Abstract：
:Congenital anomalies of the alimentary tract are rare lesions in laboratory animals. We describe a congenital cyst attached to the greater curvature of the forestomach in a B6C3F1 mouse. The inner surface of the cyst was mostly covered with cuboidal or pseudostratified ciliated epithelium and was focally covered with the flat cuboidal epithelium. The base of the cyst appeared to be inserted between the layers of the outer longitudinal muscle layer of the forestomach, although no smooth muscle layer was evident in the free surface of the cyst wall. The cyst resembled duplication of the alimentary tract, as it was lined with ciliated epithelium and had developed at the greater curvature of the forestomach. Since the smooth muscle layer did not completely cover the whole wall and the cyst did not communicate with the gastric lumen, the cyst was not thought to be a standard duplication but rather a simple congenital cyst.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Miyajima R,Kihara T,Hosoi M,Yamamoto S,Mikami S,Yamakawa S,Iwata H,Enomoto Mdoi
10.1177/019262339902700514subject
Has Abstractpub_date
1999-09-01 00:00:00pages
600-3issue
5eissn
0192-6233issn
1533-1601journal_volume
27pub_type
杂志文章abstract：:Vaginal exfoliative cytology is commonly used in biomedical and toxicological research to classify the stages of the rodent estrous cycle. However, mouse vaginal exfoliative cytology is commonly used as a stand-alone tool and has not been evaluated in reference to vaginal histology and serum sex hormone levels. In thi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314526321
更新日期：2014-12-01 00:00:00
abstract：:We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600206
更新日期：1998-03-01 00:00:00
abstract：:The relatively high incidence and variety of lesions induced in the upper respiratory tract of rodents by inhalation of xenobiotics has resulted in considerable attention given to the microscopic anatomy of this area. Specific areas of the rodent laryngeal mucosa appear to be more sensitive to inhaled materials and mo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339202000106
更新日期：1992-01-01 00:00:00
abstract：:Determining the carcinogenic potential of materials to which humans have significant exposures is an important, complex, and imperfect exercise. Not only are the methods for such determinations protracted and expensive and use large numbers of animals, extrapolation of data from such studies to human risk is imprecise...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309351892
更新日期：2010-01-01 00:00:00
abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317749469
更新日期：2018-02-01 00:00:00
abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300309
更新日期：1985-01-01 00:00:00
abstract：:Chronic ingestion of arsenic is associated with increased incidence of respiratory and cardiovascular diseases. To investigate the role of arsenic in early events in vascular pathology, C57BL/6 mice ingested drinking water with or without 50 ppb sodium arsenite (AsIII) for four, five, or eight weeks. At five and eight...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623308323919
更新日期：2008-10-01 00:00:00
abstract：:Epidemiological associations have been made between the new onset of childhood rhinitis/asthma and exposures to elevated ambient levels of ozone, a commonly encountered gaseous air pollutant. Our laboratory was the first to find that mice repeatedly exposed to ozone develop nasal type 2 immunity and eosinophilic rhini...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623319873872
更新日期：2019-12-01 00:00:00
abstract：:Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 w...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300602
更新日期：1995-11-01 00:00:00
abstract：:Carbonyl sulfide (COS) is an odorless gas that produces highly reproducible lesions in the central nervous system. In the present study, the time course for the development of the neurotoxicological lesions was defined and the gene expression changes occurring in the posterior colliculus upon exposure to COS were char...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309335631
更新日期：2009-06-01 00:00:00
abstract：:Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubulog...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623318796784
更新日期：2018-12-01 00:00:00
abstract：:During preclinical investigations into the safety of drugs and chemicals, many are found to interfere with reproductive function in the female rat. This interference is commonly expressed as a change in normal morphology of the reproductive tract or a disturbance in the duration of particular phases of the estrous cyc...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623308315665
更新日期：2008-04-01 00:00:00
abstract：:S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced nephrotoxicity in vivo was investigated in New Zealand White rabbits. A primary emphasis in these studies was further characterization of DCVC-induced nephrotoxicity using a variety of serum and urinary analytes, including sodium dodecyl sulfate-polyacrylamide gel electr...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300405
更新日期：1995-07-01 00:00:00
abstract：:In standard toxicity studies, the cardiac conduction tissue is not systematically sampled and examined for histopathological changes. Most methods described use serial sectioning perpendicular to the long axis of the sinoauricular node (SAN) and atrioventricular node (AVN). Dozens of slides are needed to allow examina...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300107
更新日期：1995-01-01 00:00:00
abstract：:The spleen contains hematopoietic and lymphoid elements, is a primary site of extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well as particulate materials and circulating bacteria from the blood supply. Lesions of this important component of the immune system may center on the red pul...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230600867750
更新日期：2006-01-01 00:00:00
abstract：:Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318816295
更新日期：2019-02-01 00:00:00
abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230590908231
更新日期：2005-01-01 00:00:00
abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317721748
更新日期：2017-07-01 00:00:00
abstract：:We describe 2 cases of a relatively rare tumor diagnosed as pituicytoma in the pars nervosa of rat pituitary. This tumor was spontaneously noted in one 110-week-old female and one 109-week-old male Fischer 344 (F344)/DuCrj rats during 2-year carcinogenicity studies. Although no gross abnormality of the pituitary was d...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800612
更新日期：2000-11-01 00:00:00
abstract：:Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have investigated the potential of furan to induce oxidative stress and DNA damage associated with inflammatory and regenerative responses in rat liver. Furan was ad...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309357946
更新日期：2010-02-01 00:00:00
abstract：:Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The toxic effects of a mixture of 2-aminoanthracene (2-AA), benzanthracene (BA), and dinitropyrene isomers (DNP), and the toxic effects of these compounds individually, were investigated in the Fischer-344 rat following dietary exposure via a powdered basal diet. Animals were sacrificed at 14-, 30-, and 80-days of die...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262301316905291
更新日期：2001-05-01 00:00:00
abstract：:Cysteamine is the first chemical identified that induces acute and chronic duodenal ulcers in rodents. Structure-activity studies with cysteamine, propionitrile and their derivatives, as well as with analogues of toluene, revealed numerous alkyl and aryl duodenal ulcerogens. Among these, one of the most interesting fr...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338801600213
更新日期：1988-01-01 00:00:00
abstract：:In non-rodent toxicity studies supporting pharmaceutical or chemical product registration, the value of histopathology evaluation of all tissues from all animals from all dose groups is an ongoing discussion topic among pathologists. This manuscript documents an examination of this topic through a retrospective review...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312439642
更新日期：2012-07-01 00:00:00
abstract：:There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) techniques and of ocular relevant immunohistochemistry (IHC) or in situ hybrid...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315615553
更新日期：2016-04-01 00:00:00
abstract：:Cyclodextrins are oligosaccharides which are used in the pharmaceutical industry and research as vehicles for application of apolar substances such as steroids. The aim of this study was to examine the long-term effects of parenteral administration of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on bone. Sham-operated (SH...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623312441405
更新日期：2012-07-01 00:00:00
abstract：:High-resolution digitalizing of histology slides facilitates the development of computational alternatives to manual quantitation of features of interest. We developed a MATLAB-based quantitative histological analysis tool (QuHAnT) for the high-throughput assessment of distinguishable histological features. QuHAnT val...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314544379
更新日期：2015-04-01 00:00:00
abstract：:Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F1 mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The most frequently occurring neoplasms in untreated male F344 rats were testicular adenoma (89.1%), mononuclear cell leukemia (5...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600318
更新日期：1998-05-01 00:00:00
abstract：:The dose dependence of L-ascorbic acid (AsA) copromotion of urinary bladder carcinogenesis with continuous concomitant administration of NaHCO3 was investigated. In the first experiment, 83 male F344 rats were all given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 wk and then divided into 5 groups, which re...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339702500306
更新日期：1997-05-01 00:00:00
abstract：:Sensitive kidney safety assessment is important for successful drug development in both preclinical and clinical stages. The Food and Drug Administration recently qualified a composite measure of 6 urine creatinine-normalized biomarkers, such as clusterin, cystatin C, kidney injury molecule 1 (KIM-1), N-acetyl-β-d-glu...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623320964391
更新日期：2020-12-01 00:00:00
