Molecular indicators of denervation in aging human skeletal muscle.

Abstract:

INTRODUCTION:Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation. METHODS:Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Messenger RNA (mRNA) levels of acetylcholine receptors (AchR) were measured, and sections were stained for embryonic myosin, neonatal myosin (MHCn ), and neural cell adhesion molecule (NCAM). RESULTS:Embryonic myosin+ fibers were rare, while MHCn+ and NCAM+ fibers were observed in all samples. Age (range, 65-94 years) was negatively associated with AchRγ mRNA. DISCUSSION:Muscle from healthy older individuals expressed developmental myosins to varying degrees but more than has been previously reported for young individuals. Along with the AchR correlations, we propose that these findings support the presence of neuromuscular junction destabilization, denervation, and reinnervation in aging human skeletal muscle.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Soendenbroe C,Heisterberg MF,Schjerling P,Karlsen A,Kjaer M,Andersen JL,Mackey AL

doi

10.1002/mus.26638

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

453-463

issue

4

eissn

0148-639X

issn

1097-4598

journal_volume

60

pub_type

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