Abstract:
:One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to determine their relevance to human health effects. The challenge is to train pathologists for toxicologic and molecular pathology experience without diluting basic pathology skills. Programs and approaches reviewed and suggested during the panel discussion should provide ideas and the impetus for those in a position to engage in similar activities.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Miller RT,Davis BJdoi
10.1080/019262301301418973subject
Has Abstractpub_date
2001-01-01 00:00:00pages
156-7issue
1eissn
0192-6233issn
1533-1601journal_volume
29pub_type
杂志文章abstract::Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...
journal_title:Toxicologic pathology
pub_type: 评论,杂志文章
doi:10.1177/019262339902700503
更新日期:1999-09-01 00:00:00
abstract::The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262330002800117
更新日期:2000-01-01 00:00:00
abstract::The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolati...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623316675765
更新日期:2017-01-01 00:00:00
abstract::Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623317721748
更新日期:2017-07-01 00:00:00
abstract::The B6C3F1 strain of mice is prone to develop liver nodules as animals grow older. This spontaneous tumor development is enhanced by dietary lipotrope deficiency. The present studies were performed to evaluate the liver of the B6C3F1 mice in early periods of lipotrope deficiency and before the nodules appear. Mice wer...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338501300103
更新日期:1985-01-01 00:00:00
abstract::Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg)...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262338901700114
更新日期:1989-01-01 00:00:00
abstract::The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623314559103
更新日期:2015-06-01 00:00:00
abstract::S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339502300405
更新日期:1995-07-01 00:00:00
abstract::In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for monitoring this pathology preclinically or clinically. Furthermore, our current understanding of the pathogenesis of this lesion is limited. While vasodilatatio...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1080/01926230500512076
更新日期:2006-01-01 00:00:00
abstract::The expression of specific cytokeratin (CK) polypeptide patterns is a sensitive marker of the cytoskeletal differentiation of epithelial cells. We developed an immunohistochemical method to assess CK expression patterns in the rat respiratory tract using serial paraffin-embedded sections from the nasal cavity, trachea...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339802600308
更新日期:1998-05-01 00:00:00
abstract::Epidemiological associations have been made between the new onset of childhood rhinitis/asthma and exposures to elevated ambient levels of ozone, a commonly encountered gaseous air pollutant. Our laboratory was the first to find that mice repeatedly exposed to ozone develop nasal type 2 immunity and eosinophilic rhini...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623319873872
更新日期:2019-12-01 00:00:00
abstract::A number of novel urinary biomarkers have been identified and partially qualified for use as markers for renal injury in rats. We used two multiplex assays for these novel biomarkers to quantify biomarker concentration in serial urine collections from rats of both sexes administered varying concentrations of cisplatin...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623311432436
更新日期:2012-04-01 00:00:00
abstract::One of the biggest challenges in drug development is interpretation of findings suggestive of immunostimulation, particularly when the findings are unexpected based on the known mechanism of action of the drug. Findings suggestive of immunostimulation do not necessarily preclude development of the drug. By understandi...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313513075
更新日期:2014-10-01 00:00:00
abstract::Regulatory guidelines for nonclinical neurotoxicity testing require spinal cord evaluation but do not specify a trimming scheme. The Society of Toxicologic Pathology (STP) "best practices" for nervous system sampling during nonclinical general toxicity studies recommend that spinal cord be assessed in both longitudina...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623317720120
更新日期:2017-07-01 00:00:00
abstract::The identification, recording, and interpretation of nasal lesions can be a difficult task in toxicology studies. The objective of this article is to provide some guidelines for approaches to nasal toxicologic pathology, based on the author's experience and information available in the published literature. Identifica...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623391019004-103
更新日期:1991-01-01 00:00:00
abstract::Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339101900210
更新日期:1991-01-01 00:00:00
abstract::The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230600773941
更新日期:2006-01-01 00:00:00
abstract::Recommendations (best practices) are provided by the Society of Toxicologic Pathology's Adversity Working Group for making consistent interpretations of test article-related effects as "adverse" and assigning a "no observed adverse effect level" (NOAEL) in nonclinical toxicity studies. Adverse is a term indicating "ha...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623315623265
更新日期:2016-02-01 00:00:00
abstract::Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubulog...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623318796784
更新日期:2018-12-01 00:00:00
abstract::The mouse liver is the primary target site for carcinogenesis of more than 200 chemicals (including pesticides, food additives, pharmaceuticals, and industrial intermediates) tested in long-term toxicity safety assessment assays. Mouse liver tumors develop through defined morphological stages (similar to those found i...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262339602400117
更新日期:1996-01-01 00:00:00
abstract::Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623313486316
更新日期:2014-01-01 00:00:00
abstract::Novel biomarkers are often required in the preclinical development of biopharmaceuticals in order to characterize pharmacologic and toxicologic effects and to establish pharmacodynamic and pharmacokinetic relationships. Flow cytometry is uniquely suited for measurement of these biomarkers. Large numbers of single cell...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/019262339902700107
更新日期:1999-01-01 00:00:00
abstract::Cyclodextrins are oligosaccharides which are used in the pharmaceutical industry and research as vehicles for application of apolar substances such as steroids. The aim of this study was to examine the long-term effects of parenteral administration of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on bone. Sham-operated (SH...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623312441405
更新日期:2012-07-01 00:00:00
abstract::Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230490440925
更新日期:2004-07-01 00:00:00
abstract::Selenoprotein P is an abundant extracellular protein that is expressed in liver, brain, and other tissues. Studies in mice with the selenoprotein P gene deleted (Sepp-/- mice) have implicated the protein in maintaining brain selenium. Sepp-/- mice fed a normal or low selenium diet develop severe motor impairment and d...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230500243045
更新日期:2005-01-01 00:00:00
abstract::The 2018 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Indianapolis, Indiana, at the Society of Toxicologic Pathology's 37th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This arti...
journal_title:Toxicologic pathology
pub_type:
doi:10.1177/0192623318800734
更新日期:2018-12-01 00:00:00
abstract::Progressive renal interstitial fibrosis occurs following tissue injury, resulting in chronic renal failure. In the fibrogenesis, macrophages are speculated to induce myofibroblasts producing matrix protein. The kinetics of these cells in renal fibrosis induced in rats by repeated injection of cisplatin (CDDP) (2 mg/kg...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/019262339602400208
更新日期:1996-03-01 00:00:00
abstract::Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotoxic and will induce mouse hepatocellular tumors and/or rat thyroid fol...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1080/01926230601047808
更新日期:2006-01-01 00:00:00
abstract::To investigate pathogenesis of post-bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg body weight) and rats were observed for 12 days. On days 1 to 2, cholangiocytes were injured and desquamated. On days 3 to 5...
journal_title:Toxicologic pathology
pub_type: 杂志文章
doi:10.1177/0192623311413790
更新日期:2011-08-01 00:00:00
abstract::A variety of phenotypic cellular changes emerge in the liver of different species prior to the appearance of hepatocellular adenomas and carcinomas induced by carcinogenic agents (chemicals, radiation, hepadna viruses) or develop "spontaneously." Foci of altered hepatocytes have been studied most extensively in rats t...
journal_title:Toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1177/0192623389017004107
更新日期:1989-01-01 00:00:00