Abstract：
:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip injection, week 0), N-methyl-N-nitrosourea (MNU, 4 20-mg/kg ip injections, weeks 0-2), N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN, 0.05% in drinking water, weeks 0-2), N,N'-dimethylhydrazine (DMH, 4 40-mg/kg sc injections, weeks 2-4), and dihydroxy-di-N-propylnitrosamine (DHPN, 0.1% in drinking water, weeks 2-4) during the first 4 wk. In Groups 2-6, rats were treated with only one of the above initiators, applied as in Group 1. Group 7 served as the no-treatment control. Bromouracil deoxyriboside (BUdR) labeling indices (LI) were counted in various organs at weeks 2 and 4. Numbers and areas of glutathione S-transferase placental form positive (GST-P+) liver foci were measured at weeks 2, 4, and 28. Preneoplastic or neoplastic lesion development was assessed at week 28. With regard to specific elevation of cell proliferation in target organs, BUdR LIs in the urinary bladder, liver, and colon were, respectively, increased in the BBN alone, DEN alone, and DMH alone treated groups as well as in Group 1. However, LIs of thyroid, lung, and kidney were also elevated by several carcinogens not including these organs in their carcinogenic target specificity. On the other hand, morphological lesions and GST-P+ foci were limited to Group 1 and the target organs of the corresponding carcinogen-treated groups.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito Ndoi
10.1177/019262339302100502subject
Has Abstractpub_date
1993-09-01 00:00:00pages
436-42issue
5eissn
0192-6233issn
1533-1601journal_volume
21pub_type
杂志文章abstract：:A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse study data for 10 pharmaceutical candidates. These results were compar...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313477257
更新日期：2013-01-01 00:00:00
abstract：:The toxicity of polybrominated diphenyl ethers (PBDEs), flame-retardant components, was characterized in offspring from Wistar Han dams exposed by gavage to a PBDE mixture (DE71) starting at gestation day 6 and continuing to weaning on postnatal day (PND) 21. Offspring from the dams underwent PBDE direct dosing by gav...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311429973
更新日期：2012-01-01 00:00:00
abstract：:Documentation of Chinese materia medica (CMM) dates back to around 1,100 BC when only dozens of drugs were first described. By the end of the 16th century, the number of drugs documented had reached close to 1,900. And by the end of the last century, published records of CMM have reached 12,800 drugs. The recorded tra...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230600773958
更新日期：2006-01-01 00:00:00
abstract：:The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338901700308
更新日期：1989-01-01 00:00:00
abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600517
更新日期：1998-09-01 00:00:00
abstract：:To characterize the hepatic lesions in Fischer 344 (F344) rats afflicted with large granular lymphocyte (LGL) leukemia, the livers of rats with LGL leukemia at various stages were examined histopathologically and immunohistochemically. The morphologic features in the livers of rats afflicted with LGL leukemia were dif...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315578719
更新日期：2015-08-01 00:00:00
abstract：:GJA1 gene (Connexin43, also known as Cx43) is the most abundant gap junction protein isoform in animal cells and is associated with bone development in embryos. The objective of the present work was to evaluate in vivo osteal development in GJA1-deficient fetal mice through determination of the histological and molecu...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311422075
更新日期：2011-12-01 00:00:00
abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339702500615
更新日期：1997-11-01 00:00:00
abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...
journal_title：Toxicologic pathology
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更新日期：2007-04-01 00:00:00
abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317749469
更新日期：2018-02-01 00:00:00
abstract：:The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolati...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623316675765
更新日期：2017-01-01 00:00:00
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journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623310390231
更新日期：2011-01-01 00:00:00
abstract：:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powde...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312470763
更新日期：2013-08-01 00:00:00
abstract：:Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological m...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318767065
更新日期：2018-04-01 00:00:00
abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338901700109
更新日期：1989-01-01 00:00:00
abstract：:The fate of inspired mercury vapour (Hg0) is critical in the central nervous system (CNS) where it can circumvent the blood-brain barrier (BBB) at the neuromuscular junction (NMJ) and accumulate indefinitely in motor neurons by retrograde transport. The detoxification of systemic Hg0 by lung and liver requires investi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230390226069
更新日期：2003-09-01 00:00:00
abstract：:Oxidant generation catalyzed by metals has been postulated to account for a lung injury following exposure to air pollution particles. In particles that are predominantly carbonaceous, it is difficult to implicate such an oxidative stress as the responsible mechanism, since concentrations of metals can be extremely lo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800416
更新日期：2000-07-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2017-07-01 00:00:00
abstract：:Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different stages of s...
journal_title：Toxicologic pathology
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更新日期：2014-12-01 00:00:00
abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...
journal_title：Toxicologic pathology
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更新日期：1986-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2014-07-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2011-06-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：1992-01-01 00:00:00
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journal_title：Toxicologic pathology
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更新日期：2010-02-01 00:00:00
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abstract：:The prevalence of liver and skin tumors in brown bullhead ( Ameiurus nebulosus) from the Anacostia River (Washington, DC) and nearby areas was determined in 2014, 2015, and 2016. The objectives were to (1) compare tumor prevalence across space and time; (2) analyze the 1992-2016 Chesapeake Bay Tumor Database to identi...
journal_title：Toxicologic pathology
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更新日期：2019-02-01 00:00:00
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