A pilot study in adult rhesus monkeys (M. mulatta) treated with Aroclor 1254 for two years.

abstract：:The toxic effects of a mixture of 2-aminoanthracene (2-AA), benzanthracene (BA), and dinitropyrene isomers (DNP), and the toxic effects of these compounds individually, were investigated in the Fischer-344 rat following dietary exposure via a powdered basal diet. Animals were sacrificed at 14-, 30-, and 80-days of die...

journal_title：Toxicologic pathology

authors： Boudreau MD,Baker DG,Taylor HW,Barker SA,Means JC

更新日期：2001-05-01 00:00:00

abstract：:Transgenic Tg.AC mice carry a v-Ha-ras coding region flanked by a zeta-globin promoter and an SV40 polyadenylation signal sequence. These mice respond to carcinogens by developing epidermal papillomas. In some cases, malignancies develop at the sites of these papillomas. Various patterns of squamous cell differentiati...

journal_title：Toxicologic pathology

authors： Asano S,Trempus CS,Spalding JW,Tennant RW,Battalora MS

更新日期：1998-07-01 00:00:00

abstract：:Toxicokinetic (TK) studies are the basis for demonstrating dose-related drug exposure in animals and for ensuring that drug exposure is substantially greater in animals than that expected in humans at therapeutic doses. The usefulness of TK studies can be further enhanced by correlating TK parameters with relevant tox...

journal_title：Toxicologic pathology

authors： Batra VK

更新日期：1995-03-01 00:00:00

abstract：:To characterize the hepatic lesions in Fischer 344 (F344) rats afflicted with large granular lymphocyte (LGL) leukemia, the livers of rats with LGL leukemia at various stages were examined histopathologically and immunohistochemically. The morphologic features in the livers of rats afflicted with LGL leukemia were dif...

journal_title：Toxicologic pathology

authors： Shiga A,Narama I

更新日期：2015-08-01 00:00:00

abstract：:The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to p...

journal_title：Toxicologic pathology

authors： Elmore SA,Farman CA,Hailey JR,Kovi RC,Malarkey DE,Morrison JP,Neel J,Pesavento PA,Porter BF,Szabo KA,Teixeira LB,Quist EM

更新日期：2016-06-01 00:00:00

abstract：:An annular, reddened lesion with mild serosal hemorrhage and no tumorous mass formation was detected in the right uterine horn of a 37-week-old female Sprague-Dawley rat that had postpubertal vaginal bleeding. Histological examination revealed prominent proliferation of the endometrium, which occupied the uterine lume...

journal_title：Toxicologic pathology

authors： Shirota M,Kawashima J,Nakamura T,Ogawa Y,Kamiie J,Shirota K

更新日期：2013-01-01 00:00:00

abstract：:Absorbable metallic implants have been under investigation for more than a century. Animal and human studies have shown that magnesium (Mg) alloys can be safely used in bioresorbable scaffolds. Several cardiovascular and orthopedic biodegradable metallic devices have recently been approved for use in humans. Bioresorb...

journal_title：Toxicologic pathology

authors： Chagnon M,Guy LG,Jackson N

更新日期：2019-04-01 00:00:00

abstract：:The performance of the p53-/- transgenic (knockout) mouse model was evaluated through review of the data from 31 short-term carcinogenicity studies with 21 compounds tested as part of the International Life Sciences Institute's (ILSI) Alternatives to Carcinogenicity Testing (ACT) project, together with data from other...

journal_title：Toxicologic pathology

authors： Storer RD,French JE,Haseman J,Hajian G,LeGrand EK,Long GG,Mixson LA,Ochoa R,Sagartz JE,Soper KA

更新日期：2001-01-01 00:00:00

abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...

journal_title：Toxicologic pathology

authors： Payne SR,Kemp CJ

更新日期：2003-07-01 00:00:00

abstract：:Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons they may be conducted without a pathologist present at necropsy. Howev...

journal_title：Toxicologic pathology

authors： Nikula KJ,Funk K

更新日期：2016-01-01 00:00:00

abstract：:BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1, has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, and histologic lesions of i...

journal_title：Toxicologic pathology

authors： Fletcher AM,Bregman CL,Woicke J,Salcedo TW,Zidell RH,Janke HE,Fang H,Janusz WJ,Schulze GE,Mense MG

更新日期：2010-02-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:The use of biodegradable materials is gaining popularity in medicine, especially in orthopedic applications. However, preclinical evaluation of biodegradable materials can be challenging, since they are located in close contact with host tissues and might be implanted for a long period of time. Evaluation of these com...

journal_title：Toxicologic pathology

authors： Ramot Y,Nyska A,Markovitz E,Dekel A,Klaiman G,Zada MH,Domb AJ,Maronpot RR

更新日期：2015-12-01 00:00:00

abstract：:During preclinical investigations into the safety of drugs and chemicals, many are found to interfere with reproductive function in the female rat. This interference is commonly expressed as a change in normal morphology of the reproductive tract or a disturbance in the duration of particular phases of the estrous cyc...

journal_title：Toxicologic pathology

authors： Westwood FR

更新日期：2008-04-01 00:00:00

abstract：:Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we...

journal_title：Toxicologic pathology

authors： Calvisi DF,Thorgeirsson SS

更新日期：2005-01-01 00:00:00

abstract：:This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

journal_title：Toxicologic pathology

authors： Getz GS

更新日期：1990-01-01 00:00:00

abstract：:Nephrotoxic renal injury, and especially drug nephrotoxicity is now a common cause of acute renal failure. The most common patterns of renal injury produced by nephrotoxins, tubular damage, and interstitial nephritis, are discussed here. Toxic agents which are primarily tubular toxins include certain antibiotics, cisp...

journal_title：Toxicologic pathology

authors： Racusen LC,Solez K

更新日期：1986-01-01 00:00:00

abstract：:We examined the localization and expression of the nuclear oncoprotein c-myc and the cytoplasmic membrane-associated oncoprotein c-ras in rainbow trout cell lines derived from both normal and tumor tissue in order to question whether c-myc and ras oncoprotein immunostaining was increased in cells derived from tumors c...

journal_title：Toxicologic pathology

authors： Carter CA,Ellington WW,Van Beneden RJ

更新日期：1996-05-01 00:00:00

abstract：:A number of factors related to study design have the potential to impact clinical pathology test results during the conduct of nonclinical safety studies. A thorough understanding of these factors is paramount in drawing accurate conclusions from clinical pathology data generated during such studies, particularly when...

journal_title：Toxicologic pathology

authors： Aulbach A,Provencher A,Tripathi N

更新日期：2017-02-01 00:00:00

abstract：:The toxicity of polybrominated diphenyl ethers (PBDEs), flame-retardant components, was characterized in offspring from Wistar Han dams exposed by gavage to a PBDE mixture (DE71) starting at gestation day 6 and continuing to weaning on postnatal day (PND) 21. Offspring from the dams underwent PBDE direct dosing by gav...

journal_title：Toxicologic pathology

authors： Dunnick JK,Brix A,Cunny H,Vallant M,Shockley KR

更新日期：2012-01-01 00:00:00

abstract：:One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to de...

journal_title：Toxicologic pathology

authors： Miller RT,Davis BJ

更新日期：2001-01-01 00:00:00

abstract：:Many new observations have been made correlating changes in renal morphology with changes in renal function. These changes have led to a better definition of the various segments which make up the renal tubule. These morphological patterns vary in different species as is documented by morphologic studies and by differ...

journal_title：Toxicologic pathology

authors： Bulger RE

更新日期：1986-01-01 00:00:00

abstract：:Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F1 mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The most frequently occurring neoplasms in untreated male F344 rats were testicular adenoma (89.1%), mononuclear cell leukemia (5...

journal_title：Toxicologic pathology

authors： Haseman JK,Hailey JR,Morris RW

更新日期：1998-05-01 00:00:00

abstract：:(+/-)-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) and 9-hydroxybenzo(a)pyrene (9-OH-BP) were metabolized by rat liver microsomes in the presence of calf thymus DNA, resulting in preferential DNA binding of fluorescent (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) and 9-OH-BP-4,5-epoxide, respectively. When the ...

journal_title：Toxicologic pathology

authors： Gräslund A,Jernström B,Undeman O,Dock L,Ehrenberg A,Astlind T

更新日期：1984-01-01 00:00:00

abstract：:Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...

journal_title：Toxicologic pathology

authors： Esvelt MA,Freeman ZT,Pearson AT,Harkema JR,Clines GT,Clines KL,Dyson MC,Hoenerhoff MJ

更新日期：2019-02-01 00:00:00

abstract：:Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human h...

journal_title：Toxicologic pathology

authors： Gill S,Veinot J,Kavanagh M,Pulido O

更新日期：2007-04-01 00:00:00

abstract：:The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...

journal_title：Toxicologic pathology

authors： Morton D,Reed L,Huang W,Marcek JM,Austin-LaFrance R,Northcott CA,Schelling SH,Enerson BE,Tomlinson L

更新日期：2015-06-01 00:00:00

abstract：:The 2012 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Boston in advance of the Society of Toxicologic Pathology's 31st annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic patholog...

journal_title：Toxicologic pathology

authors： Elmore SA,Berridge BR,Boyle MC,Cora MC,Hoenerhoff MJ,Kooistra L,Laast VA,Morrison JP,Rao D,Rinke M,Yoshizawa K

更新日期：2013-02-01 00:00:00

abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...

journal_title：Toxicologic pathology

authors： Downes N,Mullins P

更新日期：2014-07-01 00:00:00

abstract：:Nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. Our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. We nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- SEM ages: 149 +/- 13 days) before and after in...

journal_title：Toxicologic pathology

authors： Anderson KA,Lemen RJ,Weger NS,Chen H,Bowers MC,Witten ML,Lantz RC,Bice DE,Muggenburg BA

更新日期：2000-03-01 00:00:00