Abstract:
:Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immunogenic serotypes were less frequently acquired and were carried for shorter periods, but no relationship between immunogenicity and invasiveness was apparent using either index of invasiveness. Frequent invasion was associated with a high acquisition rate and high frequency and prolonged duration of carriage. Carriage studies can provide a broad indication of which serotypes cause invasive disease but not the proportion of disease due to individual serotypes; some serotypes which cause invasive disease (e.g. serotype 46) are not found even in extensive carriage studies. The antibiotic resistance of carriage organisms, however, does approximate the resistance patterns of invasive organisms and thus may be used to monitor changing patterns of antimicrobial susceptibility in the community.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Smith T,Lehmann D,Montgomery J,Gratten M,Riley ID,Alpers MPdoi
10.1017/s0950268800056648subject
Has Abstractpub_date
1993-08-01 00:00:00pages
27-39issue
1eissn
0950-2688issn
1469-4409journal_volume
111pub_type
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