Abstract：
:The clinical, laboratory, and pathologic features of a syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, the expression of which can be precipitated in predisposed dogs by experimental treatment, and thus, its occurrence could complicate interpretation of toxicity studies. We have observed the disorder in 14 beagle dogs. The syndrome is rare and most cases for study were supplied by the breeder. Typical clinical signs observed included evidence of pain when the mouth was opened, grunting when lifted, and standing with an arched back and lowered head. Appetite was usually reduced. Body temperature was elevated (e.g., 104-106 degrees F). There was progressive, bilateral atrophy of temporal and cervical musculature. Such signs have been observed to persist unremittingly or, more commonly, with periods of expression and remission. Neutrophilic leukocytosis and thrombocytosis were present. Hemoglobin and hematocrit were usually slightly decreased. Serum total protein was usually normal but albumin was reduced and alpha-2 globulins were markedly increased. Rheumatoid factor was elevated in several dogs. Arteritis was observed histologically and was characterized by necrosis, intimal proliferation, neutrophil and mononuclear cell infiltration in the media and periarterial tissues, and hemorrhage. Amyloidosis was observed in several dogs. The cause of this disorder is unknown. Knowledge of the distinct features of this syndrome should obviate complication of interpretation of results in toxicity studies and hopefully will lead to studies of this syndrome to provide an understanding of its etiopathogenesis.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Hayes TJ,Roberts GK,Halliwell WHdoi
10.1177/019262338901700109subject
Has Abstractpub_date
1989-01-01 00:00:00pages
129-37issue
1 Pt 2eissn
0192-6233issn
1533-1601journal_volume
17pub_type
杂志文章abstract：:A retrospective analysis of microscopic evaluation data from control (device and/or saline-treated) animals in intrathecal studies in monkeys, dogs, sheep, and rats was conducted. The studies were performed by multiple testing facilities. All slide preparation and microscopic evaluation were conducted in the laborator...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310391679
更新日期：2011-01-01 00:00:00
abstract：:There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) techniques and of ocular relevant immunohistochemistry (IHC) or in situ hybrid...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315615553
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abstract：:Cytoplasmic vacuolation of sensory neurons has been reported to occur within the dorsal root ganglia in studies investigating various neuropathic conditions including the effects of neurotoxic chemicals. In this study, we investigated this lesion in adult (98-119 days old) male Long-Evans rats, after multiple exposure...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310369343
更新日期：2010-06-01 00:00:00
abstract：:Weber, K. (2017). Differences in Types and Incidence of Neoplasms in Wistar Han and Sprague-Dawley Rats. J Toxicol Pathol45, 64-75. (Original DOI: 10.1177/0192623316672075) In the January 2017 issue of Toxicologic Pathology, a number of in text Table citations were incorrectly labeled. The following are the sentences ...
journal_title：Toxicologic pathology
pub_type： 杂志文章,已发布勘误
doi：10.1177/0192623317702643
更新日期：2017-04-01 00:00:00
abstract：:To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles journal_title：Toxicologic pathology pub_type： 杂志文章 doi：10.1177/0192623309332994 更新日期：2009-04-01 00:00:00
abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339001800307
更新日期：1990-01-01 00:00:00
abstract：:To clarify the cell of origin of granular cell tumors in the rat brain, light and/or electron microscopic examinations were performed on 40 cases of spontaneous meningeal tumors in Wistar (Jcl: Wistar) rats. The meningeal tumors were histologically subclassified into 3 types: meningothelial meningiomas (MMs), 3 cases;...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339702500211
更新日期：1997-03-01 00:00:00
abstract：:Enzyme histochemistry was assessed in semi-thin glycolmethacrylate sections after 100 mg/kg 2-bromoethanamine (BEA) hydrobromide had been given ip to male Wistar rats to induce renal papillary necrosis. Changes in the proximal tubular marker enzymes alkaline phosphatase (Alk Phos), gamma-glutamytranspeptidase (GGT) an...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339001800106
更新日期：1990-01-01 00:00:00
abstract：:Systemic hypoxemia, occurring in space-occupying lung pathologies such as inflammation and neoplasms. reduces the gas exchange area and stimulates catecholamine secretion from the adrenal medulla where chronic endocrine hyperactivity may lead to hyperplasia and neoplasia. We investigated the possible correlation betwe...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262302753559605
更新日期：2002-03-01 00:00:00
abstract：:Histopathology is a widely used approach to evaluate effects of endocrine-active chemicals in the thyroid. However, effects at an ultrastructural level have hardly been examined in fish thyroids. In the present study, zebrafish was exposed to sublethal concentrations of propylthiouracil (PTU; 0-50 mg/L) and perchlorat...
journal_title：Toxicologic pathology
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
abstract：:Oxidant generation catalyzed by metals has been postulated to account for a lung injury following exposure to air pollution particles. In particles that are predominantly carbonaceous, it is difficult to implicate such an oxidative stress as the responsible mechanism, since concentrations of metals can be extremely lo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262330002800416
更新日期：2000-07-01 00:00:00
abstract：:One of the major roles for the toxicologic pathologists now and into the future will be to determine the biologic significance of chemically induced biochemical and molecular alterations detected in whole tissue homogenates or cell cultures. The biologically significant effects will then require further analysis to de...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1080/019262301301418973
更新日期：2001-01-01 00:00:00
abstract：:Mer proto-oncogene tyrosine kinase (MerTK), which is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). To investigate the effects of drug-induced MerTK inhibition on the retina, UNC569, a specific MerTK inhibitor, was orally administered to male mice ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623317749469
更新日期：2018-02-01 00:00:00
abstract：:Changes in the mRNA and protein expression of renin-secreting cells in the juxtaglomerular apparatus (JGA) were examined in the rat following administration of ZENECA ZD8731, an angiotensin II receptor antagonist. Doses of 0 or 90 mg/kg were administered daily by gavage for 26 wk. JGA hypertrophy was apparent in histo...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339502300303
更新日期：1995-05-01 00:00:00
abstract：:Over the past decade, laser capture microdissection (LCM) has grown as a tool for gene expression profiling of small numbers of cells from tumor samples and of specific cell populations in complex tissues. LCM can be used to study toxicant effects on selected cell populations within the testis at different stages of s...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623314526319
更新日期：2014-12-01 00:00:00
abstract：:A number of factors related to study design have the potential to impact clinical pathology test results during the conduct of nonclinical safety studies. A thorough understanding of these factors is paramount in drawing accurate conclusions from clinical pathology data generated during such studies, particularly when...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623316677066
更新日期：2017-02-01 00:00:00
abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623309351722
更新日期：2009-12-01 00:00:00
abstract：:The 2019 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology's 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This ar...
journal_title：Toxicologic pathology
pub_type：
doi：10.1177/0192623319876929
更新日期：2019-12-01 00:00:00
abstract：:Studies of xenobiotic biotransformation by in vitro techniques are destined to play an increasingly important role in assessing the safety and efficacy of drugs and other new chemical entities. The first part of this article summarizes some of the in vitro techniques that have been developed to evaluate xenobiotics as...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Age-related changes in gross and microscopic structure of the nasal cavity may alter local tissue susceptibility as well as the dose of inhaled toxicant delivered to susceptible sites. This article describes a novel method for the use of magnetic resonance imaging, 3-dimensional airway modeling, and morphometric techn...
journal_title：Toxicologic pathology
pub_type： 杂志文章,多中心研究
doi：10.1080/01926230601072343
更新日期：2007-01-01 00:00:00
abstract：:Recent advances in immunocytochemical techniques allow the localization of specific antigens in tissue sections. The work reported here attempts to evaluate the application of antibody-labeled, disease-related protein, followed by microscopy and computerized image analysis. Using an experimental anti-tumor, polyclonal...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338701500308
更新日期：1987-01-01 00:00:00
abstract：:This article provides a synopsis of the first two presentations from the second scientific session of the 37th Annual Symposium of the Society of Toxicologic Pathology in Indianapolis, Indiana, on June 18, 2018; the session focused on acute kidney injury. The first presentation, given by Dr. Kevin McDorman, focused on...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1177/0192623318798758
更新日期：2018-12-01 00:00:00
abstract：:The use of minipigs in preclinical safety testing of pharmaceuticals is considered an alternative to the more traditional dog and nonhuman primate (NHP) nonrodent species. Substantial evidence exists to suggest that the anatomy, physiology, and biochemistry of minipigs are similar enough to humans to consider them as ...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623315617562
更新日期：2016-04-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists are used in the treatment of type 2 diabetes mellitus and hyperlipidemias. In carcinogenicity studies, some of these agonists induced hemangiomas/hemangiosarcomas in mice, but not in rats. We hypothesized that increased endothe...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623311422080
更新日期：2011-12-01 00:00:00
abstract：:Duplications of the gastrointestinal tract are exceedingly rare in laboratory animals. We report a case of a communicating intestinal duplication in a 17-wk-old Sprague-Dawley (SD) rat. The duplication was present in the mesenteric border of the ileum, and both proximal and distal ends were communicated with the lumen...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600216
更新日期：1998-03-01 00:00:00
abstract：:Renal tubular hyaline droplets developed in male and female F344 rats bearing a rat fibrosarcoma-derived transplantable tumor (SS). The droplets accumulated exclusively in the proximal renal tubular epithelia as eosinophilic granules of various sizes in hematoxylin and eosin-stained sections. The granules stained brig...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262339802600517
更新日期：1998-09-01 00:00:00
abstract：:Existing liver perfusion models are largely limited by high degrees of ischemic and reperfusion injury and the lack of standardization. To establish a highly standardized perfusion model and minimize reperfusion injury, a porcine liver perfusion model was developed using an artificial heart pump (Buecherl Artificial H...
journal_title：Toxicologic pathology
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
abstract：:Hypopigmentation was the principal manifestation of systemic toxicity when the experimental platelet aggregation inhibitor, PD-89454, was orally administered to Beagle dogs for 28 days. Pigmentation changes were present in skin of nose, lips and eyelids and mucosa of hard palate. Fontana-Masson stain demonstrated decr...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/019262338901700310
更新日期：1989-01-01 00:00:00
abstract：:7,12-Dimethylbenz[a]anthracene (DMBA) presents a pollutant implicated in various toxicological effects. The aim of this experiment was to study the effects of DMBA administration on oxidative stress, histopathological signs, and 18 kDa translocator protein (TSPO) binding characteristics in rat liver. We also studied t...
journal_title：Toxicologic pathology
pub_type： 杂志文章
doi：10.1177/0192623310379137
更新日期：2010-10-01 00:00:00
abstract：:Ribonucleic acid (RNA) interference (RNAi) is a recently discovered phenomenon whereby the introduction of double stranded (ds) RNA into the cytoplasm of the cell results in the specific and efficient degradation of complementary messenger (m) RNA and, therefore, reduced protein production. It was discovered by chance...
journal_title：Toxicologic pathology
pub_type： 杂志文章,评审
doi：10.1080/01926230701197107
更新日期：2007-04-01 00:00:00
