Abstract:
INTRODUCTION:Two previously reported Norwegian patients with painful muscle cramps and giant myotonic discharges were genotyped and compared with those of members of 21 families harboring the same mutation. METHODS:Using primers specific for SCN4A and CLCN1, the DNA of the Norwegian family members was amplified and bidirectionally sequenced. Clinical and neurophysiological features of other families harboring the same mutation were studied. RESULTS:A G1306A mutation in the Nav1.4 voltage-gated sodium channel of skeletal muscle was identified. This mutation is known to cause myotonia fluctuans. No giant myotonic discharges or painful muscle cramps were found in the other G1306A families. CONCLUSIONS:Ephaptic transmission between neighboring muscle fibers may not only cause the unusual size of the myotonic discharges in this family, but also a more severe type of potassium-aggravated myotonia than myotonia fluctuans.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Torbergsen T,Jurkat-Rott K,Stålberg EV,Løseth S,Hødneø A,Lehmann-Horn Fdoi
10.1002/mus.24672subject
Has Abstractpub_date
2015-10-01 00:00:00pages
680-3issue
4eissn
0148-639Xissn
1097-4598journal_volume
52pub_type
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