Effects of chronic exposure to air pollution from Sao Paulo city on coronary of Swiss mice, from birth to adulthood.

abstract：:Mouse renal cell tumors (RCTs) were induced in male CBA mice by 5 subcutaneous injections of 8 mg 1,2-dimethylhydrazine (DMH)/kg body weight once a week. After a lag period of 2 yr kidneys were removed, and serial cryostat sections of the kidneys were histochemically analyzed for the following parameters: glycogen con...

journal_title：Toxicologic pathology

authors： Ahn YS,Chemeris GY,Turusov VS,Bannasch P

更新日期：1994-07-01 00:00:00

abstract：:The new Appendix A of the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, which gives guidelines for accommodation and care of animals and was approved on June 15, 2006, was the main reason the authors decided to investigate the origins of the regulatio...

journal_title：Toxicologic pathology

authors： Atalić B,Fatović-Ferencić S

更新日期：2009-10-01 00:00:00

abstract：:A number of factors related to study design have the potential to impact clinical pathology test results during the conduct of nonclinical safety studies. A thorough understanding of these factors is paramount in drawing accurate conclusions from clinical pathology data generated during such studies, particularly when...

journal_title：Toxicologic pathology

authors： Aulbach A,Provencher A,Tripathi N

更新日期：2017-02-01 00:00:00

abstract：:Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmation...

journal_title：Toxicologic pathology

authors： Hottendorf GH

更新日期：1985-01-01 00:00:00

abstract：:Sialodacryoadenitis (SDA) is a commonly-encountered coronaviral infection in laboratory rats that causes acute destruction of submandibular salivary glands. SDA results in depletion of salivary epidermal growth factor (EGF) and may thereby affect EGF-dependent cell growth processes. The purpose of this study was to de...

journal_title：Toxicologic pathology

authors： Kemp DR,Percy DH,Hayes MA

更新日期：1991-01-01 00:00:00

abstract：:Nephrotoxicity is one of the more common causes of attrition in nonclinical drug development. Like most tissues, the kidney has a limited number of ways of responding to toxicological insults from diverse mechanistic pathways, which can limit the ability to determine mechanisms of renal injury using the assays routine...

journal_title：Toxicologic pathology

authors： Ennulat D,Ringenberg M,Frazier KS

更新日期：2018-08-01 00:00:00

abstract：:A comparative study of histochemical detection of eosinophils in fixed murine tissue is lacking. Five histochemical methods previously reported for eosinophil detection were quantitatively and qualitatively compared in an established murine RSV vaccine-enhanced inflammation model. Nonspecific neutrophil staining was e...

journal_title：Toxicologic pathology

authors： Meyerholz DK,Griffin MA,Castilow EM,Varga SM

更新日期：2009-02-01 00:00:00

abstract：:Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to be spontaneous and ...

journal_title：Toxicologic pathology

authors： Treumann S,Buesen R,Gröters S,Eichler JO,van Ravenzwaay B

更新日期：2015-08-01 00:00:00

abstract：:Laser scanning cytometry (LSC) is a powerful tool for qualitative and quantitative analysis of tissue sections in preclinical drug development. LSC combines the strengths of flow cytometry with tissue architecture retention. This technology has been used predominantly with immunofluorescent techniques on cell culture ...

journal_title：Toxicologic pathology

authors： Peterson RA,Krull DL,Butler L

更新日期：2008-01-01 00:00:00

abstract：:Results of early nonclinical "General Toxicology" studies are used to set a safe starting dose for first-in-human (FIH) clinical trials. In FIH trials, the research subjects are typically healthy volunteers who have little to gain but much to lose if a trial goes wrong. With that in mind, good laboratory practice regu...

journal_title：Toxicologic pathology

authors： Seaton M

更新日期：2014-01-01 00:00:00

abstract：:BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1, has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, and histologic lesions of i...

journal_title：Toxicologic pathology

authors： Fletcher AM,Bregman CL,Woicke J,Salcedo TW,Zidell RH,Janke HE,Fang H,Janusz WJ,Schulze GE,Mense MG

更新日期：2010-02-01 00:00:00

abstract：:The distribution of 3,4,3',4'-tetrachlorobiphenyl (TCB), its effects on serum and hepatic retinoid, content and liver morphology were investigated in adult female WAG/Rij rats. Animals received a single intraperitoneal injection of either a corn oil vehicle, 15 or 200 mg TCB/kg body weight and were killed at 1, 3, 7, ...

journal_title：Toxicologic pathology

authors： Durham SK,Brouwer A

更新日期：1989-01-01 00:00:00

abstract：:A nondopaminergic antipsychotic agent, 5-ethyl-1,3,8-trimethyl-1H-imidazo]1,2-c]pyrazolo[3,4-e]pyrimidine (TIPP; PD 112488), has been tested for potential toxicity in rats. As part of a preclinical safety evaluation, 10 Wistar rats per sex were administered TIPP as a dietary admixture, receiving doses of 0, 5, 10, 20,...

journal_title：Toxicologic pathology

authors： Macallum GE,Albassam MA

更新日期：1994-01-01 00:00:00

abstract：:In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for...

journal_title：Toxicologic pathology

authors： Ozaki M,Ozaki K,Watanabe T,Uwagawa S,Okuno Y,Shirai T

更新日期：2005-01-01 00:00:00

abstract：:The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolati...

journal_title：Toxicologic pathology

authors： Irizarry AR,Gropp KE,Dixon D

更新日期：2017-01-01 00:00:00

abstract：:The toxicities of 2'-fluorouridine (2'-FU) and 2'-fluorocytidine-HCl (2'-FC) were separately evaluated in 2 species, male Fischer 344 (F334) rats and woodchucks. Particular attention was focused on the ability of these nucleosides to induce toxicities similar to those induced by the antiviral drug fialuridine (FIAU). ...

journal_title：Toxicologic pathology

authors： Richardson FC,Tennant BC,Meyer DJ,Richardson KA,Mann PC,McGinty GR,Wolf JL,Zack PM,Bendele RA

更新日期：1999-11-01 00:00:00

abstract：:Single doses of aspirin induce scattered foci of necrosis of proximal tubules in some strains of rats, whereas acute or sub-acute administration of phenylbutazone causes renal papillary necrosis. Initially, using Sprague-Dawley rats of CFY and CD strains, it became clear that these rats were not as susceptible to thes...

journal_title：Toxicologic pathology

authors： Owen RA,Heywood R

更新日期：1986-01-01 00:00:00

abstract：:The lung is a target organ for the toxic effects of several chemical agents, including natural products, industrial chemicals, pesticides, environmental agents, and occasionally, drugs. Factors that establish the lung as a target organ include selective tissue exposure, high tissue oxygenation, and the presence of bio...

journal_title：Toxicologic pathology

authors： Smith BR,Brian WR

更新日期：1991-01-01 00:00:00

abstract：:Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With goldenseal root powder, the primary finding was an increase in liver tumors in rats and mice, and with milk thistle extract, a decrease in spontaneous backgroun...

journal_title：Toxicologic pathology

authors： Dunnick JK,Singh B,Nyska A,Peckham J,Kissling GE,Sanders JM

更新日期：2011-02-01 00:00:00

abstract：:Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubulog...

journal_title：Toxicologic pathology

authors： Wang J,Zhong J,Yang HC,Fogo AB

更新日期：2018-12-01 00:00:00

abstract：:Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis. Here we describe the pathogenesis of premalignant disease in A/JCr mice infected with H. hepaticus. We inocula...

journal_title：Toxicologic pathology

authors： Rogers AB,Boutin SR,Whary MT,Sundina N,Ge Z,Cormier K,Fox JG

更新日期：2004-11-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak that started in Wuhan, China, in 2019 resulted in a pandemic not seen for a century, and there is an urgent need to develop safe and efficacious vaccines. The scientific community has made tremendous efforts to understand the disease, and unpara...

journal_title：Toxicologic pathology

authors： Bennet BM,Wolf J,Laureano R,Sellers RS

更新日期：2020-10-01 00:00:00

abstract：:Sections of thymus from New Zealand white rabbits used as controls in 28-day and 91-day percutaneous toxicity studies conducted at different laboratories were morphometrically assessed. Measurements of total thymic area, medullary area, and cortical area were greater for 28-day vs 91-day studies conducted at a given l...

journal_title：Toxicologic pathology

authors： Maurer JK,Gibbons BA,Bruce RD

更新日期：1990-01-01 00:00:00

abstract：:Substantial progress in understanding nongenotoxic or secondary mechanisms of tumorigenesis has been made over the past decade. However, the methods used in regulated studies for assessment of carcinogenic potential in chemicals in development have not evolved significantly. Based on the experience of over 30 yr of te...

journal_title：Toxicologic pathology

authors： Alden CL,Smith PF,Piper CE,Brej L

更新日期：1996-11-01 00:00:00

abstract：:Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control m...

journal_title：Toxicologic pathology

authors： Butler WH

更新日期：1996-07-01 00:00:00

abstract：:Normal retina and its cell layers are essential for processing visual stimuli, and loss of its integrity has been documented in many disease processes. The numbers and the axonal processes of retinal ganglion cells are reduced substantially in glaucoma, leading to vision loss and blindness. Similarly, selective loss o...

journal_title：Toxicologic pathology

authors： Muthuswamy A,Chen H,Hu Y,Turner OC,Aina OH

更新日期：2020-12-31 00:00:00

abstract：:To characterize the promoting activity of thiobenzamide (TB), a thiono-sulfur-containing xenobiotic, rats of both sexes were treated with the compound for 4 or 8 weeks after an initiating dose of diethyl-nitrosamine. The number, area (volume), and phenotypic complexity of the enzyme-altered hepatocyte foci were studie...

journal_title：Toxicologic pathology

authors： Malvaldi G,Chieli E,Saviozzi M

更新日期：1986-01-01 00:00:00

abstract：:Colorectal cancer, responsible for 50,000 deaths per year, is a contributing factor for considerable mortalities in the United States. Consumption of well-done red meat and saturated fats rich in polycyclic aromatic hydrocarbons may be one of the causative factors for sporadic colon cancer. The objective of this study...

journal_title：Toxicologic pathology

authors： Harris DL,Washington MK,Hood DB,Roberts LJ 2nd,Ramesh A

更新日期：2009-12-01 00:00:00

abstract：:The Syrian hamster embryo (SHE) cell-transformation assay represents a short-term in vitro assay capable of predicting rodent carcinogenicity of chemicals with a high degree of concordance (LeBoeuf et al [1996]. Mutat Res 356: 85-127). The SHE assay models the earliest identifiable stage in carcinogenicity, morphologi...

journal_title：Toxicologic pathology

authors： Mauthe RJ,Gibson DP,Bunch RT,Custer L

更新日期：2001-01-01 00:00:00

abstract：:Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we...

journal_title：Toxicologic pathology

authors： Calvisi DF,Thorgeirsson SS

更新日期：2005-01-01 00:00:00