Abstract：
:We have conducted a systematic evaluation of the calculated molecular properties of compounds in clinical development and have found that the development process selects for compounds that have certain computed physical properties. In particular, as the stage of development progresses, compounds that are advanced have lower calculated octanollwater partition coefficient (ClogP), polar surface area, and molecular weight. The findings of this study provide guidance for combinatorial library design and lead selection, which may enhance the chance for ultimate success in lead optimization.
journal_name
Biotechniquesjournal_title
BioTechniquesauthors
Blake JFsubject
Has Abstractpub_date
2003-06-01 00:00:00pages
16-20eissn
0736-6205issn
1940-9818journal_volume
Supplpub_type
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