Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition.

abstract：:There has been a substantial increase in the number and efficacy of laboratory biomarkers for the evaluation of human cardiac injury over the last decade. The advantages of these over traditional laboratory tests have encouraged adoption of comparable markers in nonclinical studies for cardiac injury assessment. Of pa...

journal_title：Toxicologic pathology

authors： Walker DB

更新日期：2006-01-01 00:00:00

abstract：:Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 w...

journal_title：Toxicologic pathology

authors： Gray RH,Adam-Rodwell GA,Maris D,Haskins JR,Stoner GD

更新日期：1995-11-01 00:00:00

abstract：:The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and biochemistry of minipigs are similar enough to humans to consider them as ...

journal_title：Toxicologic pathology

authors： Colleton C,Brewster D,Chester A,Clarke DO,Heining P,Olaharski A,Graziano M

更新日期：2016-04-01 00:00:00

abstract：:Laser scanning cytometry (LSC) is a powerful tool for qualitative and quantitative analysis of tissue sections in preclinical drug development. LSC combines the strengths of flow cytometry with tissue architecture retention. This technology has been used predominantly with immunofluorescent techniques on cell culture ...

journal_title：Toxicologic pathology

authors： Peterson RA,Krull DL,Butler L

更新日期：2008-01-01 00:00:00

abstract：:Chronic (24-month) inhalation exposure to 5 or 10 ppm allyl glycidyl ether (AGE) induced nasal lesions in Osborne-Mendel rats and B6C3F1 mice. Inflammation, degeneration, regeneration, metaplasia, hyperplasia, and neoplasia were observed in the nasal mucosa. Squamous metaplasia and hyperplasia of the respiratory epith...

journal_title：Toxicologic pathology

authors： Renne RA,Brown HR,Jokinen MP

更新日期：1992-01-01 00:00:00

abstract：:Histopathologic examination of the testis from juvenile rats is often necessary to characterize the safety of new drugs for pediatric use and is a required end point in male pubertal development and thyroid function assays. To aid in evaluation and interpretation of the immature testis, the characteristic histologic f...

journal_title：Toxicologic pathology

authors： Picut CA,Remick AK,de Rijk EP,Simons ML,Stump DG,Parker GA

更新日期：2015-04-01 00:00:00

abstract：:Recommendations (best practices) are provided by the Society of Toxicologic Pathology's Adversity Working Group for making consistent interpretations of test article-related effects as "adverse" and assigning a "no observed adverse effect level" (NOAEL) in nonclinical toxicity studies. Adverse is a term indicating "ha...

journal_title：Toxicologic pathology

authors： Kerlin R,Bolon B,Burkhardt J,Francke S,Greaves P,Meador V,Popp J

更新日期：2016-02-01 00:00:00

abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...

journal_title：Toxicologic pathology

authors： Stoll RE,Holden HE,Barthel CH,Blanchard KT

更新日期：1999-09-01 00:00:00

abstract：:In organs with diverse cell populations, it is not uncommon for one type of cell to respond while others are spared. Even in an organ with common cell types, such as hepatocytes within the liver, the population of cells may respond with different sensitivities for injury or for biochemical responses to toxicants. In t...

journal_title：Toxicologic pathology

authors： Andersen ME

更新日期：2002-01-01 00:00:00

abstract：:Previous work in our laboratory revealed that the pubertal period of reproductive development in the male rat was particularly vulnerable to gossypol exposure, with a higher frequency of round structures in the lumen of the cauda epididymidis in the treated rats. Herein, we utilized hemicastration and electron microsc...

journal_title：Toxicologic pathology

authors： de Andrade SF,Oliva SU,Klinefelter GR,De Grava Kempinas W

更新日期：2006-01-01 00:00:00

abstract：:ISIS 2302 is a phosphorothioate oligodeoxynucleotide with a sequence complementary to the mRNA of human intercellular adhesion molecule 1 (ICAM-1). Hybridization of ISIS 2302 to the mRNA inhibits expression of the ICAM-1 protein in response to inflammatory stimuli. A murine active antisense oligonucleotide, ISIS 3082,...

journal_title：Toxicologic pathology

authors： Henry SP,Templin MV,Gillett N,Rojko J,Levin AA

更新日期：1999-01-01 00:00:00

abstract：:Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...

journal_title：Toxicologic pathology

authors： Parkinson A

更新日期：1996-01-01 00:00:00

abstract：:Expression of antigens in cells and tissues can be readily studied immunohistochemically with the use of antibodies. A panel of antibodies to cell-specific markers can be used to diagnose lesions, including tumors, in the hematopoietic and lymphoid systems. This review discusses the use of readily available antibodies...

journal_title：Toxicologic pathology

authors： Rehg JE,Bush D,Ward JM

更新日期：2012-01-01 00:00:00

abstract：:In carcinogenicity studies with PPAR gamma and alpha/gamma agonists, urinary bladder tumors have been reported in Harlan Sprague-Dawley (HSD) and Charles River Sprague-Dawley (SD) but not Wistar (WI) rats, with urolithiasis purported to be the inciting event. In two 3-month studies, the authors investigated strain-rel...

journal_title：Toxicologic pathology

authors： Tannehill-Gregg SH,Dominick MA,Reisinger AJ,Moehlenkamp JD,Waites CR,Stock DA,Sanderson TP,Cohen SM,Arnold LL,Schilling BE

更新日期：2009-04-01 00:00:00

abstract：:To characterize the promoting activity of thiobenzamide (TB), a thiono-sulfur-containing xenobiotic, rats of both sexes were treated with the compound for 4 or 8 weeks after an initiating dose of diethyl-nitrosamine. The number, area (volume), and phenotypic complexity of the enzyme-altered hepatocyte foci were studie...

journal_title：Toxicologic pathology

authors： Malvaldi G,Chieli E,Saviozzi M

更新日期：1986-01-01 00:00:00

abstract：:This brief review summarizes our current understanding of vasculitis mediated by phlogistic immune complexes. The Arthus reaction and serum sickness both represent experimental models for immune complex disease. Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infe...

journal_title：Toxicologic pathology

authors： Krakowka S

更新日期：1989-01-01 00:00:00

abstract：:Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

journal_title：Toxicologic pathology

authors： Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

更新日期：2012-10-01 00:00:00

abstract：:Clinically, girls appear to be more sensitive than boys to the cardiotoxic effects of doxorubicin, whereas the opposite may be true for adults. To identify and characterize potential sex-related differences, adult male and female spontaneously hypertensive rats (SHR; some ovariectomized [OVX]) received 1 mg/kg of doxo...

journal_title：Toxicologic pathology

authors： Zhang J,Knapton A,Lipshultz SE,Cochran TR,Hiraragi H,Herman EH

更新日期：2014-01-01 00:00:00

abstract：:The 2019 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology's 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This ar...

journal_title：Toxicologic pathology

authors： Elmore SA,Cesta MF,Crabbs TA,Janardhan KS,Krane GA,Mahapatra D,Quist EM,Rinke M,Schaaf GW,Travlos GS,Wang H,Willson CJ,Wolf JC

更新日期：2019-12-01 00:00:00

abstract：:Dysfunction of the visual system remains a leading cause of human disability worldwide. Preclinical studies are a key component of efforts to develop drugs and devices to ameliorate visual impairment. Although new opportunities for the delivery of targeted ocular therapeutics have been created, clinical success has be...

journal_title：Toxicologic pathology

authors： Ramos MF,Schafer KA,Sorden SD

更新日期：2021-01-05 00:00:00

abstract：:During the conduct of in vivo toxicology studies, in-life, clinical pathology, and anatomic pathology parameters are collected and interpreted. These sets of parameters are evaluated in an integrative manner to determine the overall toxicity of a test article. For clinical pathology parameters, the inherent variabilit...

journal_title：Toxicologic pathology

authors： Everds NE

更新日期：2015-01-01 00:00:00

abstract：:The 2012 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Boston in advance of the Society of Toxicologic Pathology's 31st annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic patholog...

journal_title：Toxicologic pathology

authors： Elmore SA,Berridge BR,Boyle MC,Cora MC,Hoenerhoff MJ,Kooistra L,Laast VA,Morrison JP,Rao D,Rinke M,Yoshizawa K

更新日期：2013-02-01 00:00:00

abstract：:Epidemiological associations have been made between the new onset of childhood rhinitis/asthma and exposures to elevated ambient levels of ozone, a commonly encountered gaseous air pollutant. Our laboratory was the first to find that mice repeatedly exposed to ozone develop nasal type 2 immunity and eosinophilic rhini...

journal_title：Toxicologic pathology

authors： Harkema JR,Wagner JG

更新日期：2019-12-01 00:00:00

abstract：:One application of genomics in drug safety assessment is the identification of biomarkers to predict compound toxicity before it is detected using traditional approaches, such as histopathology. However, many genomic approaches have failed to demonstrate superiority to traditional methods, have not been appropriately ...

journal_title：Toxicologic pathology

authors： Fielden MR,Eynon BP,Natsoulis G,Jarnagin K,Banas D,Kolaja KL

更新日期：2005-01-01 00:00:00

abstract：:Chronic prostatitis characterized on light microscopic examination by moderate, multifocal, predominantly lymphocytic inflammation associated with epithelial atypia and intranuclear and cytoplasmic inclusion-like material was identified in the prostate gland of 2 Wistar Han rats administered an immunomodulatory test a...

journal_title：Toxicologic pathology

authors： Masek-Hammerman K,Brown TP,Bobrowski WF,Tomlinson L,Debrue M,Whiteley L,Radi Z

更新日期：2017-07-01 00:00:00

abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...

journal_title：Toxicologic pathology

authors： Long AJ,Sampson E,McCarthy RW,Harris CM,Barnard M,Shi D,Conlon D,Caldwell R,Honor D,Wishart N,Hoemann M,Duggan L,Fritz D,Stedman C,O'Connor E,Mikaelian I,Schwartz A

更新日期：2016-10-01 00:00:00

abstract：:After 15 years of existence, the ACVP/STP Coalition for Veterinary Pathology Fellows will dissolve, primarily due to lack of renewed financial sponsorship. While in operation, the Coalition organized 32 new training position for veterinary pathologists, supported by $7.4 M from sponsors, including pharmaceutical and b...

journal_title：Toxicologic pathology

authors： Adler R,Clark E,Cline M,Conner M,Crabbs T,Fossey S,Malarkey D,Meseck E,Vernau W,Tornquist S,McDorman K,Rees S,Cockerell G

更新日期：2020-06-01 00:00:00

abstract：:Alloxan-induced diabetic rats frequently exhibit proliferative lesions of squamous hyperplasia accompanied by chronic inflammation and Candida albicans infection in the forestomach, and some lesions progress to squamous cell carcinoma (SCC). Candida infection causes not only hyperplastic changes with inflammation but ...

journal_title：Toxicologic pathology

authors： Sano T,Ozaki K,Kodama Y,Matsuura T,Narama I

更新日期：2009-10-01 00:00:00

abstract：:We conducted a retrospective analysis of publicly available preclinical toxicology studies with erythropoiesis-stimulating agents (ESAs) to examine common adverse events in rats, Beagle dogs, and cynomolgus monkeys. Mortality and/or thrombotic events were reported sporadically in a subset of studies and attributed to ...

journal_title：Toxicologic pathology

authors： Andrews DA,Pyrah IT,Boren BM,Tannehill-Gregg SH,Lightfoot-Dunn RM

更新日期：2014-01-01 00:00:00

abstract：:Aroclor 1254, at a dose level of 280 micrograms/kg body weight equivalent to 200 micrograms/kg/day, was given 5 days per week to rhesus monkeys over a 27 to 28 month period. Terminal clinical signs of varying severity included fingernail detachment, exuberant nail beds, weight loss, stomatitis and normocytic anemia. A...

journal_title：Toxicologic pathology

authors： Tryphonas L,Arnold DL,Zawidzka Z,Mes J,Charbonneau S,Wong J

更新日期：1986-01-01 00:00:00