with phage with no insert. When the injected individual phage clone was localized by immunohistochemistry, it was found within focal areas of the membrane of myofibers. Thus, the peptide identified represents a ligand that is capable of accessing skeletal and cardiac muscle from the lumen of blood vessels and could therefore readily be exploited for targeted delivery to muscle cells.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Samoylova TI,Smith BFdoi
10.1002/(sici)1097-4598(199904)22:4<460::aid-mus6>subject
Has Abstractpub_date
1999-04-01 00:00:00pages
460-6issue
4eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199904)22:4<460::AID-MUS6>journal_volume
22pub_type
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