Abstract：
:Cysteamine is the first chemical identified that induces acute and chronic duodenal ulcers in rodents. Structure-activity studies with cysteamine, propionitrile and their derivatives, as well as with analogues of toluene, revealed numerous alkyl and aryl duodenal ulcerogens. Among these, one of the most interesting from an etiologic and pathogenetic point of view is the dopaminergic neurotoxin MPTP, which shows structural similarities with toluene. The chemically-induced duodenal ulcers are similar and localized on the anterior and posterior wall of the duodenal bulb. Both cysteamine and MPTP affect endogenous dopamine; MPTP is especially potent in depleting central dopamine and inducing lesions in the substantia nigra. MPTP given in high doses induces Parkinson's disease-like syndrome and gastric ulcers. Cysteamine and propionitrile also cause dyskinesia in large and multiple doses. The motility disorders and duodenal ulcers are abolished by dopamine agonists. Cysteamine and MPTP have been known to increase and decrease gastric acid secretion, respectively. However, both compounds induced duodenal dysmotility, decreased bicarbonate production, and reduced its delivery from distal to proximal duodenum. These factors decrease acid neutralization in the duodenal bulb and contribute to duodenal ulceration. Thus, studies with animal models may reveal endogenous mediators and specific receptors which might be involved in the pathogenesis of duodenal ulceration. Specific structure-activity studies in toxicology may lead to new insights in the pathogenesis and pharmacology of a poorly understood human disorder such as duodenal ulceration.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Szabo S,Cho CHdoi
10.1177/019262338801600213subject
Has Abstractpub_date
1988-01-01 00:00:00pages
205-12issue
2eissn
0192-6233issn
1533-1601journal_volume
16pub_type
杂志文章,评审abstract：:Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats us...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339702500615
更新日期：1997-11-01 00:00:00
abstract：:Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600507
更新日期：1998-09-01 00:00:00
abstract：:Groups of C57BL6 mice of each sex were assigned to one of 2 dietary regimens, ad libitum (AL) or dietary restriction (DR), to study effects of food restriction on body weight, survival, and neoplasia. The AL and DR groups were subdivided into a scheduled sacrifice group for examination at 6-mo intervals, and a lifetim...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300503
更新日期：1995-09-01 00:00:00
abstract：:Single doses of aspirin induce scattered foci of necrosis of proximal tubules in some strains of rats, whereas acute or sub-acute administration of phenylbutazone causes renal papillary necrosis. Initially, using Sprague-Dawley rats of CFY and CD strains, it became clear that these rats were not as susceptible to thes...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338601400214
更新日期：1986-01-01 00:00:00
abstract：:The nonnucleoside inhibitor (NNI) of HIV-1 reverse transcriptase, PHI-346 (N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea), is a dual-function spermicidal agent with potent anti-HIV activity against drug-sensitive as well as drug-resistant HIV-1 strains with genotypic and phenotypic NNI resistance. PHI-3...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230290168551
更新日期：2002-11-01 00:00:00
abstract：:With the increasing use of animal-based biomaterials for regenerative medical applications, the need for their safety assessment is paramount. A porcine cholecyst-derived scaffold (CDS), intended as a muscle repair graft, prepared by a nondetergent/enzymatic method was engrafted in a rat abdominal wall defect model. H...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317752894
更新日期：2018-02-01 00:00:00
abstract：:In a 13-week feeding toxicity study of grape skin extract (GSE) performed previously, 5.0% GSE showed diffuse hypertrophy and basophilia in rat parotid glands. To clarify whether the change in the parotid glands was an adverse effect of GSE, 6-week-old male F344 rats were fed a diet containing 5.0% GSE or were adminis...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623313512429
更新日期：2014-08-01 00:00:00
abstract：:Chronic (24-month) inhalation exposure to 5 or 10 ppm allyl glycidyl ether (AGE) induced nasal lesions in Osborne-Mendel rats and B6C3F1 mice. Inflammation, degeneration, regeneration, metaplasia, hyperplasia, and neoplasia were observed in the nasal mucosa. Squamous metaplasia and hyperplasia of the respiratory epith...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339202000311
更新日期：1992-01-01 00:00:00
abstract：:Weak peroxisome proliferator-activated receptor (PPAR) α agonists (fibrates) are used to treat dyslipidemia. This study compared the effects of the potent and selective PPARα agonist CP-778875 on peroxisomal β-oxidation and cardiac and/or skeletal muscle injury with those of the weak PPARα agonist fenofibrate. We hypo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311431945
更新日期：2012-04-01 00:00:00
abstract：:Zibotentan, an endothelin-A receptor antagonist, has been used in the treatment of various cardiovascular disorders and neoplasia. Castrated athymic nude mice receiving zibotentan for a preclinical xenograft efficacy study experienced weight loss, gastrointestinal bloat, and the presence of an audible respiratory clic...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623318816295
更新日期：2019-02-01 00:00:00
abstract：:The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic act...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/019262338701500310
更新日期：1987-01-01 00:00:00
abstract：:Gadolinium is used as a contrast media for magnetic resonance imaging and, experimentally, to block Kupffer cell phagocytosis. In this study, we utilize electron probe microanalysis to determine the subcellular localization of gadolinium chloride (GdCl3) administered to mice in a short-term toxicology study. Male CD-1...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339602400508
更新日期：1996-09-01 00:00:00
abstract：:The two-year rodent bioassay is one of several tests that are widely used by governmental regulatory agencies as well as pharmaceutical and chemical companies to determine the carcinogenic potential of chemicals or environmental agents where human exposure is anticipated. That this assay has remained relatively unchan...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230390201273
更新日期：2003-07-01 00:00:00
abstract：:We have previously indicated that the ideal animal tumor model should mimic the human disease. This means that the investigator should be able to ascertain the influence of host factors on the initiation of tumorigenesis, mimic the susceptibility of tumor response based on age and reproductive history, and determine t...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623314532036
更新日期：2015-02-01 00:00:00
abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339101900305
更新日期：1991-01-01 00:00:00
abstract：:Blood platelets play a fundamental role in hemostasis and thrombosis. The physiological role of platelets is to preserve the integrity of the cardiovascular system such that upon injury platelets are activated and serve to interrupt a potentially deleterious situation (i.e., hemorrhage). However, platelets are also in...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339302100210
更新日期：1993-01-01 00:00:00
abstract：:The kerosene-type jet fuel, JP-8, consists of a complex mixture of aliphatic and aromatic hydrocarbons. Because of the utility of JP-8, studies have been conducted to identify the potential long-term consequence of occupational inhalation exposure. Fischer 344 rats and C57BL/6 mice of both sexes were exposed to JP-8 v...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339101900201
更新日期：1991-01-01 00:00:00
abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317721748
更新日期：2017-07-01 00:00:00
abstract：:Histopathology of the reproductive system of 76 young adult Dutch Belted and 22 young adult or adult male New Zealand White rabbits was conducted as part of fertility studies. Thirty-five (46%) of the Dutch Belted and 11 (50%) of the New Zealand White males had multifocal vesicular gland basal epithelial cell atypia a...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338501300309
更新日期：1985-01-01 00:00:00
abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339101900210
更新日期：1991-01-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311422080
更新日期：2011-12-01 00:00:00
abstract：:We examined the localization and expression of the nuclear oncoprotein c-myc and the cytoplasmic membrane-associated oncoprotein c-ras in rainbow trout cell lines derived from both normal and tumor tissue in order to question whether c-myc and ras oncoprotein immunostaining was increased in cells derived from tumors c...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339602400310
更新日期：1996-05-01 00:00:00
abstract：:The carcinogenic potential of chloroform was evaluated in a short-term carcinogenicity testing system using CB6F1 rasH2-Tg (rasH2-Tg) mice. Chloroform was administered to rasH2-Tg males at doses of 28, 90, or 140 mg/kg and rasH2-Tg females at 24, 90, or 240 mg/kg by oral gavage for 26 weeks. Wild-type (non-Tg) male an...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/01926230252929909
更新日期：2002-05-01 00:00:00
abstract：:The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623316642527
更新日期：2016-08-01 00:00:00
abstract：:The coronavirus disease 2019 pandemic has affected business on numerous fronts in unprecedented and abrupt ways. From site closures and local "stay-at-home orders" to travel advisories and restrictions, the day-to-day practice of toxicologic pathology has been impacted dramatically and rapidly. A critical function of ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623320964087
更新日期：2020-12-01 00:00:00
abstract：:Biomass burning is a major source of indoor air pollution in rural India. The authors investigated in this study whether cumulative exposures to biomass smoke cause activation of the serine/threonine kinase Akt in airway cells and peripheral blood lymphocytes (PBL). For this, the authors enrolled 87 premenopausal (med...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310385139
更新日期：2010-12-01 00:00:00
abstract：:Kozlowski, C., Brumm, J., and Cain, G. (2018). An Automated Image Analysis Method to Quantify Veterinary Bone Marrow Cellularity on H&E Sections. Tox Path46, 324-335. (Original DOI: 10.1177/0192623318766457). Kozlowski, C., Fullerton, A., Cain, G., Katavolos, P., Bravo, J., and Tarrant, J. M. (2018). Proof of Concept ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,已发布勘误
doi：10.1177/0192623318794946
更新日期：2018-08-01 00:00:00
abstract：:Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339001800106
更新日期：1990-01-01 00:00:00
abstract：:One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to de...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262301301418973
更新日期：2001-01-01 00:00:00
abstract：:The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment. Male Balb/c mice received a single intraperitoneal injection of DENA (0, 2.5, 10.0, 25.0 or 50.0 micrograms/gbw) in saline on day 15 of age. N...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338801600310
更新日期：1988-01-01 00:00:00
