Abstract:
:Necropsies conducted to support medical device development may be conducted in facilities that do not have the infrastructure in place to support Good Laboratory Practice for Nonclinical Laboratory Studies (GLP) studies and for a variety of reasons they may be conducted without a pathologist present at necropsy. However, when a novel medical device or one that is expected to significantly alter tissues is deployed, or when the surgical model confounds interpretation of device effects, it is the opinion of the authors that an experienced pathologist should be present at necropsy.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Nikula KJ,Funk Kdoi
10.1177/0192623315617035subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9-11issue
1eissn
0192-6233issn
1533-1601pii
0192623315617035journal_volume
44pub_type
杂志文章abstract::Highly standardized and controlled inhalation studies are required for hazard identification to make test results reproducible and comparable and to fulfill general regulatory requirements for the registration of new drugs, pesticides, or chemicals. Despite significant efforts, the results of inhalation studies have t...
journal_title:Toxicologic pathology
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journal_title:Toxicologic pathology
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abstract::Seventeen mesotheliomas from 395 untreated male Fischer 344/DuCrj rats were studied by light and electron microscopy to define the morphological characteristics of the tumors. In 16 out of 17 rats, mesotheliomas were observed in the abdominal and/or scrotal sac, and the other one was localized on the pleura. Grossly, ...
journal_title:Toxicologic pathology
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journal_title:Toxicologic pathology
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