Significance of rat mammary tumors for human risk assessment.

abstract：:Glucokinase activators (GKAs) are being developed for the treatment of type 2 diabetes. The toxicity of 4 GKAs (PF-04279405, PF-04651887, piragliatin, and PF-04937319) was assessed in mice, rats, dogs, and/or monkeys. GKAs were administered for 2 to 8 weeks. Standard endpoints, glucose, and insulin were assessed. All ...

journal_title：Toxicologic pathology

authors： Pettersen JC,Litchfield J,Neef N,Schmidt SP,Shirai N,Walters KM,Enerson BE,Chatman LA,Pfefferkorn JA

更新日期：2014-06-01 00:00:00

abstract：:Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...

journal_title：Toxicologic pathology

authors： Nambiar PR,Turnquist SE,Morton D

更新日期：2012-06-01 00:00:00

abstract：:A delay in the exposure of initiated rats to orotic acid (OA) beyond a specific time frame results in a progressive loss of promotional effect in liver carcinogenesis. The current study was designed to ascertain whether the loss of promotional effect could be counteracted by pre-exposing the initiated animals to other...

journal_title：Toxicologic pathology

authors： Laconi E,Vasudevan S,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1987-01-01 00:00:00

abstract：:The 2018 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Indianapolis, Indiana, at the Society of Toxicologic Pathology's 37th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This arti...

journal_title：Toxicologic pathology

authors： Elmore SA,Carreira V,Labriola CS,Mahapatra D,McKeag SR,Rinke M,Shackelford C,Singh B,Talley A,Wallace SM,Wancket LM,Willson CJ

更新日期：2018-12-01 00:00:00

abstract：:Specific regions in the rodent larynx exhibit cellular changes in response to inhaled xenobiotics. These regions include the base of the epiglottis, ventral pouch, and medial surfaces of the vocal processes of the arytenoid cartilages. There are interspecies differences among laboratory rodents in the microscopic anat...

journal_title：Toxicologic pathology

authors： Renne RA,Sagartz JW,Burger GT

更新日期：1993-11-01 00:00:00

abstract：:Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is an important signaling enzyme downstream of immunoreceptors containing an intracellular immunoreceptor tyrosine activating motif (ITAM). These receptors encompass a wide variety of biological functions involved in autoimmune disease pathogenesis. Th...

journal_title：Toxicologic pathology

authors： Long AJ,Sampson E,McCarthy RW,Harris CM,Barnard M,Shi D,Conlon D,Caldwell R,Honor D,Wishart N,Hoemann M,Duggan L,Fritz D,Stedman C,O'Connor E,Mikaelian I,Schwartz A

更新日期：2016-10-01 00:00:00

abstract：:The lung is a target organ for the toxic effects of several chemical agents, including natural products, industrial chemicals, pesticides, environmental agents, and occasionally, drugs. Factors that establish the lung as a target organ include selective tissue exposure, high tissue oxygenation, and the presence of bio...

journal_title：Toxicologic pathology

authors： Smith BR,Brian WR

更新日期：1991-01-01 00:00:00

abstract：:In the context of human hematopathology, the terms myelodysplasia and Myelodysplastic Syndromes (MDS) are applied to disorders of hematopoiesis that are clonal, neoplastic, and, in most forms, manifested as ineffective hematopoiesis with characteristic morphologic abnormalities in multiple cell lines. Studies of human...

journal_title：Toxicologic pathology

authors： Blue JT

更新日期：2003-01-01 00:00:00

abstract：:Artemin (ART) signals through the GFR alpha-3/RET receptor complex to support sympathetic neuron development. Here we show that ART also influences autonomic elements in adrenal medulla and enteric and pelvic ganglia. Transgenic mice over-expressing Art throughout development exhibited systemic autonomic neural lesion...

journal_title：Toxicologic pathology

authors： Bolon B,Jing S,Asuncion F,Scully S,Pisegna M,Van GY,Hu Z,Yu YB,Min H,Wild K,Rosenfeld RD,Tarpley J,Carnahan J,Duryea D,Hill D,Kaufman S,Yan XQ,Juan T,Christensen K,McCabe J,Simonet WS

更新日期：2004-05-01 00:00:00

abstract：:Changes in p53 expression, apoptosis and cell proliferation after treatment with 4-hydroxyaminoquinoline 1-oxide (4HAQO) were investigated in the rat pancreas and liver, target and nontarget organs for tumorigenesis, respectively. Male rats were given a single intravenous injection of 4HAQO at a dose of 20 mg/kg body ...

journal_title：Toxicologic pathology

authors： Imazawa T,Nishikawa A,Toyoda K,Furukawa F,Mitsui M,Hirose M

更新日期：2003-11-01 00:00:00

abstract：:We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...

journal_title：Toxicologic pathology

authors： Kato M,Takada S,Kashida Y,Nomura M

更新日期：1995-05-01 00:00:00

abstract：:Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different stages of s...

journal_title：Toxicologic pathology

authors： Catlin NR,Huse SM,Boekelheide K

更新日期：2014-12-01 00:00:00

abstract：:Clinically, girls appear to be more sensitive than boys to the cardiotoxic effects of doxorubicin, whereas the opposite may be true for adults. To identify and characterize potential sex-related differences, adult male and female spontaneously hypertensive rats (SHR; some ovariectomized [OVX]) received 1 mg/kg of doxo...

journal_title：Toxicologic pathology

authors： Zhang J,Knapton A,Lipshultz SE,Cochran TR,Hiraragi H,Herman EH

更新日期：2014-01-01 00:00:00

abstract：:Focal spontaneously occurring eosinophilic hypertrophic cells, histomorphologically resembling oncocytes and hepatocytes, were observed in the pancreas from 11 (0.3%) of 4,177 Sprague-Dawley rats, 3 to 26 months old. The age of these eleven rats ranged from 13 to 25 months. The incidence was not different between sexe...

journal_title：Toxicologic pathology

authors： Chiu T

更新日期：1987-01-01 00:00:00

abstract：:Novel biomarkers are often required in the preclinical development of biopharmaceuticals in order to characterize pharmacologic and toxicologic effects and to establish pharmacodynamic and pharmacokinetic relationships. Flow cytometry is uniquely suited for measurement of these biomarkers. Large numbers of single cell...

journal_title：Toxicologic pathology

authors： Gossett KA,Narayanan PK,Williams DM,Gore ER,Herzyk DJ,Hart TK,Sellers TS

更新日期：1999-01-01 00:00:00

abstract：:In standard toxicity studies, the cardiac conduction tissue is not systematically sampled and examined for histopathological changes. Most methods described use serial sectioning perpendicular to the long axis of the sinoauricular node (SAN) and atrioventricular node (AVN). Dozens of slides are needed to allow examina...

journal_title：Toxicologic pathology

authors： Palate BM,Denoël SR,Roba JL

更新日期：1995-01-01 00:00:00

abstract：:Many goitrogenic xenobiotics that increase the incidence of thyroid tumors in rodents exert a direct effect on the thyroid gland to disrupt one of several possible steps in the biosynthesis, secretion, and metabolism of thyroid hormones. This includes (a) inhibition of the iodine trapping mechanism, (b) blockage of or...

journal_title：Toxicologic pathology

authors： Capen CC

更新日期：1997-01-01 00:00:00

abstract：:Pepsinogens are acid protease enzymes of pepsin usually found in gastric mucosa. In the present study, we demonstrated the presence of pepsinogen isozymes in male Syrian golden hamster lung tissues by a combined immunohistochemical and biochemical approach. Immunohistochemically, using rat pepsinogen 1 antibody, pepsi...

journal_title：Toxicologic pathology

authors： Imaida K,Furihata C,Tatematsu M,Yoon CH,Furukawa F,Uneyama C,Takahashi M,Ito N,Hayashi Y

更新日期：1991-01-01 00:00:00

abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...

journal_title：Toxicologic pathology

authors： Ozaki K,Haseman JK,Hailey JR,Maronpot RR,Nyska A

更新日期：2002-03-01 00:00:00

abstract：:Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...

journal_title：Toxicologic pathology

authors：

更新日期：2017-04-01 00:00:00

abstract：:Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control m...

journal_title：Toxicologic pathology

authors： Butler WH

更新日期：1996-07-01 00:00:00

abstract：:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, ...

journal_title：Toxicologic pathology

authors： Hayes TJ,Roberts GK,Halliwell WH

更新日期：1989-01-01 00:00:00

abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...

journal_title：Toxicologic pathology

authors： Schmidt F,Wolf R,Baumann L,Braunbeck T

更新日期：2017-07-01 00:00:00

abstract：:This continuing education course presented at the Society of Toxicologic Pathology's 31st Annual Symposium explored and defined the many roles that toxicologic pathologists serve Good Laboratory Practice (GLP)-conducted toxicology and carcinogenicity studies. ...

journal_title：Toxicologic pathology

authors： Weber K,Hailey JR,Mann PC,Seaton M,Funk KA

更新日期：2014-01-01 00:00:00

abstract：:In a simulated fire-related smoke exposure protocol, New Zealand white rabbits were utilized to investigate the potential effects of the 21-aminosteroid (lazaroid) analog U75412E on the early events of acute lung injury. Inhalation of a total of 1.6 mg/kg U75412E aerosolized at a rate of 1.53 mg/min at 0.5 hr after sm...

journal_title：Toxicologic pathology

authors： Wang S,Lantz RC,Robledo RF,Breceda V,Hays AM,Witten ML

更新日期：1999-05-01 00:00:00

abstract：:Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma forma...

journal_title：Toxicologic pathology

authors： Li Y,Wheeler DL,Ananthaswamy HN,Verma AK,Oberley TD

更新日期：2007-12-01 00:00:00

abstract：:Conazoles are a class of azole based fungicides used in agriculture and as pharmaceutical products. They have a common mode of antifungal action through inhibition of ergosterol biosynthesis. Some members of this class have been shown to be hepatotoxic and will induce mouse hepatocellular tumors and/or rat thyroid fol...

journal_title：Toxicologic pathology

authors： Wolf DC,Allen JW,George MH,Hester SD,Sun G,Moore T,Thai SF,Delker D,Winkfield E,Leavitt S,Nelson G,Roop BC,Jones C,Thibodeaux J,Nesnow S

更新日期：2006-01-01 00:00:00

abstract：:Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in drug development. Despite over 20 years of pharmaceutical research, few ASOs have been marketed due to problems with clinical efficacy or preclinical toxicologic challenges. However, a number of recent developments have renewed i...

journal_title：Toxicologic pathology

authors： Frazier KS

更新日期：2015-01-01 00:00:00

abstract：:The target organ specificities of cell proliferation and histopathological lesion induction by 5 carcinogens having different target organs were evaluated using a multiorgan carcinogenesis bioassay. In Group 1, male F-344 rats aged 6 wk were sequentially treated with N-diethylnitrosamine (DEN, single 100-mg/kg ip inje...

journal_title：Toxicologic pathology

authors： Yoshida Y,Tatematsu M,Takaba K,Iwasaki S,Ito N

更新日期：1993-09-01 00:00:00

abstract：:Macrophages appearing in lesions are polarized toward M1 (for inflammation) and M2 (for anti-inflammation/fibrosis) types. We analyzed immunophenotypes of macrophages appearing in myocardial lesion in rats injected once with isoproterenol (10 mg/kg body weight). Inflammation following myocardial necrosis on day 1 was ...

journal_title：Toxicologic pathology

authors： Koga M,Karim MR,Kuramochi M,Izawa T,Kuwamura M,Yamate J

更新日期：2021-01-05 00:00:00