Abstract:
BACKGROUND:A higher total dose of radiation therapy administered in fractionated lower individual doses twice daily (hyperfractionated radiation therapy) has been reported to improve survival for children with brain stem gliomas. However, this higher dose of radiation therapy may cause more sequelae. METHOD:Eighty-eight children with brain stem gliomas were treated with 100 cGy twice daily to a total dose of 7200 cGy. Patients were carefully followed up for treatment-related clinical or radiographic worsening. RESULTS:Thirteen (15%) had intralesional cystic/necrotic changes within 8 weeks of completion of treatment. Children with these changes had a variable clinical course, including steady deterioration in one child; initial improvement, followed by progressive deterioration in three; and initial improvement, followed by deterioration, with subsequent improvement or prolonged stabilization of condition without additional antineoplastic treatment in nine. CONCLUSION:This latter "triphasic" course suggests that "early" worsening after hyperfractionated radiation therapy at 7200 cGy may be a sequelae of therapy, rather than a symptom of progressive tumor growth. This has substantial implications for patient care and evaluation of the efficacy of treatment.
journal_name
Cancerjournal_title
Cancerauthors
Packer RJ,Zimmerman RA,Kaplan A,Wara WM,Rorke LB,Selch M,Goldwein J,Allen JA,Boyett J,Albright ALdoi
10.1002/1097-0142(19930415)71:8<2666::aid-cncr2820subject
Has Abstract,Author List Incompletepub_date
1993-04-15 00:00:00pages
2666-74issue
8eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
临床试验,杂志文章,多中心研究相关文献
CANCER文献大全abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197811)42:5<2379::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::The objective of this study was to evaluate the sensitivity of two methods for determining bone marrow involvement with non-Hodgkin's lymphoma. These methods were histologic review of bone marrow aspirates, and clot sections versus in vitro growth of lymphoma colonies on soft agar. Forty-two bone marrow aspirates were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840415)53:8<1724::aid-cncr2820
更新日期:1984-04-15 00:00:00
abstract:BACKGROUND AND METHODS:Predictors of distant relapse following conservative surgery for breast cancer were studied in a review of 425 women. Five steps of breast cancer patient management were defined in which increasing amounts of information, potentially relevant to prognosis for metastasis-free survival (MFS), were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930815)72:4<1261::aid-cncr2820
更新日期:1993-08-15 00:00:00
abstract:BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acqu...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.11009
更新日期:2002-12-15 00:00:00
abstract::Non-Hodgkin's lymphoma confined to the liver is unusual in adults and has not been reported in children. Two children with primary hepatic and one with hepatosplenic NHL are described. All three patients are males, and both tumors examined for cell surface markers were of B-cell origin. Two patients, treated with chem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831215)52:12<2285::aid-cncr282
更新日期:1983-12-15 00:00:00
abstract:BACKGROUND:Recombinant tumor necrosis factor-alpha (rTNF-alpha) is a highly potential antineoplastic agent. However, its systemic administration in humans has resulted in a life-threatening septic shock-like syndrome, and its use has been abandoned. The administration of high dose rTNF-alpha and melphalan via isolated ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970315)79:6<1129::aid-cn
更新日期:1997-03-15 00:00:00
abstract::If women examine their breasts thoroughly and regularly they may promptly recognize abnormal tissue changes. The level of skill and motivation required for effective breast self-examination (BSE), however, is very high. In a prospective study of 304 patients with newly diagnosed breast cancer, 165 (54%) claimed to pra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860815)58:4<973::aid-cncr28205
更新日期:1986-08-15 00:00:00
abstract::Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:11<2505::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract::The establishment of a maturation-induction model using human colon cancer cells as targets is reported. Two colon carcinoma cell lines were established from human tumors; one line was heterogeneous and was cloned into two distant subpopulations. Cells from these lines and clones and cells from an established human co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:5+<1178::aid-cncr282
更新日期:1980-03-15 00:00:00
abstract::The clinical, morphologic, and immunohistochemical features of 5 cases of peripheral T-cell lymphoma with lymph node and skin involvement are reported. All patients were male and presented with generalized lymphadenopathy and skin lesions. Lymph node biopsy specimens showed a diffusely growing, pleomorphic, atypical l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1714::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract:BACKGROUND:There are three distinct types of doxorubicin-induced cardiotoxicity (acute, chronic, and late-onset). Although previous studies with animal models suggest that angiotensin II plays a key role in the process of the doxorubicin-induced cardiotoxicity, there has been no such observation in humans. This randomi...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.21478
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents. METHODS:Tumor response was evaluated by usin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24009
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Clinical practice guidelines for the management of breast carcinoma were introduced in Australia in October, 1995. This article describes the management of early-stage breast carcinoma both before and after the introduction of these guidelines. METHODS:All cases of early breast carcinoma that were diagnosed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20401
更新日期:2004-08-01 00:00:00
abstract::The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<354::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract:BACKGROUND:A sedentary life style has been consistently associated with an increased risk of colon cancer, but the evidence for its association with breast and other gynecologic cancers is limited. METHODS:Occupational information for 3783 incident patients with cancer (breast, 2736; corpus uteri, 452; and ovary, 595)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3620::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28659
更新日期:2014-06-15 00:00:00
abstract:BACKGROUND:Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-po...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30512
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:This study sought to investigate biological/clinicopathological characteristics of neuroblastoma, undifferentiated subtype (NBUD). METHODS:This study examined 157 NBUD cases filed at the Children's Oncology Group Neuroblastoma Pathology Reference Laboratory, and survival rates of the patients were analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28251
更新日期:2013-10-15 00:00:00
abstract::A case of osteosarcoma arising in the soft tissue of the larynx in an elderly man is presented with light and electron microscopic documentation. The patient developed chronic hoarseness and a recurring polypoid laryngeal tumor, causing acute airway obstruction. He was treated by total laryngectomy, but he died with m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197811)42:5<2343::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1334::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:Testicular cancer is curable in the majority of men, and persisting treatment toxicity is a concern. The authors report a cross-sectional study of the long-term effects of chemotherapy (C) on neurologic function and development of Raynaud phenomenon. METHODS:Seven hundred thirty-nine patients who were treat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24981
更新日期:2010-05-15 00:00:00
abstract::Few studies have incorporated high-dose methotrexate (MTX) with leucovorin rescue in the treatment of small cell lung cancer (SCLC). Potentially therapeutic levels of MTX can be achieved in the central nervous system (CNS) by systemic administration of high doses of this drug. Utilizing a combination chemotherapy prog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1056::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract:BACKGROUND:Studies evaluating the efficacy of routine follow-up testing in detecting disease recurrence in treated lung carcinoma patients are lacking. METHODS:To investigate this subject, the authors studied 115 patients who had previously been entered on North Central Cancer Treatment Group (NCCTG) small cell lung c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-08-15 00:00:00
abstract::Epithelioid sarcoma is an uncommon tumor characterized by its appearance in the distal extremities (especially the forearm, wrist, and ankle), the tendency to recur locally, and high probability of spread to regional lymph nodes. Most patients have been treated surgically, and the potential role of radiation therapy a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<1022::aid-cncr2820
更新日期:1983-09-15 00:00:00
abstract::The role of 99mTc-pertechnetate thyroid imaging in the preoperative assessment of patients with single palpable thyroid nodules was evaluated. The frequency of cancer in hypofunctional nodules was similar to that found in previous studies with 131I. The 99mTc-pertechnetate image allowed a reliable separation of pathol...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1<258::aid-cncr2820370
更新日期:1976-01-01 00:00:00
abstract::Six patients with lymphomatoid granulomatosis were studied. Two patients had eye involvement, a rare manifestation of this disease. Both had complete disappearance of disease in this area after radiation therapy. One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy. Th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2070::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31873
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:This study analyzed whether proliferative activity and expression of P-glycoprotein 170 (P-170) or glutathione S-transferase-pi (GST-pi) in human non-small cell lung carcinomas (NSCLC) represent independent factors in resistance to doxorubicin or whether an association exists between these factors. METHODS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920815)70:4<764::aid-cncr28207
更新日期:1992-08-15 00:00:00
abstract:BACKGROUND:Pericolorectal tumor deposits (TDs) are associated with adverse outcomes in patients with colorectal cancer, and the seventh edition of the American Joint Committee on Cancer (AJCC) staging system recently classified TDs without regional lymph node metastasis as category N1c. However, the definition of TDs h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25968
更新日期:2011-09-01 00:00:00
abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044
更新日期:1979-12-01 00:00:00