Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment.

abstract：:The administration of mesenchymal stromal cells (MSCs) provides an exciting emerging therapeutic modality for the treatment of peripheral arterial disease, a condition that is associated with critical limb ischemia as its end stage. Placental-derived MSCs, termed PLX-PAD cells, are stable adhesive stromal cells isolat...

journal_title：Toxicologic pathology

authors： Ramot Y,Meiron M,Toren A,Steiner M,Nyska A

更新日期：2009-08-01 00:00:00

abstract：:Qualitative histopathology has been the gold standard for evaluation of morphological tissue changes in all organ systems, including the peripheral nervous system. However, the human eye is not sensitive enough to detect small changes in quantity or size. Peripheral nervous system toxicity can manifest as subtle chang...

journal_title：Toxicologic pathology

authors： Brown DL,Staup M,Swanson C

更新日期：2020-01-01 00:00:00

abstract：:Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in drug development. Despite over 20 years of pharmaceutical research, few ASOs have been marketed due to problems with clinical efficacy or preclinical toxicologic challenges. However, a number of recent developments have renewed i...

journal_title：Toxicologic pathology

authors： Frazier KS

更新日期：2015-01-01 00:00:00

abstract：:The development process of myelination varies between region and species. Fully myelinated fibers are required if mammalian neural circuits are to function normally. Histology samples at staggered time points throughout the study were examined at days 4, 5, 7, 8, 10, 14, 17, 24, 37, and 44. We suggest that the develop...

journal_title：Toxicologic pathology

authors： Downes N,Mullins P

更新日期：2014-07-01 00:00:00

abstract：:Recombinant soluble CD4 (sT4) has been shown to inhibit infectivity of HIV. Because of the role CD4 plays in the interaction of T-helper lymphocytes and cells bearing MHC Class II antigens, a potential adverse effect of therapy with sT4 is interference with lymphocyte function. To address this issue, we studied the ef...

journal_title：Toxicologic pathology

authors： Bugelski PJ,Thiem PA,Truneh A,Morgan DG

更新日期：1991-01-01 00:00:00

abstract：:This brief review summarizes our current understanding of vasculitis mediated by phlogistic immune complexes. The Arthus reaction and serum sickness both represent experimental models for immune complex disease. Immune complex phenomena occur in conjunction with C3 deficiency of dogs during canine distemper virus infe...

journal_title：Toxicologic pathology

authors： Krakowka S

更新日期：1989-01-01 00:00:00

abstract：:A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semi-transparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connecti...

journal_title：Toxicologic pathology

authors： Shibuya K,Tajima M,Yamate J

更新日期：1993-01-01 00:00:00

abstract：:Minipigs are now used in greater numbers in contract research organizations (CROs) as well as in the pharmaceutical industry. Most CROs or pharmaceutical companies use the Göttingen minipig, which displays a number of important background lesions. This review will discuss some of the more infrequent minipig background...

journal_title：Toxicologic pathology

authors： McInnes EF,McKeag S

更新日期：2016-04-01 00:00:00

abstract：:Morphologic lesions have received only limited attention as in vitro endpoints of toxicity. In the present work, "tissue" and cell morphology of control and toxicant-treated primary dissociated cerebrocortical cell cultures from fetal mice were examined using phase-contrast and bright-field microscopy. In untreated co...

journal_title：Toxicologic pathology

authors： Bolon B,Dorman DC,Bonnefoi MS,Randall HW,Morgan KT

更新日期：1993-09-01 00:00:00

abstract：:Many goitrogenic xenobiotics that increase the incidence of thyroid tumors in rodents exert a direct effect on the thyroid gland to disrupt one of several possible steps in the biosynthesis, secretion, and metabolism of thyroid hormones. This includes (a) inhibition of the iodine trapping mechanism, (b) blockage of or...

journal_title：Toxicologic pathology

authors： Capen CC

更新日期：1997-01-01 00:00:00

abstract：:Minoxidil, a long-acting vasodilating antihypertensive agent, reduces arterial blood pressure by a direct action on arteriolar smooth muscle. The present studies examined the gross anatomic, histologic and ultrastructural myocardial alterations produced by 2 daily doses of minoxidil in beagle dogs (0.5, 1, or 3 mg/kg)...

journal_title：Toxicologic pathology

authors： Herman EH,Ferrans VJ,Young RS,Balazs T

更新日期：1989-01-01 00:00:00

abstract：:Highly standardized and controlled inhalation studies are required for hazard identification to make test results reproducible and comparable and to fulfill general regulatory requirements for the registration of new drugs, pesticides, or chemicals. Despite significant efforts, the results of inhalation studies have t...

journal_title：Toxicologic pathology

authors： Pauluhn J,Mohr U

更新日期：2000-09-01 00:00:00

abstract：:Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...

journal_title：Toxicologic pathology

authors： Gregg NJ,Courtauld EA,Bach PH

更新日期：1990-01-01 00:00:00

abstract：:Oxymetholone has been identified as a suspected nongenotoxic carcinogen and has recently completed testing in a conventional National Toxicology Program (NTP) 2-yr rodent bioassay program. As a synthetic androgen with a limited historical database in toxicology, oxymetholone is an ideal candidate for prospective exami...

journal_title：Toxicologic pathology

authors： Stoll RE,Holden HE,Barthel CH,Blanchard KT

更新日期：1999-09-01 00:00:00

abstract：:Most available data on the involvement of p53 in rodent carcinogenesis are based on results of the end point of chemically or virally induced carcinogenesis, i.e., tumors. To investigate the role of altered p53 expression in early stages of rodent hepatocarcinogenesis in a systematic way, we treated male Wistar rats f...

journal_title：Toxicologic pathology

authors： Wirnitzer U,Töpfer R,Rosenbruch M

更新日期：1998-09-01 00:00:00

abstract：:The cochlea is one of the more common targets for toxic effects, yet current toxicologic screening in animals does not routinely evaluate the cochlea as a potential target organ. Although histopathologic sections are routinely taken from the eye and the optic nerve and tract and most studies include at least 1 section...

journal_title：Toxicologic pathology

authors： Mattsson JL

更新日期：2000-01-01 00:00:00

abstract：:ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymethyl)phenoxy]ethyl)-N-(beta-hydroxyphenethyl)ammonium chloride], are beta 3-adrenoceptor stimulants with selectivity for brown adipose tissue. ZD7144 is the hydrochloride salt of the S-en...

journal_title：Toxicologic pathology

authors： Waghe M,Westwood R,Nunn G,Kalinowski A,Aldridge A

更新日期：1999-03-01 00:00:00

abstract：:Expression of antigens in cells and tissues can be readily studied immunohistochemically with the use of antibodies. A panel of antibodies to cell-specific markers can be used to diagnose lesions, including tumors, in the hematopoietic and lymphoid systems. This review discusses the use of readily available antibodies...

journal_title：Toxicologic pathology

authors： Rehg JE,Bush D,Ward JM

更新日期：2012-01-01 00:00:00

abstract：:A comparative study of histochemical detection of eosinophils in fixed murine tissue is lacking. Five histochemical methods previously reported for eosinophil detection were quantitatively and qualitatively compared in an established murine RSV vaccine-enhanced inflammation model. Nonspecific neutrophil staining was e...

journal_title：Toxicologic pathology

authors： Meyerholz DK,Griffin MA,Castilow EM,Varga SM

更新日期：2009-02-01 00:00:00

abstract：:In the context of human hematopathology, the terms myelodysplasia and Myelodysplastic Syndromes (MDS) are applied to disorders of hematopoiesis that are clonal, neoplastic, and, in most forms, manifested as ineffective hematopoiesis with characteristic morphologic abnormalities in multiple cell lines. Studies of human...

journal_title：Toxicologic pathology

authors： Blue JT

更新日期：2003-01-01 00:00:00

abstract：:Toxicology of the male reproductive system has received increased interest in recent years partly fuelled by the growing reports of falling sperm counts and rising reproductive disorders in the human population. Recently revised regulatory guidelines for the safety assessment of pharmaceuticals and chemicals on reprod...

journal_title：Toxicologic pathology

authors： Creasy DM

更新日期：1997-03-01 00:00:00

abstract：:Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern i...

journal_title：Toxicologic pathology

authors： Goodglick LA,Vaslet CA,Messier NJ,Kane AB

更新日期：1997-11-01 00:00:00

abstract：:Monocrotaline pyrrole (MCTP) is a highly reactive pneumotoxic metabolite of the pyrrolizidine alkaloid plant toxin monocrotaline. When administered to rats, it causes a delayed and progressive lung injury, vascular remodeling, and pulmonary hypertension. Structural remodeling consists of endothelial cell swelling foll...

journal_title：Toxicologic pathology

authors： Lappin PB,Roth RA

更新日期：1997-07-01 00:00:00

abstract：:We examined the effects of the quinolone antibacterial agents pefloxacin (PFLX) and ofloxacin (OFLX) on the Achilles tendon of Sprague-Dawley rats. A single oral administration of PFLX 300 and 900 mg/kg or OFLX 900 mg/kg induced edema with mononuclear cell infiltration mainly in the inner sheath of the inner Achilles ...

journal_title：Toxicologic pathology

authors： Kato M,Takada S,Kashida Y,Nomura M

更新日期：1995-05-01 00:00:00

abstract：:In the present study, beta-catenin localization in hepatocellular neoplasms and hepatoblastomas, induced by oral administration of p-Nitroanisole (pNA) in Crj:BDF1 for 2 years, was evaluated by immunohistochemistry along with genetic alterations in exon 2 of beta-catenin by the polymerase chain reaction-single strand ...

journal_title：Toxicologic pathology

authors： Kushida M,Aiso S,Morimura K,Wei M,Wanibuchi H,Nagano K,Fukushima S

更新日期：2006-01-01 00:00:00

abstract：:The renal toxicity of harman and norharman, administered for 2 or 4 weeks at dietary levels of 1,000, 500, or 0 parts per million (ppm), was investigated in 6-week-old male F344/DuCrj rats. Although rats fed 1,000 ppm harman or norharman, but not the 500 ppm level, demonstrated marked body weight retardation from 1 we...

journal_title：Toxicologic pathology

authors： Hagiwara A,Asakawa E,Kurata Y,Sano M,Hirose M,Ito N

更新日期：1992-01-01 00:00:00

abstract：:Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cancer bioassays has been due to lack of historical data and diagnostic cr...

journal_title：Toxicologic pathology

authors： Nambiar PR,Turnquist SE,Morton D

更新日期：2012-06-01 00:00:00

abstract：:Partial hepatectomy (PH) and neonatal rat short-term liver focus models were used to examine the effects of selected chemicals that had been previously tested in the National Toxicology Program (NTP) 2-yr carcinogenicity studies. C.I. Solvent Yellow 14, monuron, chlorendic acid, and 4-hydroxyacetanilide were tested fo...

journal_title：Toxicologic pathology

authors： Maronpot RR,Pitot HC,Peraino C

更新日期：1989-01-01 00:00:00

abstract：:Many common inflammatory disorders are characterized by the infiltration of neutrophils across epithelial lined (mucosal) surfaces resulting in disruption of critical barrier function that protects from microbes and noxious agents. In such conditions, disease symptoms are complex but directly related to leukocyte effe...

journal_title：Toxicologic pathology

authors： Matthews JD,Weight CM,Parkos CA

更新日期：2014-01-01 00:00:00

abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...

journal_title：Toxicologic pathology

authors： Hottendorf GH

更新日期：1985-01-01 00:00:00