Spontaneous vesicular and prostatic gland epithelial squamous metaplasia, hyperplasia, and keratinized nodule formation in rabbits.

Abstract:

:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia and hyperplasia without metaplasia. The affected cells were taller with pale cytoplasm and a prominent basophilic nucleus longitudinally oriented and increased in number compared to more normal adjacent epithelium. Thirty-one (41%) of the Dutch Belted and 10 (45%) of the New Zealand White males showed one or more nodules of squamous metaplasia in the alveolar epithelial lining or seen occasionally within alveolar walls of the vesicular gland. The prostate was less commonly affected and none of the early cellular atypia or later cornification changes were seen. A few cornified nodules with mitotic figures resembled "carcinoma in situ," but the morphology and available biologic data supported the judgment that the lesion was benign, metaplastic, proliferative, and clinically silent.

journal_name

Toxicol Pathol

journal_title

Toxicologic pathology

authors

Zwicker GM,Killinger JM,McConnel RF

doi

10.1177/019262338501300309

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

222-8

issue

3

eissn

0192-6233

issn

1533-1601

journal_volume

13

pub_type

杂志文章
  • Fluorescence measurements of DNA-bound metabolites of benzo(a)pyrene derivatives with different carcinogenic effects.

    abstract::(+/-)-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-diol) and 9-hydroxybenzo(a)pyrene (9-OH-BP) were metabolized by rat liver microsomes in the presence of calf thymus DNA, resulting in preferential DNA binding of fluorescent (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) and 9-OH-BP-4,5-epoxide, respectively. When the ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338401200211

    authors: Gräslund A,Jernström B,Undeman O,Dock L,Ehrenberg A,Astlind T

    更新日期:1984-01-01 00:00:00

  • Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials.

    abstract::Novel urinary protein biomarkers for the detection of acute renal damage, recently accepted by the U.S. Food and Drug Administration, European Medicines Agency, and Pharmaceuticals and Medical Devices Agency (Japan), now have to be validated in practice. Limited data regarding the performance of these acute markers af...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623312444618

    authors: Fuchs TC,Frick K,Emde B,Czasch S,von Landenberg F,Hewitt P

    更新日期:2012-10-01 00:00:00

  • Deciphering Sources of Variability in Clinical Pathology.

    abstract::The objectives of this session were to explore causes of variability in clinical pathology data due to preanalytical and analytical variables as well as study design and other procedures that occur in toxicity testing studies. The presenters highlighted challenges associated with such variability in differentiating te...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623316675766

    authors: Tripathi NK,Everds NE,Schultze AE,Irizarry AR,Hall RL,Provencher A,Aulbach A

    更新日期:2017-01-01 00:00:00

  • Enhanced histopathology of the spleen.

    abstract::The spleen is the largest secondary lymphoid organ, is considered the draining site for compounds that are administered intravenously, and is therefore considered an important organ to evaluate for treatment-related lesions. Due to the presence of B and T lymphocytes, the immunotoxic effects of xenobiotics or their me...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01926230600865523

    authors: Elmore SA

    更新日期:2006-01-01 00:00:00

  • New findings concerning eosinophilic substance deposition in mouse nasal septum: sex difference and no increase in seniles.

    abstract::An eosinophilic substance (ES) is usually observed in the mouse nasal septum. In contrast to textbooks and one report describing ES as amyloid, a previous study by the authors revealed that ES is not amyloid but consists of collagen and an amorphous material. Furthermore, it was suggested that the amorphous material w...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623310367805

    authors: Doi T,Kokoshima H,Kanno T,Sato J,Wako Y,Tsuchitani M,Matsui T

    更新日期:2010-06-01 00:00:00

  • From cysteamine to MPTP: structure-activity studies with duodenal ulcerogens.

    abstract::Cysteamine is the first chemical identified that induces acute and chronic duodenal ulcers in rodents. Structure-activity studies with cysteamine, propionitrile and their derivatives, as well as with analogues of toluene, revealed numerous alkyl and aryl duodenal ulcerogens. Among these, one of the most interesting fr...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1177/019262338801600213

    authors: Szabo S,Cho CH

    更新日期:1988-01-01 00:00:00

  • Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.

    abstract::Oltipraz, developed as an antischistosomal agent, protects against the hepatotoxicity of many xenobiotics and is known to be an effective inhibitor of experimental carcinogenesis in rodents. In the present study, we investigated its effects on the development of lesions in LEC rats, established as a mutant strain char...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/019262302753559506

    authors: Nakamura H,Nishikawa A,Furukawa F,Kasahara K,Miyauchi M,Okazaki K,Imazawa T,Uchida K,Hirose M

    更新日期:2002-03-01 00:00:00

  • The role of metabolism in chemical-induced pulmonary toxicity.

    abstract::The lung is a target organ for the toxic effects of several chemical agents, including natural products, industrial chemicals, pesticides, environmental agents, and occasionally, drugs. Factors that establish the lung as a target organ include selective tissue exposure, high tissue oxygenation, and the presence of bio...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1177/019262339101900415

    authors: Smith BR,Brian WR

    更新日期:1991-01-01 00:00:00

  • Use of rat liver altered focus models for testing chemicals that have completed two-year carcinogenicity studies.

    abstract::Partial hepatectomy (PH) and neonatal rat short-term liver focus models were used to examine the effects of selected chemicals that had been previously tested in the National Toxicology Program (NTP) 2-yr carcinogenicity studies. C.I. Solvent Yellow 14, monuron, chlorendic acid, and 4-hydroxyacetanilide were tested fo...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623389017004110

    authors: Maronpot RR,Pitot HC,Peraino C

    更新日期:1989-01-01 00:00:00

  • Summary of panel discussion: past, present and future of toxicologic pathologists and the contributions to hazard identification and molecular mechanisms of action.

    abstract::One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to de...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/019262301301418973

    authors: Miller RT,Davis BJ

    更新日期:2001-01-01 00:00:00

  • Accumulation of iron in the rat lung after tracheal instillation of diesel particles.

    abstract::Oxidant generation catalyzed by metals has been postulated to account for a lung injury following exposure to air pollution particles. In particles that are predominantly carbonaceous, it is difficult to implicate such an oxidative stress as the responsible mechanism, since concentrations of metals can be extremely lo...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262330002800416

    authors: Ghio AJ,Richards JH,Carter JD,Madden MC

    更新日期:2000-07-01 00:00:00

  • Ocular irritation: pathological changes occurring in the rat with surfactants of unknown irritancy.

    abstract::We believe the development and validation of in vitro alternatives to eliminate the need to use animals in ocular irritation testing must be based on a thorough understanding of the mechanisms of ocular irritation. We have recently undertaken the task of developing such an understanding for a panel of surfactants. The...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339802600206

    authors: Maurer JK,Parker RD,Carr GJ

    更新日期:1998-03-01 00:00:00

  • Erratum.

    abstract::Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,已发布勘误

    doi:10.1177/0192623317702643

    authors:

    更新日期:2017-04-01 00:00:00

  • An overview of atherosclerosis: a look to the future.

    abstract::This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible me...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Getz GS

    更新日期:1990-01-01 00:00:00

  • 3,4,3',4'-tetrachlorobiphenyl-induced effects in the rat liver. I. Serum and hepatic retinoid reduction and morphologic changes.

    abstract::The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262338901700308

    authors: Durham SK,Brouwer A

    更新日期:1989-01-01 00:00:00

  • Epididymal sperm granuloma induced by chronic administration of 2-methylimidazole in B6C3F1 mice.

    abstract::Two-year mouse and rat bioassay studies of 2-methylimidazole (2-MI) conducted by the National Toxicology Program revealed that epididymal sperm granuloma(SG)s occurred only in male B6C3F1 mice in a dose-related manner. The present study characterized 2-MI-induced SGs in these epididymides. Groups of 50 male B6C3F1 mic...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/01926230590922866

    authors: Tani Y,Foster PM,Sills RC,Chan PC,Peddada SD,Nyska A

    更新日期:2005-01-01 00:00:00

  • Parenteral solution of nutritional hepatotrophic factors improves regeneration in thioacetamide-induced cirrhotic livers after partial hepatectomy.

    abstract::Liver resection is a suitable option for the treatment of certain hepatic conditions, particularly hepatocarcinomas, in patients with cirrhosis. However, this disease impairs liver regeneration, which increases the risk of liver failure and postoperative death. Supportive treatments for regeneration of the remaining l...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623313486316

    authors: Trotta Mde R,Cajaiba DM,Parra OM,Dagli ML,Hernandez-Blazquez FJ

    更新日期:2014-01-01 00:00:00

  • Myelodysplasia: differentiating neoplastic from nonneoplastic syndromes of ineffective hematopoiesis in dogs.

    abstract::In the context of human hematopathology, the terms myelodysplasia and Myelodysplastic Syndromes (MDS) are applied to disorders of hematopoiesis that are clonal, neoplastic, and, in most forms, manifested as ineffective hematopoiesis with characteristic morphologic abnormalities in multiple cell lines. Studies of human...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01926230390177659

    authors: Blue JT

    更新日期:2003-01-01 00:00:00

  • Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats.

    abstract::We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339502300315

    authors: Kato M,Takada S,Kashida Y,Nomura M

    更新日期:1995-05-01 00:00:00

  • Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.

    abstract::Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide for long-acting delivery. The toxicity of a single intravitreal dose o...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623320969124

    authors: Laing ST,Tassew N,Tesar D,Wang Y,Crowell SR,Gray J,Kwong M,Loyet KM,Andaya R,Kusi A,Kelley RF

    更新日期:2020-12-21 00:00:00

  • The role of the pathologist in GLP studies.

    abstract::This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623313506521

    authors: Weber K,Hailey JR,Mann PC,Seaton M,Funk KA

    更新日期:2014-01-01 00:00:00

  • Long-term parenteral administration of 2-hydroxypropyl-β-cyclodextrin causes bone loss.

    abstract::Cyclodextrins are oligosaccharides which are used in the pharmaceutical industry and research as vehicles for application of apolar substances such as steroids. The aim of this study was to examine the long-term effects of parenteral administration of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on bone. Sham-operated (SH...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623312441405

    authors: Kantner I,Erben RG

    更新日期:2012-07-01 00:00:00

  • Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice.

    abstract::Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epit...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623318779326

    authors: Suen AA,Jefferson WN,Williams CJ,Wood CE

    更新日期:2018-07-01 00:00:00

  • Passive role of articular chondrocytes in quinolone-induced arthropathy in guinea pigs.

    abstract::The role of articular chondrocytes and matrix degrading enzymes such as collagenase and neutral protease in the pathogenesis of quinolone-induced cartilage degeneration was investigated in immature guinea pigs. Articular cartilage from nalidixic acid (NA) treated guinea pigs was examined for the presence of protease a...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/019262339001800209

    authors: Bendele AM,Hulman JF,Harvey AK,Hrubey PS,Chandrasekhar S

    更新日期:1990-01-01 00:00:00

  • Effects of chronic exposure to air pollution from Sao Paulo city on coronary of Swiss mice, from birth to adulthood.

    abstract::To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623309332994

    authors: Akinaga LM,Lichtenfels AJ,Carvalho-Oliveira R,Caldini EG,Dolhnikoff M,Silva LF,Bueno HM,Pereira LA,Saldiva PH,Garcia ML

    更新日期:2009-04-01 00:00:00

  • Effects of a cyclooxygenase-2 preferential inhibitor in young healthy dogs exposed to air pollution: a pilot study.

    abstract::Residency in cities with high air pollution is associated with neuroinflammation and neurodegeneration in healthy children, young adults, and dogs. Nonsteroidal anti-inflammatory drugs may offer neuroprotection. The authors measured the plasma concentrations of 3-nitrotyrosine and the cerebro-spinal-fluid concentratio...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623309340277

    authors: Calderón-Garcidueñas L,Mora-Tiscareño A,Gómez-Garza G,Carrasco-Portugal Mdel C,Pérez-Guillé B,Flores-Murrieta FJ,Pérez-Guillé G,Osnaya N,Juárez-Olguín H,Monroy ME,Monroy S,González-Maciel A,Reynoso-Robles R,Villarreal-Calderon

    更新日期:2009-08-01 00:00:00

  • Troponin as a biomarker of cardiac toxicity: past, present, and future.

    abstract::Cardiac troponin (cTn) is a sensitive and specific biomarker for assessing cardiac damage and should be utilized in drug safety assessment. Lactate dehydrogenase and creatine kinase isoenzyme analyses have historically been used in pre-clinical toxicity testing to assess cardiac injury, but since these assays are less...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623310382438

    authors: Reagan WJ

    更新日期:2010-12-01 00:00:00

  • The study pathologist's role in GLP studies: a regulator's perspective.

    abstract::Results of early nonclinical "General Toxicology" studies are used to set a safe starting dose for first-in-human (FIH) clinical trials. In FIH trials, the research subjects are typically healthy volunteers who have little to gain but much to lose if a trial goes wrong. With that in mind, good laboratory practice regu...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623313506878

    authors: Seaton M

    更新日期:2014-01-01 00:00:00

  • The syrian hamster embryo (SHE) cell transformation assay: review of the methods and results.

    abstract::The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. Mutat Res 356: 85-127). The SHE assay models the earliest identifiable stage in carcinogenicity, morphologi...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1080/019262301753178546

    authors: Mauthe RJ,Gibson DP,Bunch RT,Custer L

    更新日期:2001-01-01 00:00:00

  • Mission Accomplished: The ACVP/STP Coalition for Veterinary Pathology Fellows Completes Its Objectives, but Its Legacy and Spirit Live On.

    abstract::After 15 years of existence, the ACVP/STP Coalition for Veterinary Pathology Fellows will dissolve, primarily due to lack of renewed financial sponsorship. While in operation, the Coalition organized 32 new training position for veterinary pathologists, supported by $7.4 M from sponsors, including pharmaceutical and b...

    journal_title:Toxicologic pathology

    pub_type: 杂志文章

    doi:10.1177/0192623320917970

    authors: Adler R,Clark E,Cline M,Conner M,Crabbs T,Fossey S,Malarkey D,Meseck E,Vernau W,Tornquist S,McDorman K,Rees S,Cockerell G

    更新日期:2020-06-01 00:00:00