Abstract:
:Tubular injury sensitizes glomeruli to injury. We review potential mechanisms of this tubuloglomerular cross talk. In the same nephron, tubular injury can cause stenosis of the glomerulotubular junction and finally result in atubular glomeruli. Tubular injury also affects glomerular filtration function through tubuloglomerular feedback. Progenitor cells, that is, parietal epithelial cells and renin positive cells, can be involved in repair of injured glomeruli and also may be modulated by tubular injury. Loss of nephrons induces additional workload and stress on remaining nephrons. Hypoxia and activation of the renin-angiotensin-aldosterone system induced by tubular injury also modulate tubuloglomerular cross talk. Therefore, effective therapies in chronic kidney disease may need to aim to interrupt this deleterious tubuloglomerular cross talk.
journal_name
Toxicol Patholjournal_title
Toxicologic pathologyauthors
Wang J,Zhong J,Yang HC,Fogo ABdoi
10.1177/0192623318796784subject
Has Abstractpub_date
2018-12-01 00:00:00pages
944-948issue
8eissn
0192-6233issn
1533-1601journal_volume
46pub_type
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