Abstract:
:Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powder inhalation. The lung weight change was correlated with lung histopathology in the majority of studies (25 of 30), showing as either both changed or both unchanged. The sensitivity and specificity of using the weight change in lungs as biomarker for predicting lung histopathology in these studies were over 80%. The pattern of lung weight change was often similar in the 1- to 2- week studies and the 4-week studies. Our analysis of covariance model showed that a study with 40 rats (5 males + 5 females/group and 4 groups) could detect lung weight change greater than 10% to 20% of control value. These results suggested that lung weight is a useful indicator for identifying acute lung toxic effect by inhaled compounds in these subacute inhalation studies.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Wahlström E,Ollerstam A,Sundius L,Zhang Hdoi
10.1177/0192623312470763subject
Has Abstractpub_date
2013-08-01 00:00:00pages
902-12issue
6eissn
0192-6233issn
1533-1601pii
0192623312470763journal_volume
41pub_type
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