Emerging issues in mouse liver carcinogenesis.

abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...

journal_title：Toxicologic pathology

authors： Kashida Y,Kato M

更新日期：1997-11-01 00:00:00

abstract：:Macrophages appearing in lesions are polarized toward M1 (for inflammation) and M2 (for anti-inflammation/fibrosis) types. We analyzed immunophenotypes of macrophages appearing in myocardial lesion in rats injected once with isoproterenol (10 mg/kg body weight). Inflammation following myocardial necrosis on day 1 was ...

journal_title：Toxicologic pathology

authors： Koga M,Karim MR,Kuramochi M,Izawa T,Kuwamura M,Yamate J

更新日期：2021-01-05 00:00:00

abstract：:Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...

journal_title：Toxicologic pathology

authors： Parkinson A

更新日期：1996-01-01 00:00:00

abstract：:The preclinical safety of RPR 106541, a novel 17-thiosteroid, was evaluated in young adult and mature dogs by inhalation exposure for 26 weeks and 52 weeks, respectively. A dry powder formulation of RPR 106541 in lactose was administered to young adult dogs (approximately 6 months of age at initiation) at doses of 0 (...

journal_title：Toxicologic pathology

authors： Miller GK,Valerio MG,Pino MV,Larson JL,Viau A,Hamelin N,Labbé R,Banks CM

更新日期：2000-03-01 00:00:00

abstract：:Whole mount enzyme histochemistry to localize lacZ-bearing transgenes (lacZ-WMH) also detects endogenous beta-galactosidases. The experiments reported here evaluated lacZ-WMH as a potential tool for transgene expression analysis during high-throughput rodent necropsies. A lacZ-WMH survey of organs from adult, wild-typ...

journal_title：Toxicologic pathology

authors： Bolon B

更新日期：2008-02-01 00:00:00

abstract：:The effects of oral contraceptives have been studied in the beagle bitch for periods up to 7 yr. High doses of these potent estrogen: progestogen (E:P) combinations have been shown to promote tumors in the mammary glands, smooth muscle of the tubular genitalia, and occasionally in the transitional epithelium of the ne...

journal_title：Toxicologic pathology

authors： Johnson AN

更新日期：1989-01-01 00:00:00

abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...

journal_title：Toxicologic pathology

authors： Imaida K,Furihata C,Tatematsu M,Yoon CH,Furukawa F,Uneyama C,Takahashi M,Ito N,Hayashi Y

更新日期：1991-01-01 00:00:00

abstract：:The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and biochemistry of minipigs are similar enough to humans to consider them as ...

journal_title：Toxicologic pathology

authors： Colleton C,Brewster D,Chester A,Clarke DO,Heining P,Olaharski A,Graziano M

更新日期：2016-04-01 00:00:00

abstract：:To characterize the hepatic lesions in Fischer 344 (F344) rats afflicted with large granular lymphocyte (LGL) leukemia, the livers of rats with LGL leukemia at various stages were examined histopathologically and immunohistochemically. The morphologic features in the livers of rats afflicted with LGL leukemia were dif...

journal_title：Toxicologic pathology

authors： Shiga A,Narama I

更新日期：2015-08-01 00:00:00

abstract：:This experiment evaluated effects following chronic toxicity with 20 ppm fenvalerate (synthetic pyrethroid), 2 ppm monocrotophos (organophosphate) and 2 ppm endosulfan (chlorinated hydrocarbon) on bone health of broiler chicks. A total of 120 chicks were divided equally into 4 groups and were fed poultry mash without ...

journal_title：Toxicologic pathology

authors： Garg UK,Pal AK,Jha GJ,Jadhao SB

更新日期：2004-05-01 00:00:00

abstract：:Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in drug development. Despite over 20 years of pharmaceutical research, few ASOs have been marketed due to problems with clinical efficacy or preclinical toxicologic challenges. However, a number of recent developments have renewed i...

journal_title：Toxicologic pathology

authors： Frazier KS

更新日期：2015-01-01 00:00:00

abstract：:Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glu...

journal_title：Toxicologic pathology

authors： Sandelius Å,Basak J,Hölttä M,Sultana S,Hyberg G,Wilson A,Andersson P,Söderberg M

更新日期：2020-12-01 00:00:00

abstract：:In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasal cavity was included for examination. Histology revealed extensive n...

journal_title：Toxicologic pathology

authors： Damsch S,Eichenbaum G,Looszova A,Lammens L,Feyen B,Van den Bulck K,Knight E,Kelley M,Tonelli A

更新日期：2011-02-01 00:00:00

abstract：:Results of early nonclinical "General Toxicology" studies are used to set a safe starting dose for first-in-human (FIH) clinical trials. In FIH trials, the research subjects are typically healthy volunteers who have little to gain but much to lose if a trial goes wrong. With that in mind, good laboratory practice regu...

journal_title：Toxicologic pathology

authors： Seaton M

更新日期：2014-01-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the normal heart histology. It is therefore crucial to understand the normal v...

journal_title：Toxicologic pathology

authors： Chanut F,Kimbrough C,Hailey R,Berridge B,Hughes-Earle A,Davies R,Roland K,Stokes A,Casartelli A,York M,Jordan H,Crivellente F,Cristofori P,Thomas H,Klapwijk J,Adler R

更新日期：2013-01-01 00:00:00

abstract：:The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascu...

journal_title：Toxicologic pathology

authors： Morton D,Reed L,Huang W,Marcek JM,Austin-LaFrance R,Northcott CA,Schelling SH,Enerson BE,Tomlinson L

更新日期：2015-06-01 00:00:00

abstract：:The handling-induced dark neuron is a histological artifact observed in brain samples handled before fixation with aldehydes. To explore associations between dark neurons and immunohistochemical alterations in mouse brains, we examined protein products encoded by Cav3 (neuronal perikarya/neurites), Rbbp4 (neuronal nuc...

journal_title：Toxicologic pathology

authors： Soontornniyomkij V,Chang RC,Soontornniyomkij B,Schilling JM,Patel HH,Jeste DV

更新日期：2020-04-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

journal_title：Toxicologic pathology

authors： Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

更新日期：2014-01-01 00:00:00

abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...

journal_title：Toxicologic pathology

authors： Sayama A,Okado K,Nakamura K,Kawaguchi T,Iguchi T,Makino T,Yabe K,Kai K,Mori K

更新日期：2018-02-01 00:00:00

abstract：:Monocrotaline pyrrole (MCTP) is a highly reactive pneumotoxic metabolite of the pyrrolizidine alkaloid plant toxin monocrotaline. When administered to rats, it causes a delayed and progressive lung injury, vascular remodeling, and pulmonary hypertension. Structural remodeling consists of endothelial cell swelling foll...

journal_title：Toxicologic pathology

authors： Lappin PB,Roth RA

更新日期：1997-07-01 00:00:00

abstract：:Interrelationships among induction of cytochrome P-450 (CYP) 1A1/2, decrease in connexin 32 (Cx32), and liver tumor-promoting activity by beta-naphthoflavone (BNF) in the promotion stage were examined in a 2-stage liver carcinogenesis model. A total of 20 male Fischer 344 rats were initiated with a single intraperiton...

journal_title：Toxicologic pathology

authors： Shoda T,Mitsumori K,Onodera H,Toyoda K,Uneyama C,Takada K,Hirose M

更新日期：2000-07-01 00:00:00

abstract：:To investigate pathogenesis of post-bile duct (BD) injury fibrosis, interlobular BD epithelial injury was induced in male F344 rats by a single IP injection of α-naphthylisothiocyanate (75 mg/kg body weight) and rats were observed for 12 days. On days 1 to 2, cholangiocytes were injured and desquamated. On days 3 to 5...

journal_title：Toxicologic pathology

authors： Golbar HM,Izawa T,Yano R,Ichikawa C,Sawamoto O,Kuwamura M,Lamarre J,Yamate J

更新日期：2011-08-01 00:00:00

abstract：:In the context of human hematopathology, the terms myelodysplasia and Myelodysplastic Syndromes (MDS) are applied to disorders of hematopoiesis that are clonal, neoplastic, and, in most forms, manifested as ineffective hematopoiesis with characteristic morphologic abnormalities in multiple cell lines. Studies of human...

journal_title：Toxicologic pathology

authors： Blue JT

更新日期：2003-01-01 00:00:00

abstract：:The administration of mesenchymal stromal cells (MSCs) provides an exciting emerging therapeutic modality for the treatment of peripheral arterial disease, a condition that is associated with critical limb ischemia as its end stage. Placental-derived MSCs, termed PLX-PAD cells, are stable adhesive stromal cells isolat...

journal_title：Toxicologic pathology

authors： Ramot Y,Meiron M,Toren A,Steiner M,Nyska A

更新日期：2009-08-01 00:00:00

abstract：:The uterine cellular expression and distribution of c-fos, ERalpha and p38alpha was compared in humans, nonhuman primates, and rats using immunohistochemistry. ERalpha and c-fos were present in the glandular (GE) and luminal epithelial cells (LE) of humans and nonhuman primates, with differing expression patterns evid...

journal_title：Toxicologic pathology

authors： Radi ZA,Khan NK

更新日期：2006-01-01 00:00:00

abstract：:The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appea...

journal_title：Toxicologic pathology

authors： Cheng L,Ramesh AV,Flesken-Nikitin A,Choi J,Nikitin AY

更新日期：2010-01-01 00:00:00

abstract：:Chronic (24-month) inhalation exposure to 5 or 10 ppm allyl glycidyl ether (AGE) induced nasal lesions in Osborne-Mendel rats and B6C3F1 mice. Inflammation, degeneration, regeneration, metaplasia, hyperplasia, and neoplasia were observed in the nasal mucosa. Squamous metaplasia and hyperplasia of the respiratory epith...

journal_title：Toxicologic pathology

authors： Renne RA,Brown HR,Jokinen MP

更新日期：1992-01-01 00:00:00

abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...

journal_title：Toxicologic pathology

authors： Hayes TJ,Roberts GK,Halliwell WH

更新日期：1989-01-01 00:00:00