Pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides on bone health of broiler chicks.

abstract：:Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decr...

journal_title：Toxicologic pathology

authors： Walsh KM,Gough AW

更新日期：1989-01-01 00:00:00

abstract：:A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...

journal_title：Toxicologic pathology

authors： Butt MT

更新日期：2011-01-01 00:00:00

abstract：:Many common inflammatory disorders are characterized by the infiltration of neutrophils across epithelial lined (mucosal) surfaces resulting in disruption of critical barrier function that protects from microbes and noxious agents. In such conditions, disease symptoms are complex but directly related to leukocyte effe...

journal_title：Toxicologic pathology

authors： Matthews JD,Weight CM,Parkos CA

更新日期：2014-01-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak that started in Wuhan, China, in 2019 resulted in a pandemic not seen for a century, and there is an urgent need to develop safe and efficacious vaccines. The scientific community has made tremendous efforts to understand the disease, and unpara...

journal_title：Toxicologic pathology

authors： Bennet BM,Wolf J,Laureano R,Sellers RS

更新日期：2020-10-01 00:00:00

abstract：:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powde...

journal_title：Toxicologic pathology

authors： Wahlström E,Ollerstam A,Sundius L,Zhang H

更新日期：2013-08-01 00:00:00

abstract：:Apoptosis is a highly regulated mechanism of cell death. Although apoptosis has a functional role in normal development and tissue homeostasis, aberrant triggering of the process by toxicants may lead to abnormal function or disease. Low level exposures to toxicants that induce apoptosis in kidney may therefore create...

journal_title：Toxicologic pathology

authors： Davis MA,Ryan DH

更新日期：1998-11-01 00:00:00

abstract：:The toxicities of 2'-fluorouridine (2'-FU) and 2'-fluorocytidine-HCl (2'-FC) were separately evaluated in 2 species, male Fischer 344 (F334) rats and woodchucks. Particular attention was focused on the ability of these nucleosides to induce toxicities similar to those induced by the antiviral drug fialuridine (FIAU). ...

journal_title：Toxicologic pathology

authors： Richardson FC,Tennant BC,Meyer DJ,Richardson KA,Mann PC,McGinty GR,Wolf JL,Zack PM,Bendele RA

更新日期：1999-11-01 00:00:00

abstract：:The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section...

journal_title：Toxicologic pathology

authors： Mattsson JL

更新日期：2000-01-01 00:00:00

abstract：:The 2015 Annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri" was held in Minneapolis, Minnesota, at the American College of Veterinary Pathologists/American Society for Veterinary Clinical Pathology/Society of Toxicologic Pathology combined meeting. The goal of this symposium is to p...

journal_title：Toxicologic pathology

authors： Elmore SA,Farman CA,Hailey JR,Kovi RC,Malarkey DE,Morrison JP,Neel J,Pesavento PA,Porter BF,Szabo KA,Teixeira LB,Quist EM

更新日期：2016-06-01 00:00:00

abstract：:d-galactosamine (d-GalN) is a well-known hepatotoxic agent that causes liver injury. Conversely, hepatic macrophages play a crucial role in maintaining liver tissue integrity. Macrophage functions were investigated in hepatic lesions induced by a single intraperitoneal injection of d-GalN (800 mg/kg body weight [BW]) ...

journal_title：Toxicologic pathology

authors： Rahman N,Pervin M,Kuramochi M,Karim MR,Izawa T,Kuwamura M,Yamate J

更新日期：2018-10-01 00:00:00

abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...

journal_title：Toxicologic pathology

authors： Downes N,Mullins P

更新日期：2014-07-01 00:00:00

abstract：:The kerosene-type jet fuel, JP-8, consists of a complex mixture of aliphatic and aromatic hydrocarbons. Because of the utility of JP-8, studies have been conducted to identify the potential long-term consequence of occupational inhalation exposure. Fischer 344 rats and C57BL/6 mice of both sexes were exposed to JP-8 v...

journal_title：Toxicologic pathology

authors： Mattie DR,Alden CL,Newell TK,Gaworski CL,Flemming CD

更新日期：1991-01-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) refers to a decline in renal function following exposure to iodinated contrast media (CM). The present study was initiated to explore the role of known human risk factors (spontaneous hypertension, diabetes, protein-losing nephropathy) on CIN development in rodent models and to deter...

journal_title：Toxicologic pathology

authors： Rouse RL,Stewart SR,Thompson KL,Zhang J

更新日期：2013-01-01 00:00:00

abstract：:To clarify the cell of origin of granular cell tumors in the rat brain, light and/or electron microscopic examinations were performed on 40 cases of spontaneous meningeal tumors in Wistar (Jcl: Wistar) rats. The meningeal tumors were histologically subclassified into 3 types: meningothelial meningiomas (MMs), 3 cases;...

journal_title：Toxicologic pathology

authors： Yoshida T,Mitsumori K,Harada T,Maita K

更新日期：1997-03-01 00:00:00

abstract：:Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in drug development. Despite over 20 years of pharmaceutical research, few ASOs have been marketed due to problems with clinical efficacy or preclinical toxicologic challenges. However, a number of recent developments have renewed i...

journal_title：Toxicologic pathology

authors： Frazier KS

更新日期：2015-01-01 00:00:00

abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...

journal_title：Toxicologic pathology

authors： Ozaki K,Haseman JK,Hailey JR,Maronpot RR,Nyska A

更新日期：2002-03-01 00:00:00

abstract：:Parenteral administration of recombinant hematopoietic growth factors has been sporadically associated with cutaneous complications, including injection site reactions in humans and nonhuman primates. In this study, subcutaneous injection sites were evaluated from 12 cynomolgus monkeys administered a recombinant human...

journal_title：Toxicologic pathology

authors： Khan KN,Kats AA,Fouant MM,Snook SS,Mckearn JP,Alden CL,Smith PF

更新日期：1996-07-01 00:00:00

abstract：:Previous work in our laboratory revealed that the pubertal period of reproductive development in the male rat was particularly vulnerable to gossypol exposure, with a higher frequency of round structures in the lumen of the cauda epididymidis in the treated rats. Herein, we utilized hemicastration and electron microsc...

journal_title：Toxicologic pathology

authors： de Andrade SF,Oliva SU,Klinefelter GR,De Grava Kempinas W

更新日期：2006-01-01 00:00:00

abstract：:The usefulness of isolated adult cardiac myocytes, both in suspension and in culture, as a model system for measuring cardiotoxicity is evaluated. It has been suggested that isolated adult myocytes should preferably be cultured for such experimentation, as this restores the cells to a physiological preference for fatt...

journal_title：Toxicologic pathology

authors： Haworth RA,Goknur AB,Cook MG,Decker RS

更新日期：1990-01-01 00:00:00

abstract：:The objective was to determine the respiratory toxicity of MAP0004, orally inhaled dihydroergotamine (DHE), via inhalation for six months. Forty beagle dogs (twenty females, twenty males) were treated by nose-only inhalation for 182 days. Groups 2 through 5 received MAP0004 (mean doses: 0.045, 0.154, 0.44, 0.825 mg/kg...

journal_title：Toxicologic pathology

authors： Armer TA,Lynch M,Moutvic R,Singer A

更新日期：2011-04-01 00:00:00

abstract：:Osteogenic Protein-1 (OP-1) is a bone morphogen involved in tissue repair and development. We have shown that OP-1 is downregulated during acute ischemic renal injury. Here we report the use of the rat remnant kidney model (RRKM) to evaluate changes in kidney OP-1 expression during chronic injury, and determine if tre...

journal_title：Toxicologic pathology

authors： Dube PH,Almanzar MM,Frazier KS,Jones WK,Charette MF,Paredes A

更新日期：2004-07-01 00:00:00

abstract：:Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...

journal_title：Toxicologic pathology

authors： Esvelt MA,Freeman ZT,Pearson AT,Harkema JR,Clines GT,Clines KL,Dyson MC,Hoenerhoff MJ

更新日期：2019-02-01 00:00:00

abstract：:Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the normal heart histology. It is therefore crucial to understand the normal v...

journal_title：Toxicologic pathology

authors： Chanut F,Kimbrough C,Hailey R,Berridge B,Hughes-Earle A,Davies R,Roland K,Stokes A,Casartelli A,York M,Jordan H,Crivellente F,Cristofori P,Thomas H,Klapwijk J,Adler R

更新日期：2013-01-01 00:00:00

abstract：:Bioabsorbable implants can be advantageous for certain surgical tissue bioengineering applications and implant-assisted tissue repair. They offer the obvious benefits of nonpermanence and eventual restoration of the native tissue's biomechanical and immunological properties, while providing a structural scaffold for h...

journal_title：Toxicologic pathology

authors： Rousselle SD,Ramot Y,Nyska A,Jackson ND

更新日期：2019-04-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:Normal retina and its cell layers are essential for processing visual stimuli, and loss of its integrity has been documented in many disease processes. The numbers and the axonal processes of retinal ganglion cells are reduced substantially in glaucoma, leading to vision loss and blindness. Similarly, selective loss o...

journal_title：Toxicologic pathology

authors： Muthuswamy A,Chen H,Hu Y,Turner OC,Aina OH

更新日期：2020-12-31 00:00:00

abstract：:The Tg.AC mouse is being evaluated for use in short-term carcinogenicity bioassays. Because the dermal test protocol necessitates dissolving test agents we determined the effects of several solvents on responsiveness of hemizygous mice to dermal applications of the classical skin tumor promoter. phorbol 12-myristate 1...

journal_title：Toxicologic pathology

authors： Stoll RE,Furst SM,Stoltz JH,Lilly PD,Mennear JH

更新日期：2001-09-01 00:00:00

abstract：:The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. Mutat Res 356: 85-127). The SHE assay models the earliest identifiable stage in carcinogenicity, morphologi...

journal_title：Toxicologic pathology

authors： Mauthe RJ,Gibson DP,Bunch RT,Custer L

更新日期：2001-01-01 00:00:00

abstract：:B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the permissible exposure l...

journal_title：Toxicologic pathology

authors： Robledo RF,Young RS,Lantz RC,Witten ML

更新日期：2000-09-01 00:00:00

abstract：:Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by a highly developed innate defense system. Physiologically regulated epithelial ion and water transport coordinated with mucin secretion, beating cilia, and cough results in continuous flow of fluid and mucus over airway sur...

journal_title：Toxicologic pathology

authors： Livraghi A,Randell SH

更新日期：2007-01-01 00:00:00